DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and Prkdc

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_035289.2	Gene:	Prkdc / 19090	MGIID:	104779	Length:	4128	Species:	Mus musculus

Alignment Length:	2358	Identity:	444/2358 - (18%)
Similarity:	752/2358 - (31%)	Gaps:	871/2358 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   293 GSSFNQFP--NMRVCESPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIF- 354
            |..||:.|  |:.:.|:..     .|.|...|||:       |...:..|.....:.::|.|..
Mouse  1961 GFLFNEKPEKNLFIFENLI-----DLKRCYTFPIE-------VEVPMERKKKYIEIRKEARDAAN 2013

  Fly   355 ----SLHQIKGYCY---KSFSETLNLVLVTLLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTEL 412
                |.|.:....|   .|.||.::             |.|    |:..||.:    ..:.|...
Mouse  2014 GASGSPHYMSSLSYLTDSSLSEEMS-------------QFD----FSTGVQSY----SYSSQDRK 2057

  Fly   413 QNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAIRDETVDV------DYNVP-SLQNG 470
            ......|.||.::......:.:.:::.:....|:..::..|:....:|      :.::| .|...
Mouse  2058 PTTGHFQRREHQDSMTQDDIMELEMDELNQHECMAPMIALIKHMQRNVIAPKGEEGSIPKDLPPW 2122

  Fly   471 LQFLLKKEADKLCGRLSQKLNLEL-SHKIVMD----------H--MPLLM--VCLEGLGKLAHKF 520
            ::||    .||| |..|..||:.| ..|:|::          |  .|||.  ||......:.:..
Mouse  2123 MKFL----HDKL-GNASVSLNIRLFLAKLVINTEEVFRPYAKHWLSPLLQLAVCENNREGIHYMM 2182

  Fly   521 PNIAGTSISYL---------RDFLVAPSPILGKLHDHA--------------MQSLAQQKKEKEL 562
            ..|..|.:|:.         :|.::| :.:|..|..|.              :::|.:..||...
Mouse  2183 VEIVATILSWTGLATPTGVPKDEVLA-NRLLRFLMKHVFHPKRAVFRHNLEIIKTLVECWKECLS 2246

  Fly   563 TPFKIAVQHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTL---DQF 624
            .|:::..:..           :.|.|.|.....|           |:.|.|.:  |:.|   |..
Mouse  2247 IPYRLIFEKF-----------SHKDPNSKDNSVG-----------IQLLGIVI--ANNLPPYDPN 2287

  Fly   625 C-------VPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNI 682
            |       ..|||.|:|   |...|....:..|             :||              .|
Mouse  2288 CDITSAMYFEALVNNMS---FVKYKEVYAAAAE-------------VLG--------------LI 2322

  Fly   683 LQFFIQRFCKVPSEQNALIVDQLGC-MIISQCETH---VFDEIMKMFSRVTVQSASLAYTSDPEH 743
            ||:..:|         ..::.:|.| ::|.|.:.|   :.|:.:...:::.
Mouse  2323 LQYITER---------KHVIAELVCELVIKQLKQHQNTMEDKFIVCLNKIA-------------- 2364

  Fly   744 RKQFHHVSDAVVNALGNIAANIQGDAEML----------ELLGKLLEL----FVQI--GLDGERS 792
             |.|..::|..:|||..:.....|..:.|          |:.|..|:|    |:|:  ..|.||
Mouse  2365 -KGFPPLADRFLNALFFLLPKFHGVMKTLCLEVVLCRAEEITGLYLQLKSKDFLQVMRHRDDER- 2427

  Fly   793 YDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIK-----NP------------RQRLHKLFKDF 840
                   ||         :.:.::..:|.:|.||:     ||            |::::
Mouse  2428 -------QK---------VCLDIVYKMVAKLKPIELRELLNPVVEFVSHPSPTCREQMY------ 2470

  Fly   841 WAYCVVMGFTNARLWPADWY--------QGVQQI--AAKSPL---LISQT-----------AHKS 881
                      |..:|..|.|        :..|:|  .||..|   ||.:.           :|::
Mouse  2471 ----------NILMWIHDNYRDQESQNDEDSQEIFKLAKDVLIQGLIDENVGLQLIIRNFWSHET 2525

  Fly   882 DM--RELNYTLAIKS-----DSVN--ELRSQILVLLEHSSDNVATAINKLSFAQC---TYLLSVY 934
            .:  ..|:..||:.|     ..|:  .|.:..|:.:...|.:....|.:...::|   .|.:...
Mouse  2526 RLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTRMSPDYLNPIFEHPLSECEFQEYTIDPD 2590

  Fly   935 W------LEMLRVENADEPSLEPIMSYLCDTALQRDKTG-----------------------IW- 969
            |      |..:.:|....||:....:.....:.||.|.|                       .|
Mouse  2591 WRFRSTVLTPMFIETQASPSILHTQTQEGPLSDQRQKPGQVRATQQQYDFTPTQASVERSSFDWL 2655

  Fly   970 --QCVKCVADQ-VFEK---FRNVLYAH---------------------------DEIREKV---L 998
              ..:..:||. ||..   ..::|::|                           ||:..:|   .
Mouse  2656 TGSSIDLLADHTVFSSETLSSSLLFSHKRTEKSQRMSCKSVGPDFGTKKLGLPDDEVDNQVKSGT 2720

  Fly   999 ESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFP-HLLWNRRVL------------WCMLDILQL 1050
            .|||.:|.:               ...||.||.. .||:.:|.|            :.|....|:
Mouse  2721 PSQADILRL---------------RRRFLKDREKLSLLYAKRGLMEQKLEKDIKSEFKMKQDAQV 2770

  Fly  1051 LAYSLSLDPNEETPTLRV----VSTPYTLQLM---DSLPARELRLKDFADRCQGIVNEAMKWAPR 1108
            :.|...  .:.:.|.:::    :.||  ||.:   |.:.|::|    |:....||:.|..|:...
Mouse  2771 VLYRSY--RHGDLPDIQIQHSGLITP--LQAVAQKDPIIAKQL----FSSLFSGILKEMNKFKTT 2827

  Fly  1109 S-----TRSHLQEYPNQIPTPVL--------------AHHSGLALAFDSV---VSSSAQHTG--- 1148
            |     |::.||::...:.|..|              .|...|.|...||   ..:|.|..|
Mouse  2828 SEKNIITQNLLQDFNRFLNTTFLFFPPFVSCIQEISCQHPDFLTLDPASVRVGCLASLQQPGGIR 2892

  Fly  1149 --------TMSKRP--------SCVNSDTPRFVSVLCL-RS--KY---AGEISGLLSVLSEKDKA 1191
                    .|.|.|        :|:..|..|::.:..| ||  :|   .|..|..|....:...|
Mouse  2893 LLEEALLRLMPKEPPTKRVRGKTCLPPDVLRWMELAKLYRSIGEYDVLRGIFSSELGTTQDTQNA 2957

  Fly  1192 GLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAVE 1256
            .||:.. ||..:|..                            |:..|.::||.......|...|
Mouse  2958 LLAEAR-SDYCQAAK----------------------------LYDEALNKLEWVDGEPTEAEKE 2993

  Fly  1257 CWQWV-------LTARQDLELCFIQEMVS--------AWQTTF--------------------EK 1286
            .|:..       |:..::||.|....:||        .|...|                    |.
Mouse  2994 FWELASLDCYNNLSKWKELEYCSTVNIVSENSLDLSKMWSEPFYQETYLPYVIRSKLKLLLQGEG 3058

  Fly  1287 RMGLFAWETEVTHPLAAYEGCKLVSKPIL---IAPHLIWLQLLSEMVDTAKYCNRDKVEMFC--- 1345
            ...|..:..|..:        |.:.|.:|   .:..|..|.:|.:.:|.|.|..::.:::|.
Mouse  3059 NQSLLTFVDEAMN--------KELQKTVLELQYSQELSLLYILQDDIDRATYYIKNGIQIFMQNY 3115

  Fly  1346 ----LLLHRC-LPVLKSSK-------------QNRQVSTVGCRFKLLQCGLS------------- 1379
                :||:|. |..|:|.:             ::..:|::|...:||:...|
Mouse  3116 SSIDVLLYRSRLAKLQSVQTLAEIEEFLSFICKHGDLSSLGPLRRLLKTWTSRYPDVVTDPMHIW 3180

  Fly  1380 -------------LLQGNTIPK---SLS-----RNILRERIYSNALDYFCGPPTCPNQSREQLLE 1423
                         :.:..|.|.   |:|     .:|.|| :|....|..|...:|....:.:::|
Mouse  3181 DDIITNRCFFLSKIEERLTAPSGDHSMSVDEDEESIDRE-VYEPKEDVRCMLQSCRFTMKMKMIE 3244

  Fly  1424 ------DIMILLKFWQTMRSEKKHLVTSEV------GDYDLTNASVSSTQ--MLAVRNNPETASL 1474
                  :..:.:|..:.|..|.|   |.|:      ..|...|...|.||  ...|.|..:|.:|
Mouse  3245 SAWKQSNFSLSMKLLKEMHKESK---TREIWRVQWLHSYSQLNHCRSHTQSPREQVLNMLKTITL 3306

  Fly  1475 ISGGGLVNDYTRSMSAS-GNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSY 1538
            :....:.|...:::.|| ..::.:|             .|.......||:.......|:
Mouse  3307 LDESDISNYLNKNIQASCDQSILLG-------------TTCRIMADALSREPACLSDLE------ 3352

  Fly  1539 DKDYMKKRNLILELL---AVELEFLITWYNPNSLPDL--IVPGEEQITEWRNRPYKSTVWRDYAR 1598
                ..|.|.||.|.   |...|.:||.....:...|  .|...|:.|:.....:::...|.:|.
Mouse  3353 ----ENKVNSILTLSGSNAENTETVITGLYQRAFHHLSKAVQSAEEETQLSCWGHEAAAERAHAY 3413

  Fly  1599 LAWCYNPALAVFLPQRIKNAE-----------------IIDEEVSRLVCSDPIAVCHIPEAL--- 1643
            :      .|..|..|:::..|                 ::::.:..|..:...|....|..|
Mouse  3414 M------TLVGFCDQQLRKVEESASQKTSAEMEAYPALVVEKMLRALKLNSSEARLKFPRLLQII 3472

  Fly  1644 -KYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQY----PSHPLTAQYAVKTLS-SYPAES 1702
             :|...|.|::  :.::..|..|      |.:.:.|...    ....:..|:.|:.:: :||...
Mouse  3473 EQYSEETLNIM--TKEISSIPCW------QFIGWISHMMALLDKEEAIAVQHTVEEIADNYPQAI 3529

  Fly  1703 VLPY-IPQLVQALRHDTMGY----VVEFIKNISRRSQIVAHQLI---------------WNMQTN 1747
            :.|: |.....:.::.:.|:    .||.||:.....::: |..|               |...|
Mouse  3530 IYPFIISSESYSFKNTSSGHNNKAFVERIKSKLDHGEVI-HSFINALDQLSNPDLLFKDWVSDT- 3592

  Fly  1748 MYMDEDQQHKDP-----------NLYEALDQL----------------SQSIIASFSGAAKRFYE 1785
                :|:..|:|           .:|.||..|                .:..:.||.....:...
Mouse  3593 ----KDELGKNPVNKKNIEKLYERMYAALGDLRAPGLGPFRRRFIQAFGKEFVKSFGNGGSKLLT 3653

  Fly  1786 REFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQS 1850
            .:.|.|.|||.                   :.|.|:|...  .||.|.:      :||   |..|
Mouse  3654 MKVDDFCKITG-------------------SLLVRMKKDS--KLPGNLK------EYS---PWMS 3688

  Fly  1851 AAKAPYLARFRVYRCGITELETRAM-EVSNNP---------NSQEDAKMTLGV------------ 1893
            ..||.:|.         .|||.... :..:.|         ...|..|:.|.:
Mouse  3689 EFKAQFLK---------NELEIPGQYDGKSKPLPEYHVRISGFDERVKVMLSLRKPKRIVIRGHD 3744

  Fly  1894 ESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGL----DLFLFPYRVVATAPGCGVIECV--- 1951
            |.....:.|.|:|:|||....|:..:...|..|...    ::.|..||||......|:||.:
Mouse  3745 EKEYPFLVKGGEDLRQDQRIEQIFEVMNAILSQDAACSQRNMQLRTYRVVPMTSRLGLIEWIENT 3809

  Fly  1952 ----------------------PNAKSRD------QLGRQTDSG--------------------- 1967
                                  |.|..||      ::..::|:|
Mouse  3810 MTLKDLLLSNMSQEEKVANNSDPKAPIRDYKDWLMKVSGKSDAGAYVLMYSRANRTETVVAFRRR 3874

  Fly  1968 --------LSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKD-GHI 2023
                    |...|...  ..|.:.|.|.|::|..|.|...:..:||.|.|||..|.|:..: |.:
Mouse  3875 ESQVPPDLLKRAFVKM--STSPEAFLALRSHFASSHALLCISHWLLGIGDRHLNNFMVAMETGSV 3937

  Fly  2024 IHIDFGFMFESSPGGNIGFEP-----DMKLTDEMVMIM-----GGKMDSPAFKWFCELCVQAFLA 2078
            |.||||..|    |....|.|     ..:||.:.|.:|     .|.|        |.:.|.|..|
Mouse  3938 IGIDFGHAF----GSATQFLPVPELMPFRLTRQFVSLMLPMKETGLM--------CTVMVHALRA 3990

  Fly  2079 VRPYQDAIVSLVSLMLDT 2096
            .|       |...|:.||
Mouse  3991 FR-------SCAGLLTDT 4001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	37/247 (15%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	80/358 (22%)
Prkdc	NP_035289.2	HEAT 1	288..323
		HEAT 2	1001..1037
		HEAT 3	1050..1086
		Interaction with C1D. /evidence=ECO:0000250	1501..1536
		Leucine-zipper	1501..1536
		TPR 1	1720..1753
		ArAE_1_C	<1766..1822	CDD:288564
		NUC194	1812..2198	CDD:285387	56/274 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2049..2071		4/25 (16%)
		KIP-binding. /evidence=ECO:0000250	2432..3213		153/856 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2614..2635		4/20 (20%)
		FAT	3024..3470	CDD:280429	83/486 (17%)
		PIKKc_DNA-PK	3719..4014	CDD:270716	69/304 (23%)
		FATC	4097..4128	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900