DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and Pik3cd

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	XP_006538704.1	Gene:	Pik3cd / 18707	MGIID:	1098211	Length:	1074	Species:	Mus musculus

Alignment Length:	1286	Identity:	253/1286 - (19%)
Similarity:	431/1286 - (33%)	Gaps:	431/1286 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly  1023 YLSFLVDRFPHLLWNRRVLW---------------------CM---------------------- 1044
            ||:|.|.|..:|...::|||                     |:
Mouse    31 YLNFPVSRNANLSTIKQVLWHRAQYEPLFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPF 95

  Fly  1045 LDILQLLAYSLSLDPNEETPTLRVVSTPYTLQL------MDSLPARELRLKDFADRCQGIVNEA- 1102
            |.:|:|:|       .|.....:::::..:|.:      .|||  |:..:.||..:.:....||
Mouse    96 LPVLRLVA-------REGDRVKKLINSQISLLIGKGLHEFDSL--RDPEVNDFRTKMRQFCEEAA 151

  Fly  1103 --------MKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNS 1159
                    ::|...|       :|.|:........:||.               .:|.|...||
Mouse   152 AHRQQLGWVEWLQYS-------FPLQLEPSARGWRAGLL---------------RVSNRALLVN- 193

  Fly  1160 DTPRFVSVLCLRSKYAGEISGLLSVLSEKD------------KAGLADRLVSDVWEACAEKSDAR 1212
                        .|:.|........:|.||            ||.:..:.:.:..|..|.:.:.|
Mouse   194 ------------VKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEEYALQVNGR 246

  Fly  1213 HRGALWRATAYL----------IICSEISRKLLHAVASSQLELFTESAM---------------- 1251
            |.        ||          .|||     .||:..:..|.:...|::
Mouse   247 HE--------YLYGNYPLCHFQYICS-----CLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQK 298

  Fly  1252 ------------ETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRM------GLFAWETEVT 1298
                        .::|..|        .||..|..|::...:...::||      |||.....:
Mouse   299 PRAKPPPIPAKKPSSVSLW--------SLEQPFSIELIEGRKVNADERMKLVVQAGLFHGNEML- 354

  Fly  1299 HPLAAYEGCKLV-SKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNR 1362
                    ||.| |..:.:....:|.|.|...:..   |:..::...|..|:..:...|.::..:
Mouse   355 --------CKTVSSSEVNVCSEPVWKQRLEFDISV---CDLPRMARLCFALYAVVEKAKKARSTK 408

  Fly  1363 QVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNAL--DYFCGPPTCPNQSREQLLEDI 1425
            :.|      |...|.::                    ::|.:  ||           ::||....
Mouse   409 KKS------KKADCPIA--------------------WANLMLFDY-----------KDQLKTGE 436

  Fly  1426 MILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPET---ASLISGGGLVNDYTRS 1487
            ..|. .|.::..||..|: :..|               .||.||.|   |:|:.....|..:...
Mouse   437 RCLY-MWPSVPDEKGELL-NPAG---------------TVRGNPNTESAAALVIYLPEVAPHPVY 484

  Fly  1488 MSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYM-KKRNLILE 1551
            ..|....:.:|.....|..:         ....|..|....:|...:...::||.: |.|:.:.|
Mouse   485 FPALEKILELGRHGERGRIT---------EEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQE 540

  Fly  1552 LLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRD-----YARLAWCYNPALAVFL 1611
                        :.|.:|..|::     :|:|......:.|.|:     ..|..|.
Mouse   541 ------------HFPEALARLLL-----VTKWNKHEDVAQVSREGGSGRQPRGRWT--------- 579

  Fly  1612 PQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYIL-SWSPVTPIQALA 1675
                                       :| |..|| ||| |.|    ::|:| ||..:..:.||.
Mouse   580 ---------------------------VP-AHPYL-TTK-LSQ----MLYLLCSWPELPVLSALE 610

  Fly  1676 YFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGY----VVEFIKNISRRSQIV 1736
            .....:|. .....:|:|:|.....:.:..|:.||||.|::::  |    :.:|:...:..::.:
Mouse   611 LLDFSFPD-CYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYES--YLDCELTKFLLGRALANRKI 672

  Fly  1737 AHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEI 1801
            .|.|.|::::.|::                   .|:...| |.....|.|......|:....||.
Mouse   673 GHFLFWHLRSEMHV-------------------PSVALRF-GLIMEAYCRGSTHHMKVLMKQGEA 717

  Fly  1802 RSFAKGIE-----------------------RKNACLAALSRIKVQGGCYLPSNPEAMVLDI-DY 1842
            .|..|.:.                       |:...:.|||.::      .|.:|..::.:: ..
Mouse   718 LSKLKALNDFVKVSSQKTTKPQTKEMMHMCMRQETYMEALSHLQ------SPLDPSTLLEEVCSV 776

  Fly  1843 SSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDV 1907
            ...|.|.|..|..::    :|                   |.|:|    |.......|||.|||:
Mouse   777 EQCTFMDSKMKPLWI----MY-------------------SSEEA----GSAGNVGIIFKNGDDL 814

  Fly  1908 RQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAK--SRDQLGRQTDSGLSE 1970
            |||||.||:|.:...:::|.||||.:.||..:.|....|:||.|.::.  :..||.:...:..:.
Mouse   815 RQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAA 879

  Fly  1971 YFQHQY-----GDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGF 2030
            :.:...     .....:....|...|..|.|.|.:..|:|.|.|||:.||||.:.|.:.|||||.
Mouse   880 FNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGH 944

  Fly  2031 M---FESSPGGNIGFEPDMKLTDEMVMIMGGKM-DSPAFKWFCELCVQAFLAVRPYQDAIVSLVS 2091
            .   |::..|.|....|.:...|.:.:|..||. :|..|:.|...|.:|:..:|.:....:.|.:
Mouse   945 FLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFA 1009

  Fly  2092 LMLDTGLP---CFRGQTINLLKQRFVATKNNKEAAAHMLA----VIRNSYQ 2135
            ||...|||   |  .:.|..||......|..:||..|...    .:|.|::
Mouse  1010 LMRAAGLPELSC--SKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWK 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	33/179 (18%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	88/319 (28%)
Pik3cd	XP_006538704.1	PI3K_p85B	32..107	CDD:396665	14/81 (17%)
		PI3K_rbd	182..281	CDD:395642	24/139 (17%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	44/240 (18%)
		PI3Ka	504..713	CDD:214537	54/300 (18%)
		PI3Kc_IA_delta	705..1072	CDD:270718	99/389 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810