DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Pik3c2a

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_035213.2 Gene:Pik3c2a / 18704 MGIID:1203729 Length:1686 Species:Mus musculus


Alignment Length:1238 Identity:255/1238 - (20%)
Similarity:458/1238 - (36%) Gaps:357/1238 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1101 EAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALA------FDSVVSSSAQHT---GTMSKRPSC 1156
            :|:....||...||:...|           |.:|:      ..|::..:||.|   |.:|::...
Mouse   307 DAVLLEERSPSCHLERKVN-----------GKSLSGATVTRSQSLIIRTAQFTKAQGQVSQKDPN 360

  Fly  1157 VNSDTPRFVSVLCLRSKYAGEISGLL-SVLSEKDKAGLADR------LVSDVW---EACAEKSDA 1211
            ..|..|...|:|........|::... |::..|.|....|.      |:|.|.   ..|.|.:..
Mouse   361 GTSSLPTGSSLLQEFEVQNDEVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNMCGENASV 425

  Fly  1212 RHRGALWRATAYLIICSEISRKLLHAV----ASSQLELFTESAMETAVECW-----QWVLTARQD 1267
            :             :..||....|...    .||.:|:....|:     ||     ..|......
Mouse   426 K-------------VSIEIEGLQLPVTFTCDVSSTVEIIIMQAL-----CWVHDDLNQVDVGSYI 472

  Fly  1268 LELCFIQEMV--SAWQTTFEKRMGLFAWETEVTHPLAAYEG-CKLVSK-------PILIAPHLIW 1322
            |::|..:|::  :....:.|.......|:||:...|..... |:.:::       |:.:..:|..
Mouse   473 LKVCGQEEVLQNNHCLGSHEHIQNCRKWDTEIKLQLLTLSAMCQNLARTAEDDEAPVDLNKYLYQ 537

  Fly  1323 LQL----------LSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCG 1377
            ::.          :.|::|:..|    :||:          .|::..|:|.|..|   .|.::..
Mouse   538 IEKPYKEVMTRHPVEELLDSYHY----QVEL----------ALQTENQHRAVDQV---IKAVRKI 585

  Fly  1378 LSLLQGNTIP------KSLSR--NILRE------------------------------------- 1397
            .|.|.|...|      |.|.|  |:.|.                                     
Mouse   586 CSALDGVETPSVTEAVKKLKRAVNLPRNKSADVTSLSGSDTRKNSTKGSLNPENPVQVSMDHLTT 650

  Fly  1398 ------RIYSNALDYFCGPPTCPNQSR---------EQLLEDIMI---LLKFWQTMRSEKKHLVT 1444
                  |:::|:.....|   ||..||         |||...:..   :...| ....||.:|:.
Mouse   651 AIYDLLRLHANSSRCSTG---CPRGSRNIKEAWTATEQLQFTVYAAHGISSNW-VSNYEKYYLIC 711

  Fly  1445 S---------------EVGDYD----------------------------------LTNASVSST 1460
            |               :||.|.                                  |..:|.||.
Mouse   712 SLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPIQISQLPLESVLHLTLFGVLNQSSGSSP 776

  Fly  1461 QMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRS 1525
            .....|..||....:|  ..:.|:.|.::.....:.:.        :|...|:||   ..:.|:|
Mouse   777 DSNKQRKGPEALGKVS--LTLFDFKRFLTCGTKLLYLW--------TSSHTNSIP---GAIPKKS 828

  Fly  1526 NRSKRLQYQKD----SYDKDYMK---KRNLI----LELLAVELEFLITWYNPNSLPDLI------ 1573
            ...:|:..|.|    ::|..|..   .||:|    ||.|..:::        ..|.|:|      
Mouse   829 YVMERIVLQVDFPSPAFDIIYTSPQIDRNIIQQDKLETLESDIK--------GKLLDIIHRDSSF 885

  Fly  1574 -VPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVC 1637
             :..|:::..|.||.|             |            :|:...:    .:::.|.|    
Mouse   886 GLSKEDKVFLWENRYY-------------C------------LKHPNCL----PKILASAP---- 917

  Fly  1638 HIPEALKY--LCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPA 1700
                ..|:  |..|.:||.:         |.|:.|:.||.....::....:.: .||..:.:...
Mouse   918 ----NWKWANLAKTYSLLHQ---------WPPLCPLAALELLDAKFADQEVRS-LAVSWMEAISD 968

  Fly  1701 ESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYE 1763
            :.:...:||.||||:::..  ..:|.|:.:.:..:..:||.|.|.:       :|..| |.:...
Mouse   969 DELADLLPQFVQALKYEIYLNSSLVRFLLSRALGNIQIAHSLYWLL-------KDALH-DTHFGS 1025

  Fly  1764 ALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIK---VQG 1825
            ..:.:..::::......:....::......:..|:.::|. |.|..|:.....::.|::   ::.
Mouse  1026 RYEHVLGALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQ-ASGSTRQVVLQKSMERVQSFFLRN 1089

  Fly  1826 GCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMT 1890
            .|.||..|..:..:::..|.:...|.|                 :..:...|:.:|..:|...| 
Mouse  1090 KCRLPLKPSLVAKELNIKSCSFFSSNA-----------------MPLKVTMVNADPLGEEINVM- 1136

  Fly  1891 LGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAK 1955
                      ||||:|:||||||||:|.|...|:.:.||||.:..:|.::|....|::|.||.:.
Mouse  1137 ----------FKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASD 1191

  Fly  1956 SRDQL-------GRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNG 2013
            :..::       |...|..|:|:.: :| :.|.:|::.|..||:.|.|...:..|:|.|.||||.
Mouse  1192 TLRKIQVEYGVTGSFKDKPLAEWLR-KY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDRHND 1254

  Fly  2014 NIMIDKDGHIIHIDFG-FMFESSPGGNIGFEPD---MKLTDEMV-MIMGGKMDSPAFKWFCELCV 2073
            |||:...||:.||||| |:..:...|:  |:.|   ..||.:|. :|.||:..:..|:.|.:||.
Mouse  1255 NIMLRSTGHMFHIDFGKFLGHAQMFGS--FKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCC 1317

  Fly  2074 QAFLAVRPYQDAIVSLVSLMLDTGLPCFRG-QTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNF 2137
            ||:..:|...:..::|:|||:.:|||.... |.:..::........:.||......:|.:|..:.
Mouse  1318 QAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSI 1382

  Fly  2138 RTR 2140
            .|:
Mouse  1383 ATK 1385

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 31/178 (17%)
PI4Kc_III_alpha 1836..2153 CDD:270711 92/318 (29%)
Pik3c2aNP_035213.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000250|UniProtKB:O00443 2..142
ETS_PEA3_N <40..>210 CDD:368026
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 41..68
PI3K_rbd 421..513 CDD:366310 19/109 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 615..640 0/24 (0%)
C2A_PI3K_class_II 677..849 CDD:175979 31/185 (17%)
PI3Ka_II 869..1038 CDD:238441 39/231 (17%)
PI3Kc_C2_alpha 1043..1395 CDD:270720 102/376 (27%)
PX_PI3K_C2_alpha 1426..1534 CDD:132822
Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000269|PubMed:16338929 1488..1493
C2B_PI3K_class_II 1560..1681 CDD:176027
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O00443 1606..1617
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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