Protein Alignment Pi4KIIIalpha and fwd

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_061501565.1
• Gene: fwd / 1269716
• VectorBaseID: AGAMI1_000991
• Length: 1775
• Species: Anopheles gambiae
• Alignment Length: 969
• Identity: 232/969 - (23%)
• Similarity: 374/969 - (38%)
• Gaps: 311/969 - (32%)

  Fly  1303 AYEGCKLVSKP----ILIAPHLI--WLQL--LSEMVDT-AKYCNRDKVEMFCLLLHRCLPVLKSS 1358
            ::.|.|:.|.|    .|..|.||  ::|:  |||::|. ..|..|..|: |.|   :|:.:|::.
Mosquito   998 SFIGNKIFSFPHIEVDLYIPQLIVMYMQIEELSEVLDPYLVYRCRQSVD-FSL---KCVWLLEAY 1058

  Fly  1359 KQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLE 1423
            ..|.::.:..              ||:|.|.||  :||| :|             |.:.|.:|
Mosquito  1059 NFNTEMLSGA--------------GNSIRKHLS--LLRE-LY-------------PKRERVKL-- 1091

  Fly  1424 DIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSM 1488
                     ....:....::|:            :.:::||..|:|...:..:...:...:.||.
Mosquito  1092 ---------AAAAANNAPIITT------------TGSELLATGNDPTLQAHPALSAVRKTHHRSQ 1135

  Fly  1489 SASGNAVGMGMGVAG--------------GGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYD 1539
            |   :|.|| ||:..              .|...|..:..|.....||  :.|         ::|
Mosquito  1136 S---DATGM-MGLLAQHHHHHHALHAAPLPGGVPGPSSRTPVCLGDLS--TGR---------AFD 1185

  Fly  1540 KD---YMKKRNLILEL-------------LAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPY 1588
            ..   :...|..:.:|             ||.|.||:      .:|.|:    .:.:|..:.:..
Mosquito  1186 NGCVCFESVRGTVNDLLGQQTVCSCGAPKLAPEKEFM------KALIDI----GKMLTCLQTKIE 1240

  Fly  1589 KSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLL 1653
            |::..|....|.....|| .|:||               |....|..|..|.|....:..:|:
Mosquito  1241 KTSRLRILLNLINKNLPA-RVWLP---------------LHSETPHHVVRITEEKTAVLNSKD-- 1287

  Fly  1654 QESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRH-- 1716
             ::|.::|:    .|..:|.:      |.|                     |.||:::..|||
Mosquito  1288 -KTPYIIYV----EVVEVQDI------YTS---------------------PVIPKMMPTLRHTK 1320

  Fly  1717 ----------------DTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEAL 1765
                            |..|      .|.|:..|..|               .||..|.....|.
Mosquito  1321 SEERLDSSISASALNGDEAG------SNPSKTEQTTA---------------CQQTGDETAAAAA 1364

  Fly  1766 DQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLP 1830
            ..|..:..||.:.:..|.                                :.||...|..|....
Mosquito  1365 APLPAAAAASLAASRSRH--------------------------------SKLSECSVDNGGNGG 1397

  Fly  1831 SNPEAMV----------------LDIDYSSGTPMQSAAKAPYLARFRV--YRC---------GIT 1868
            :...:|:                :...|.|.|.|.|...|  :::|.|  |..         .|.
Mosquito  1398 NGGGSMMELGLTEDDVWSQEDDEITAQYLSLTKMSSDRDA--ISQFSVDSYDSRDHHTPALFNIG 1460

  Fly  1869 ELETR---------AMEVSNNPNSQEDAKM---------------TLG-VESWQ--AAIFKVGDD 1906
            |::.|         |...||:|:....|.:               ..| ::||:  :||.|.|||
Mosquito  1461 EVKKRHCANLNSENAKPFSNDPSDPSAAALKEPWHEKEKQIRNSSPYGHLQSWRLLSAIVKCGDD 1525

  Fly  1907 VRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEY 1971
            :||:::|.|::.:||.|:::..:.|::.|||:|..:...|:||.:.|..|..|:.:.::..|.:|
Mosquito  1526 LRQELMATQLLQMFKLIWEEEKVGLWVQPYRIVCLSNDSGLIETIVNTVSLHQIKKNSNKSLKDY 1590

  Fly  1972 FQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSP 2036
            |..::||..:..|:.|:.||:.|.|||.||.||||:||||||||::..|||:|||||||:...||
Mosquito  1591 FIDEFGDVETVAFRRAQRNFMHSCAAYCLISYLLQVKDRHNGNILLHSDGHLIHIDFGFILSISP 1655

  Fly  2037 GGNIGFEPD-MKLTDEMVMIMGGKMDSPAFKWFCE---LCVQAFLAVRPYQDAIVSLVSLMLDTG 2097
             .|:|||.. .|||.|.|.:|||    |..:.:||   |.:....|.|.:.|.|:::|.:|..:.
Mosquito  1656 -KNLGFEQSPFKLTPEFVDVMGG----PESELYCEFKYLLLDGLKAARKHMDRIINIVEIMRSSS 1715

  Fly  2098 -LPCFR---GQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQI 2152
             ||||:   ..|:..|:.||......:|....:..:|::|..:..|:.||..||..|.|
Mosquito  1716 QLPCFKNGCSGTVRNLRNRFHMNLTEQELERKVEQLIQDSLNSLSTKLYDGYQYITNGI 1774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	62/306 (20%)
		PI4Ka	1600..1775	CDD:238443	34/192 (18%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	124/379 (33%)
fwd	XP_061501565.1	None