DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and Pi4ka

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_001360884.1	Gene:	Pi4ka / 224020	MGIID:	2448506	Length:	2105	Species:	Mus musculus

Alignment Length:	2219	Identity:	993/2219 - (44%)
Similarity:	1360/2219 - (61%)	Gaps:	222/2219 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEG 75
            |..|||.|||.||..:|...:|||.|...||.: ..|:|.||.|.:||||||||:.:|...||:.
Mouse    34 YFNTVLSLARSLAVQRPASLEKVQKLLCMCPVD-FHGIFQLDERRRDAVIALGIFLIESDLQHKD 97

  Fly    76 QIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQV 140
            .:|||||||.:.|||..|::::.:.| .|..:|.||.|||||.|||||:|.:.|..|:||:...:
Mouse    98 CVVPYLLRLLRGLPKVYWVEESTARK-GRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEAIL 161

  Fly   141 ETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIFP---PELLPI 202
            :.|..|..:.::.......    .|||..:|.|.|::||.|||::::..||.::||   |..|.|
Mouse   162 QVLHVLLGMCQALEIQEKE----YLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVSPHSLRI 222

  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSM------------SGSLAQAQNA 255
            .:           ...|....||:.         ||.|:|.::            :.|::.....
Mouse   223 PE-----------ELEGVRRRSFND---------FRSILPSNLLTVCQEGTLKRKTSSVSSISQV 267

  Fly   256 SYDDGRQRCAGGKPSKP--SLHSYFSVPYDP------RTHFFTRYGSSFNQFPNMRVCESPTKGG 312
            |.:.|..     .||.|  |...||.....|      ..::|:...|||:        .||...|
Mouse   268 SPERGIP-----PPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFS--------ISPLFNG 319

  Fly   313 PRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVT 377
              ..|:....|::.|:.:..:.||::.:..|:.||...:.:...:......|.:||:.|.|.:..
Mouse   320 --ITYKEFCIPLEMLRELLNLVKKIVEEPVLKSLDAIVAGVMEANPSADLYYTTFSDPLYLTMFK 382

  Fly   378 LLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMAN 442
            :||:.|.:..||||.|.|::.:||...|...|.|||....|.:|...|      ::..|:...||
Mouse   383 MLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSE------MSPLKLRCQAN 441

  Fly   443 AACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMDHMPLLM 507
            ||||||:|||::||                    :.|:.||.:||:||..:.|.|:::.|:|||:
Mouse   442 AACVDLMVWAVKDE--------------------QGAENLCIKLSEKLQSKTSSKVIIAHLPLLI 486

  Fly   508 VCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQ--SLAQQKKEKELTPFKIAV- 569
            .||:|||:|..:||.:..:....||||||.|||:|.||:.:..|  ::|.       :..||:|
Mouse   487 CCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAG-------SDIKISVT 544

  Fly   570 -QHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANV 633
             :||:| |..|:.|...:|          :.:|.|||.||:|:...|:|..|:|...|.|.:|::
Mouse   545 NEHSES-TLNVLPGKKNQP----------SMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASL 598

  Fly   634 SNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQN 698
            ||||:.:::|..:       ::|:..:.|..|||:||||:||.|..:.|||...|:||:.||..:
Mouse   599 SNRLYISQESDKD-------AHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLD 656

  Fly   699 ALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQ-FHHVSDAVVNALGNIA 762
            .||:|||||::|:. ..:::.|:..:|.:::|:::|:.|::..:::.. :.|.|.||:|||.|||
Mouse   657 VLIIDQLGCLVITG-NQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIA 720

  Fly   763 ANIQGDAEMLELLGKLLELFVQIGLDG----ERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRL 823
            ||||.:..:.|||..|||||||:||:|    ||:.:..| |.||||.|||||:||||||||.|||
Mouse   721 ANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGP-ALKASSSAGNLGVLIPVIAVLTRRL 784

  Fly   824 PPIKNPRQRLHKLFKDFWAYCVVMGFT--NARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRE- 885
            ||||..:.||.|||:|||.|.|:|||.  .:.|||.:||:||.:||.|||||...:  |..:|.
Mouse   785 PPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPS--KEPLRSV 847

  Fly   886 LNYTLAIKSDSV-----NELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENAD 945
            |.|..|:|:|:|     :||||.|:.||:...: |:..||||.||..|||||||.||.:||..:.
Mouse   848 LQYNSAMKNDTVTPAELSELRSTIINLLDPPPE-VSALINKLDFAMSTYLLSVYRLEYMRVLRST 911

  Fly   946 EPSLEPIM-SYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVL--YAHDEIREKVLESQATLLLV 1007
            :|....:| .|..|.|:|:||:|:.|||..|||:||:.|.|::  .|..:..|:.||..|..|||
Mouse   912 DPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLV 976

  Fly  1008 YFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTP 1072
            .||||||.|:.|||:|||.|||:||||||:..||..||||||.|:.|||.|.:::.|...:...|
Mouse   977 NFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAP 1041

  Fly  1073 YTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPV--LAHHSGLALA 1135
            |.:.:.|:..|||..:||||.||..|:.|||||||..|:||||||.|:....|  |:.|:|||:|
Mouse  1042 YRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMA 1106

  Fly  1136 FDSVV---SSSAQHT----GTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLL------SVLSE 1187
            .:|::   ..:.|:|    ..:::||:||..|...|::.|.||::||||:.|::      ..:|:
Mouse  1107 TESILHFAGYNKQNTTLGATQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSD 1171

  Fly  1188 KDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAME 1252
            .:|     .:|.|:..|........:..|:::.||.||...:...:|||.:....|.:|.|..||
Mouse  1172 LNK-----MMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGME 1231

  Fly  1253 TAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIA 1317
            ||:.||:|:|..:..:|:.|::||..||..|.|::.|||:.||:...||||.|..:....|..:.
Mouse  1232 TALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSVETKEADPLAASEASQPRPCPPEVT 1296

  Fly  1318 PHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVL---KSSKQNRQVSTVGCRFKLLQCGLS 1379
            ||.||:..|.:..:.||||:.|:||:|..||.|.:.:.   .....||.|:.:|.|||||..|||
Mouse  1297 PHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGARGSMNRHVAAIGPRFKLLTLGLS 1361

  Fly  1380 LLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVT 1444
            ||..:.:|.:..||:|||:|||.|.|||..||..|.|..::|.|||.|::|||..|.|:||:|..
Mouse  1362 LLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTA 1426

  Fly  1445 SEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGG---S 1506
            |::...|                              |..|||          .:.:..|.   :
Mouse  1427 SQLVPPD------------------------------NQDTRS----------NLDITVGSRQQA 1451

  Fly  1507 SSGWYNTIPHST--STLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSL 1569
            :.||.||.|.|:  ||:||:|..||:.. :.....|.|||:|.|:|.|||.|:|.|||||||.|.
Mouse  1452 TQGWINTYPLSSGMSTISKKSGMSKKTN-RGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSA 1515

  Fly  1570 PDLIV--PGEEQITEWRNR--PYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVC 1630
            |:|.:  .||..:..||::  ......|:|...|||..:|.|||.||.|.||.|.|..||:|||.
Mouse  1516 PELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVR 1580

  Fly  1631 SDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTL 1695
            .||.||..:|||:|:|.|...:..::|:|.::|.|:|..|...|:|||..||.|||||||.||.|
Mouse  1581 LDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVL 1645

  Fly  1696 SSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPN 1760
            .|:|.:::|.||||:|||||:|.||||.|:|...:.:||::|||.||||:||:|:||:...|||:
Mouse  1646 RSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPD 1710

  Fly  1761 LYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQG 1825
            :.:.|:||.:.|..|.||.||.||:||||||.|||.||..|:.:.||.|||.|||:|||.:|||.
Mouse  1711 IGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQP 1775

  Fly  1826 GCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPN----SQE- 1885
            ||||||||||:||||||.|||||||||||||||:|:|.|||::|||...::..::..    |||
Mouse  1776 GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDAEDECFSQEA 1840

  Fly  1886 DAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIEC 1950
            |.|..    .|||||||||||.||||||||:|.:||||||.||||||:|||||||||||||||||
Mouse  1841 DGKKI----CWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIEC 1901

  Fly  1951 VPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNI 2015
            :|:..||||||||||.|:.:||..||||||:..||.||.||::|||||||:.:||||||||||||
Mouse  1902 IPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNI 1966

  Fly  2016 MIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVR 2080
            |:||.|||||||||||||||||||:|:|||:||||||||||||||::..||||.|:||:.:||||
Mouse  1967 MLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 2031

  Fly  2081 PYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMI 2145
            ||.||:||||:|||||||||||||||.|||.||......:|||..::.||:|.:.:.|:||||||
Mouse  2032 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQNCFLSNRSRTYDMI 2096

  Fly  2146 QYYQNQIPY 2154
            |||||.|||
Mouse  2097 QYYQNDIPY 2105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	90/174 (52%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	225/321 (70%)
Pi4ka	NP_001360884.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PI4Ka	1550..1725	CDD:238443	90/174 (52%)
		PI4Kc_III_alpha	1786..2104	CDD:270711	225/321 (70%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833635
Domainoid	1	1.000	986	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11171
Inparanoid	1	1.050	1695	1.000	Inparanoid score	I77
Isobase	1	0.950	-	0	Normalized mean entropy	S2354
OMA	1	1.010	-	-		QHG60094
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	1	1.000	-	-		FOG0002854
OrthoInspector	1	1.000	-	-		oto93771
orthoMCL	1	0.900	-	-		OOG6_101741
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4430
SonicParanoid	1	1.000	-	-		X2686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750