Protein Alignment Pi4KIIIalpha and age-1

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_496462.2
• Gene: age-1 / 174762
• WormBaseID: WBGene00000090
• Length: 1182
• Species: Caenorhabditis elegans
• Alignment Length: 1379
• Identity: 273/1379 - (19%)
• Similarity: 483/1379 - (35%)
• Gaps: 431/1379 - (31%)

  Fly   984 RNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQY-------LSFLVDRFPHLLWNRRVL 1041
            |:::..|.....::.:       ::.|.:|..:|.:.:|:       |.....:...||.|..|
 Worm    21 RDLIAGHGRNSRRISQ-------MHVNILHPQLQTMVEQWQMRERPSLETENGKGSLLLENEGV- 77

  Fly  1042 WCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWA 1106
               .||:.:..:.            .|:|..:...|.:...:.|::|.||..:...:: ..|||.
 Worm    78 ---ADIITMCPFG------------EVISVVFPWFLANVRTSLEIKLSDFKHQLFELI-APMKWG 126

  Fly  1107 PRSTRSHLQEY---------------PNQIPTPVLAHHSGLALAF---------DSVVSSSAQHT 1147
            ..|.:.  |:|               .:..|...|..|....:.|         |..:.|...|.
 Worm   127 TYSVKP--QDYVFRQLNNFGEIEVIFNDDQPLSKLELHGTFPMLFLYQPDGINRDKELMSDISHC 189

  Fly  1148 --GTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGL--LSVLSEKDKAGLADRLVSDVWEACAEK 1208
              .::.|....::.:..:|.:.|..|:|......||  .|..:..::..|.      |.|:|.:.
 Worm   190 LGYSLDKLEESLDEELRQFRASLWARTKKTCLTRGLEGTSHYAFPEEQYLC------VGESCPKD 248

  Fly  1209 SDARHRGA------LWRATAYLI--IC------------SEISRKLLHAVASSQLELFTESAMET 1253
            .:::.:.|      .||.....|  :|            :|..:.|||.......:|......:.
 Worm   249 LESKVKAAKLSYQMFWRKRKAEINGVCEKMMKIQIEFNPNETPKSLLHTFLYEMRKLDVYDTDDP 313

  Fly  1254 AVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHP---LAAYEGCK------- 1308
            |.|.|             |:|   .|.:|||            ||:|   |.:|:|.:
 Worm   314 ADEGW-------------FLQ---LAGRTTF------------VTNPDVKLTSYDGVRSELESYR 350

  Fly  1309 ----------LVSKPI-----LIAPHLI-------WLQLLSEMVDTAKYCNRDKVEMFCLLLHRC 1351
                      ||.|..     |..||.:       .|.:||..:|:..
 Worm   351 CPGFVVRRQSLVLKDYCRPKPLYEPHYVRAHERKLALDVLSVSIDSTP----------------- 398

  Fly  1352 LPVLKSSKQNRQVSTVGCRFK----LLQCGLSLLQGNTIPKSLSRNILRERIYSNALDY------ 1406
                |.||.:..|.|   .|:    |.|..|         ..|..|::...:..:..|:
 Worm   399 ----KQSKNSDMVMT---DFRPTASLKQVSL---------WDLDANLMIRPVNISGFDFPADVDM 447

  Fly  1407 --------FCGPPTCPNQSREQLLEDIMILLKF--WQTMRSEKKHLVTSEVGDYDLTNASVSSTQ 1461
                    :.|..|..::|..:      :..:|  |      .|.:.|.::...|:..::|.|.:
 Worm   448 YVRIEFSVYVGTLTLASKSTTK------VNAQFAKW------NKEMYTFDLYMKDMPPSAVLSIR 500

  Fly  1462 ML--AVRNNPETASLISGGGLVN-------DYTRS------------------MSASGNAVGMGM 1499
            :|  .|:...|...:    |.||       |..|.                  :..:|..:|...
 Worm   501 VLYGKVKLKSEEFEV----GWVNMSLTDWRDELRQGQFLFHLWAPEPTANRSRIGENGARIGTNA 561

  Fly  1500 GVAGGGSSSGWYNTIPHS---TSTLSKRSNRSKRLQYQKDSY-----DKDYMKKRNLILELLAVE 1556
            .|....||.|....:|..   |..:..||..::.|....|.|     |..|.|     |::|..:
 Worm   562 AVTIEISSYGGRVRMPSQGQYTYLVKHRSTWTETLNIMGDDYESCIRDPGYKK-----LQMLVKK 621

  Fly  1557 LEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEII 1621
            .|           ..:::..:||...|        :||.|.:.   ..|.|.:.|.:
 Worm   622 HE-----------SGIVLEEDEQRHVW--------MWRRYIQK---QEPDLLIVLSE-------- 656

  Fly  1622 DEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYIL--SWSPVTPIQALAYFSRQYPSH 1684
                                 |.::.|.:....|    :|::  .|.|.:...||....::....
 Worm   657 ---------------------LAFVWTDRENFSE----LYVMLEKWKPPSVAAALTLLGKRCTDR 696

  Fly  1685 PLTAQYAVKTLSSYPAESVLP-----YIPQLVQALRHDTMGYVVEFIKNISRR--SQIVAHQLIW 1742
             :..::||:.|:    |.:.|     :|..|:|||:::........:..::|.  ...:.|:|.|
 Worm   697 -VIRKFAVEKLN----EQLSPVTFHLFILPLIQALKYEPRAQSEVGMMLLTRALCDYRIGHRLFW 756

  Fly  1743 NMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVS--------- 1798
            .::..:....|...|... |..:..|.::.:.......| ...|:.|...::|.:|
 Worm   757 LLRAEIARLRDCDLKSEE-YRRISLLMEAYLRGNEEHIK-IITRQVDMVDELTRISTLVKGMPKD 819

  Fly  1799 -------GEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPY 1856
                   .|:||.:..:|..::.|..:.::            ..|::|.....|     :||.|.
 Worm   820 VATMKLRDELRSISHKMENMDSPLDPVYKL------------GEMIIDKAIVLG-----SAKRPL 867

  Fly  1857 LARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFK 1921
            :..::                  |.|.:.|..:     .:.|.|||.|||:|||||.|||:.:..
 Worm   868 MLHWK------------------NKNPKSDLHL-----PFCAMIFKNGDDLRQDMLVLQVLEVMD 909

  Fly  1922 NIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKS--RDQLG--------RQTD-SGLSEYFQHQ 1975
            ||::...:|..|.||.|:......|:||.|||.|:  ..|:|        |..| |.::::.:.|
 Worm   910 NIWKAANIDCCLNPYAVLPMGEMIGIIEVVPNCKTIFEIQVGTGFMNTAVRSIDPSFMNKWIRKQ 974

  Fly  1976 YG--DESSKEFQAARAN---------------------FVKSMAAYSLIGYLLQIKDRHNGNIMI 2017
            .|  ||..|..:.:..|                     |:.|...||:..|::.|||||:.|:|:
 Worm   975 CGIEDEKKKSKKDSTKNPIEKKIDNTQAMKKYFESVDRFLYSCVGYSVATYIMGIKDRHSDNLML 1039

  Fly  2018 DKDGHIIHIDFGFMFESSPGGNIGFEPDMK---LTDE-MVMIMGGKM---DSPAFKWFCELCVQA 2075
            .:||...|||||.:..... ..:|.:.|.:   ||:. |.:|..||.   :|...:.|..|||:|
 Worm  1040 TEDGKYFHIDFGHILGHGK-TKLGIQRDRQPFILTEHFMTVIRSGKSVDGNSHELQKFKTLCVEA 1103

  Fly  2076 FLAVRPYQDAIVSLVSLMLDTGLP--CFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQ-NF 2137
            :..:...:|..|||.:|||...||  ..:....:|.|..|...::.:||......:...::. ::
 Worm  1104 YEVMWNNRDLFVSLFTLMLGMELPELSTKADLDHLKKTLFCNGESKEEARKFFAGIYEEAFNGSW 1168

  Fly  2138 RTRT---YDMIQYY 2148
            .|:|   :..:::|
 Worm  1169 STKTNWLFHAVKHY 1182

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	29/183 (16%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	99/360 (28%)
age-1	NP_496462.2	PI3K_p85B	98..177	CDD:197539	15/81 (19%)
		PI3K_rbd	241..360	CDD:197540	28/146 (19%)
		C2_PI3K_like	420..574	CDD:176026	28/178 (16%)
		PI3Ka	606..798	CDD:214537	42/258 (16%)
		PKc_like	793..1181	CDD:304357	108/429 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810