DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and piki-1

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_510529.1	Gene:	piki-1 / 181618	WormBaseID:	WBGene00009552	Length:	1607	Species:	Caenorhabditis elegans

Alignment Length:	917	Identity:	181/917 - (19%)
Similarity:	346/917 - (37%)	Gaps:	263/917 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1352 LPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQG-------NTIPKSLS----------RNILRERI 1399
            |.:..||::.:||..:.|:     |    |.|       |.:.|.|:          ||.....|
Worm   510 LKLSSSSQRVKQVIMLLCK-----C----LHGIVPEKLYNEMQKYLASTTEDQLVHHRNDFLREI 565

  Fly  1400 YSNALDYFCG--------PP----TCPNQSREQLLEDIMILL-------KFWQTMRSEKKHLVTS 1445
            :| .|:.:|.        ||    |.|.......::.:.|:|       :.||:..||
Worm   566 HS-FLELYCRCTVSRYNIPPLQIITKPKVEVLSKMDFLQIMLNSVHSIPEHWQSQYSE------- 622

  Fly  1446 EVGDYDLTNASVSSTQMLAVRNN--PETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSS 1508
                :.::......||:|...:|  |:|        :.||:
Worm   623 ----FYMSLDLYHGTQVLDGFSNKVPKT--------IKNDH------------------------ 651

  Fly  1509 GWYNTIPHSTSTLSKRSN-----RSKRL----------------QYQKD----------SYDKD- 1541
             ::..||.......||.|     |..|:                :|..|          .||::
Worm   652 -FFPRIPLDLYAKFKRLNLCQYPRETRIVVSISGTVRNSAQAANEYNPDIVMLGYCSVPLYDENL 715

  Fly  1542 YMKKRNLILELLAVELEFLITWYNPNSL------PDLIVPGEEQITEWRNRPY-------KSTVW 1593
            :|::..|.|.|..::.:.::..:.|...      |.||:    ....|....|       ...:.
Worm   716 FMRQGPLFLPLTLLKKQPMLKPFGPYPYIKDARDPILIM----SFKIWDTEIYFPNVVIDMQCIP 776

  Fly  1594 RDYARLAWCYNPALAVFLPQRIKNAE--IIDEEVSRLVCSDPIAVCHIPEALK------------ 1644
            :|:|.|    :.....:|.:.|:|.:  .::.:...|:....:.:.:.||||.
Worm   777 QDFATL----DIETQEYLLELIENQDTSTLETDDQDLIWQKRLHLTNQPEALPLVLSSLQDWSFG 837

  Fly  1645 YLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQ 1709
            ::.....:|:|         |:|:.|..|:.:...:||...:.| :||::|:....:.:...|||
Worm   838 FVMRVYQILEE---------WAPLRPEIAMEFLLPKYPDERIRA-HAVQSLARGSTDFLYHTIPQ 892

  Fly  1710 LVQALRHD--TMGYVVEFIKNISRRSQIVAHQLIWNMQ-----------------TNMYMDEDQQ 1755
            .::|||.:  ....:.:||..:|..|.....::.|.:|                 .|:......:
Worm   893 FIEALRFELYEKSALADFILELSFVSLDFTFEIYWQLQQRVDHCAVDDLPYAIRCQNLQQKMIDE 957

  Fly  1756 HKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFA--KGIERKNACLAAL 1818
            |::|||                   |...:.:.:...::.::..::||.:  ..|||       |
Worm   958 HENPNL-------------------KTDIKLQHELLNELDSIQDDLRSKSGDSEIER-------L 996

  Fly  1819 SRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARF-----RVYRCGITELETRAMEVS 1878
            .|::.:.|          :||     ...:|:..:.|....|     |:..|.:.....:.:::
Worm   997 HRLRTRLG----------ILD-----SKLLQNKVRLPICPAFDCTGVRIEECSVFNSNAKPLKI- 1045

  Fly  1879 NNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAP 1943
                      :..|:....:.|.|..||:|||...::::.....|::..||||.:..:|::....
Worm  1046 ----------VFRGLNMNYSIIHKRDDDMRQDAFVMKMLNEMDRIWKSNGLDLRMITFRIMPVGY 1100

  Fly  1944 GCGVIECVPNA-------KSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLI 2001
            ..|:.|.|.|.       |.....|...|..|.::......||.:  ::.|:.||::|.|.:.::
Worm  1101 RRGMGELVLNCATLMEIQKEEGLRGVLNDEILRKWLMKHNSDEFA--YKEAQENFIRSCAGWCIV 1163

  Fly  2002 GYLLQIKDRHNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFEPD---MKLTDEMV-MIMGGKMD 2061
            .|:|.|.||||.||:..|:||:.||||| :|.:.....  ||..|   ...|.||. :|..|:..
Worm  1164 TYVLGIGDRHNDNILFTKNGHVFHIDFGKYMGDWQMAA--GFRRDRVPFVFTTEMFHVINNGRAP 1226

  Fly  2062 SPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHM 2126
            :...:.|.:.|.:||..:|..::.:.:|:.:|..:.:|.....::..::...:...::.:|....
Worm  1227 TQYNQKFIDYCCKAFNHLRRNKNTLTNLLRIMACSDIPGINMDSLAFVENNLMLDLSDTDATVQF 1291

  Fly  2127 LAVIRNS 2133
            .|:|:||
Worm  1292 TAMIQNS 1298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	37/207 (18%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	75/315 (24%)
piki-1	NP_510529.1	PI3K_rbd	348..456	CDD:197540
		C2A_PI3K_class_II	593..775	CDD:175979	35/229 (15%)
		PI3Ka_II	784..948	CDD:238441	32/173 (18%)
		PI3Kc_II	964..1315	CDD:270710	84/372 (23%)
		PX_domain	1346..1454	CDD:295365
		C2B_PI3K_class_II	1473..1604	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810