Protein Alignment Pi4KIIIalpha and Pik3c3

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_852079.2
• Gene: Pik3c3 / 225326
• MGIID: 2445019
• Length: 887
• Species: Mus musculus
• Alignment Length: 607
• Identity: 154/607 - (25%)
• Similarity: 250/607 - (41%)
• Gaps: 153/607 - (25%)

  Fly  1644 KYL-CTTKNLLQESPDLVYIL-SWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPY 1706
            |:| |...:|.||:...:.:| .|.|:....:|...|..| ::|...:|||..|.....|.:|.|
Mouse   332 KFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHY-TNPTVRRYAVARLRQADDEDLLMY 395

  Fly  1707 IPQLVQALRH---------------DTMGYVVEFIKN---------------------------- 1728
            :.||||||::               |:.....|.:.|
Mouse   396 LLQLVQALKYENFDDIKNGLEPTKKDSQTSASESLSNSGVSSGDIDSSQIITNPLPPVASPPPAS 460

  Fly  1729 -------------------ISR--RSQIVAHQLIWNMQTNMYM-----DEDQQHKDPNLYE---- 1763
                               |||  ::..:|:.|.|      |:     |:|.|.:||..:|
Mouse   461 KAKEVSDGENLEQDLCTFLISRACKNSTLANYLYW------YVIVECEDQDTQQRDPKTHEMYLN 519

  Fly  1764 ALDQLSQS---------IIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLA--- 1816
            .:.:.||:         ::.|...|.:.|.:|.......:...||..:   |..||..|.|.
Mouse   520 VMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRK---KKNERLQALLGDNE 581

  Fly  1817 --ALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSN 1879
              .||.:::   ..||..|:..:..|...:.|..:||. .|....|:
Mouse   582 KMNLSDVEL---IPLPLEPQVKIRGIIPETATLFKSAL-MPAQLFFK------------------ 624

  Fly  1880 NPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPG 1944
               :::..|..:        |||.|||:|||.|.||:|::...:.::..|||.|.||:|:||:..
Mouse   625 ---TEDGGKYPV--------IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTK 678

  Fly  1945 CG---VIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARA--NFVKSMAAYSLIGYL 2004
            .|   .|:.||.|:..|     |:..:..:|:.....|:.....:|..  .:|||.|.|.:|.|:
Mouse   679 HGFMQFIQSVPVAEVLD-----TEGSIQNFFRKYAPSETGPYGISAEVMDTYVKSCAGYCVITYI 738

  Fly  2005 LQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFC 2069
            |.:.|||..|:::.|.|.:.|||||::....|.   ...|.|||..|||..||| ..|..::.|.
Mouse   739 LGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPK---PLPPPMKLNKEMVEGMGG-TQSEQYQEFR 799

  Fly  2070 ELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFR---GQTINLLKQRFVATKNNKEAAAHMLAVIR 2131
            :.|..|||.:|.|.:.|::|.|||:|..:|...   .:|:..::.:|....:::||..:|.::|.
Mouse   800 KQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLID 864

  Fly  2132 NSYQNFRTRTYDMI----QYYQ 2149
            .|.........:.|    ||::
Mouse   865 ESVHALFAAVVEQIHKFAQYWR 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	44/214 (21%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	94/326 (29%)
Pik3c3	NP_852079.2	C2_PI3K_class_III	26..186	CDD:176042
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	149..170
		PI3Ka_III	283..503	CDD:238442	36/177 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..466		3/50 (6%)
		PI3Kc_III	539..883	CDD:270628	108/388 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810