Protein Alignment Pi4KIIIalpha and pifk-1

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_508177.2
• Gene: pifk-1 / 180443
• WormBaseID: WBGene00018076
• Length: 666
• Species: Caenorhabditis elegans
• Alignment Length: 667
• Identity: 163/667 - (24%)
• Similarity: 281/667 - (42%)
• Gaps: 173/667 - (25%)

  Fly  1616 KNAEIIDEEVS-----------RLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVT 1669
            |..||..|:.:           ||:.|:..   :.|.|::||    |.:|:.|.|.::
 Worm    42 KEIEIEKEDTTKPTHDRQSWTMRLISSESF---NAPMAVEYL----NSIQDKPSLTFL------- 92

  Fly  1670 PIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLV---------QALRHDTMGYVVE- 1724
                                  .|.|...|.:.:..|:|||:         .::.|   .|:.|
 Worm    93 ----------------------GKRLFDLPEKDLDFYLPQLMYLYVTKVDAASVSH---AYIEER 132

  Fly  1725 -----------------FIKNISRRSQIVAHQL-IWNMQTNMYMDEDQQHKDPNLYEALDQLSQ- 1770
                             |.||:..:.:  .|.| :.::.:...:....|..|..:..:||:|.:
 Worm   133 NKKDAQFTVLCIWLLNCFTKNVPNKYE--NHALMLKSLLSRSNVPGTSQSADNMITLSLDRLEET 195

  Fly  1771 -----SIIASFSGAAKR--------------FYER-------------EFDFFGKITAVSGEIRS 1803
                 |.....:||..|              .||:             :.:|.|::..:..::..
 Worm   196 NWTVGSSYGKSAGALARAAIQKESTLTAEHDSYEKSRCGPISTKLLTNQQNFIGRLVYIGVKLTE 260

  Fly  1804 ---FAKGIERKNACLAALSRIK--VQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVY 1863
               .:...|:..|..:.||.:.  :....::|.:.|..:.:|..:....:.|..|.||:....|.
 Worm   261 HHLLSSKQEKTIALQSELSMLNSMLPNSVWIPFDFENTMFNICVNESAVLNSKDKVPYVFFAEVI 325

  Fly  1864 RCG----------------ITELETRAMEVSNNP-NSQEDAKMTLGVESWQ-------------- 1897
            |..                |.:.::.::.:.|.. :...|..:.:..|||.
 Worm   326 RSSPNYNSNIKTLSSVEPRIKKSQSESVLLKNKSYHDSTDPSIAVFAESWAEKKARIRGSSRYEN 390

  Fly  1898 -------AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAK 1955
                   ..|.|.|||:.|:..|.|::..||:::.:.|:.|:|.||::|......|:||.|.:..
 Worm   391 HQKWDLIPVIVKTGDDLSQEAFAQQLLFTFKDLWHEEGVPLYLRPYKIVCIGSDAGLIEPVLDTL 455

  Fly  1956 SRDQL-----------GRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKD 2009
            |..|:           |..|...|..:|::.:|..:|:.:..|:.||::|.|||||:.|.||:||
 Worm   456 SLHQIKRHLTNVFRMNGNVTTPSLKHHFENVFGPVNSETYVNAQKNFIQSTAAYSLVSYYLQLKD 520

  Fly  2010 RHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFE-PDMKLTDEMVMIMGGKMDSPAFKWFCELCV 2073
            ||||||::|.|||:||||:||:..||| .|:||| ...|||.|::.:||| :||..|.:|..|.:
 Worm   521 RHNGNILLDMDGHLIHIDYGFLLSSSP-RNLGFETAPFKLTTEIIDVMGG-IDSDMFLYFKSLLL 583

  Fly  2074 QAFLAVRPYQDAIVSLVSLM-LDTGLPCFR--GQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQ 2135
            :..:|.|.:...||||..:| ..:.:.|||  .:|:..|:.||..:..:::....:..::..|..
 Worm   584 RGLMAARKHHRRIVSLAEIMSAGSKMQCFRAGAETVRALEARFHVSSTDEQLQQLVDTLVEGSRD 648

  Fly  2136 NFRTRTYDMIQYYQNQI 2152
            ::.||.||..|||.|.|
 Worm   649 SYTTRFYDSFQYYTNGI 665

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	36/203 (18%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	114/370 (31%)
pifk-1	NP_508177.2	PI4Kc_III_beta	367..666	CDD:270712	104/301 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820