DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Trrap

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:XP_006504844.1 Gene:Trrap / 100683 MGIID:2153272 Length:3911 Species:Mus musculus


Alignment Length:2574 Identity:449/2574 - (17%)
Similarity:796/2574 - (30%) Gaps:968/2574 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 PIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLN----LVLVTLLREL- 382
            |.|.|:.:  |.:.|....|.|||.....::.|:       ...|.||.|    |:.:.::.|| 
Mouse    85 PAQQLRKL--VLEILHRIPTNEHLRPHTKNVLSV-------MFRFLETENEENVLICLRIIIELH 140

  Fly   383 ----------LQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNK---------------QQDQERE 422
                      :.|.:|......|::.:.|.|.|.|.|...:|.               :.:.|||
Mouse   141 KQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQGIPENTVPPPEMVGMITTVAVKVNPERE 205

  Fly   423 RREENGIAVV--NKYKVNVMANAACVDLLVWAIRD--------ETVDVDYNVPSLQNGLQF---- 473
            ..|....:::  ....:.|:|....:.:|::.:..        |.|.:..|..::|...|.    
Mouse   206 DSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLIMNTIAIQVSTQARQHK 270

  Fly   474 LLKKE--ADKLCG------------RLSQKLNLELSHKIVMDHMPLLMVCLEGLGKLAH--KFPN 522
            |..||  ||.:..            |:.|:|..:.|.::|...:.||..|   ..:.||  |...
Mouse   271 LYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSNC---PAETAHLRKELL 332

  Fly   523 IAGTSI--SYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAV---------QH---SD 573
            ||...|  :.||:..:   |.:.||.|.::...:.....:.|.|...:.         ||   ||
Mouse   333 IAAKHILTTELRNQFI---PCMDKLFDESILIGSGYTARETLRPLAYSTLADLVHHVRQHLPLSD 394

  Fly   574 SRTAVVIYG---DNQKPPGS-------------------GTGRSGHAAFESLRDAAIENLSIALR 616
            ...||.::.   |::..|.|                   ....||:.     ||..:..|.:.:.
Mouse   395 LSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNG-----RDVLMRMLEVFVL 454

  Fly   617 AAHTLDQFCVPALV--ANVSNRLFTAEKS------------------------------------ 643
            ..||:.::.:.|:.  ....:.|..||.:                                    
Mouse   455 KFHTIARYQLSAIFKKCKPQSELGAAEAALPGVPTAPAAPGPAPSPAPVPAPAPPPPPPPAPATP 519

  Fly   644 -------GSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSE----- 696
                   ..|.|||..|.:..:..:......|...:......|..|..      ||.|.|     
Mouse   520 VTPAPVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITS------CKAPGEAQFIP 578

  Fly   697 -------------------QNALIVDQLGC-------MIISQCET-----------H-------- 716
                               ..||.:.|:..       :.::.|:|           |        
Mouse   579 NKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKEEKEVLEHFAGVFTMM 643

  Fly   717 ---VFDEIMK-----MFSRVT----VQSASLAYTSDPEHRKQFHHV-SDAVVNALGNIAANIQGD 768
               .|.||.:     |..|::    :|..:.::.::|.....|..: .:.::..|..:.:|:   
Mouse   644 NPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEYLLERLPEMGSNV--- 705

  Fly   769 AEMLELLGKLLEL-FVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIKNPRQR 832
             |:..|..||.:| |..:.|                ..|.|..||.|       .|..|.|....
Mouse   706 -ELSNLYLKLFKLVFGSVSL----------------FAAENEQMLKP-------HLHKIVNSSME 746

  Fly   833 LHKLFKDFWAYCVVM--------GFTNARLWP------ADWYQGVQQIAAKSPLLISQTAHKSDM 883
            |.:..|:.:.|.:::        |.::..|:.      .:..||:.        ::....||..|
Mouse   747 LAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLN--------MLQSGLHKQHM 803

  Fly   884 RELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEPS 948
            ::|...|.:   :|....|.:|..|....|.:.:|:|.   :|......:..|| |.|:|. :|.
Mouse   804 KDLFVELCL---TVPVRLSSLLPYLPMLMDPLVSALNG---SQTLVSQGLRTLE-LCVDNL-QPD 860

  Fly   949 -----LEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKF----RNVLYAHDEIREKVLESQATL 1004
                 ::|:.:.|.. ||.|........:..||.:|..||    |.:|....::...|.|.|...
Mouse   861 FLYDHIQPVRAELMQ-ALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKESQKLHYVVTEVQGPS 924

  Fly  1005 LLVYFNHIHKPIQMVADQYLSFLVDRF------PHLLWNRRVLW----CMLDILQLL------AY 1053
            :.|.|:.....:|:..::.:...:|..      |:.   ||..|    |.|..:..|      .|
Mouse   925 ITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYY---RRQAWEVIRCFLVAMMSLEDNKHALY 986

  Fly  1054 SLSLDPN--EETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQE 1116
            .|...||  |:|....::|..|..|   ..|||    |.|.   |.:....|....:..|     
Mouse   987 QLLAHPNFTEKTIPNVIISHRYKAQ---DTPAR----KTFE---QALTGAFMSAVIKDLR----- 1036

  Fly  1117 YPNQIP--TPVLAHHSGLALA------------FDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSV 1167
             |:.:|  ..::.|::.:|:|            ..|..|::..|    |:.......|....:..
Mouse  1037 -PSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFH----SEENGSKGMDPLVLIDA 1096

  Fly  1168 LCLRSKY-------AGEISGLLSV--------LSEKDKA---GLADRLVSDVWEACAEKSDARHR 1214
            :.:...|       .||::  |:|        |..|::|   .|...:|..:...|.|::.....
Mouse  1097 IAICMAYEEKELCKIGEVA--LAVIFDVASIILGSKERACQLPLFSYIVERLCACCYEQAWYAKL 1159

  Fly  1215 GAL-------------W---------RATAYLI--ICSEISRKLLHAVASSQLELFTESAMETAV 1255
            |.:             |         :|..:::  :..|:|...: |:|.:.||       :..:
Mouse  1160 GGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAV-AMAKTTLE-------QLLM 1216

  Fly  1256 ECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLA-------------AYEGC 1307
            .|    .|..:|.|..  :|:|.|.:.:|.          .|||.|.             |....
Mouse  1217 RC----ATPLKDEERA--EEIVLAQEKSFH----------HVTHDLVREVTSPNSTVRKQAMHSL 1265

  Fly  1308 KLV------SKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVST 1366
            :::      |..:::.||   .::|.:||...|:                  :|:....|.|:  
Mouse  1266 QVLAQVTGKSVTVIMEPH---KEVLQDMVPPKKH------------------LLRHQPANAQI-- 1307

  Fly  1367 VGCRFKLLQCGLSLLQGNTI-----PK--SLSRNILRERIYSNALDYFCG--------------- 1409
                        .|::|||.     |:  ::..|::..:::...|...|.               
Mouse  1308 ------------GLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCEAEDSALTKLPCYKSL 1360

  Fly  1410 PPTCP---------------NQSREQLLEDIMILLKFWQTMRSE---------KKHL--VTSEV- 1447
            |...|               .||||::   |..|.|...:..||         :|.|  .|.|| 
Mouse  1361 PSLVPLRIAALNALAACNYLPQSREKI---IAALFKALNSTNSELQEAGEACMRKFLEGATIEVD 1422

  Fly  1448 -------------GDY-----DLTNASVSSTQ--------------MLAVRNNPETASLISGGGL 1480
                         |||     ::.|...|.|:              |..:|...|...:...||.
Mouse  1423 QIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQ 1487

  Fly  1481 VNDYTRSMSASGNAVGMGMGVAGGGSSSGW----------------------YNTIPHSTSTLSK 1523
            .:|...|:|..|..           |.|.:                      ::.||.:..||.|
Mouse  1488 RSDGNESLSECGRC-----------SLSPFCQFEPAMEGVEEMKICSAIINLFHLIPAAPQTLVK 1541

  Fly  1524 -------RSNRSKRLQYQ---KDSYDKDYMKKRNLILELLAVE------------LEFL------ 1560
                   ::.|:..::..   ::...|...:..:..:||..:|            :.||      
Mouse  1542 PLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFLKHKDAR 1606

  Fly  1561 ----ITWYNPNSLPDLIVPGEEQIT-------------------------------EW------- 1583
                :...|||....|::||..|..                               .|       
Mouse  1607 PLRDVLAANPNRFITLLLPGGAQTAVRPGSPSTSNMRLDLQFQAIKIISIIVKNDDAWLASQHSL 1671

  Fly  1584 -----------------RNRPYKSTVWRDYARLAWC--------YN------PALAVFLPQRIKN 1617
                             |.....:|.|::...||:|        |.      ..|..|..:.:.|
Mouse  1672 VSQLRRVWVSETFQERHRKENMAATNWKEPKLLAFCLLNYCKRNYGDIELLFQLLRAFTGRFLCN 1736

  Fly  1618 ----AEIIDEEVSR--------------LVCSDP--------IAVCHI----------------- 1639
                .|.::||:.:              :..:||        ..:.||                 
Mouse  1737 MTFLKEYMEEEIPKNYSIAQKRALFFRFVEFNDPNFGDELKAKVLQHILNPAFLYSFEKGEGEQL 1801

  Fly  1640 ----------PEALKYLCTTKNL-LQESPDL-----VYILSWSPV-----------------TPI 1671
                      ||::..:..||.| .::..|:     :|:|.::.:                 :.:
Mouse  1802 LGPPNPEGDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNKNRNSKL 1866

  Fly  1672 QALAYF-------------SRQYPSHPLTAQYAVK--------------TLSSYPAES------- 1702
            :.|..|             :.:|..|.|.|....|              .|.::..|:       
Mouse  1867 RRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEARAIVRQA 1931

  Fly  1703 ---VLPYIPQLV----QALRHDTMGYVVEFIKNISRRSQI-------------VAHQLIWNM--- 1744
               :.|.:|..:    |.|.|.|...:||....:.:...|             |.|.|:.:|   
Mouse  1932 MAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLVQHMVSA 1996

  Fly  1745 -------------QTNMYMD-------------EDQQ---HKDPNLY-EALDQLS--QSIIASFS 1777
                         |..:.:|             :|||   ..|||.. |.::.:|  :.:....:
Mouse  1997 MQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSVSIKRGLSVDSA 2061

  Fly  1778 GAAKRFYEREFDFFGKITAVSGEIRS-------FAKGIERKNACLAALSRIKVQGGCYLPSNPEA 1835
            ...|||....    |.|:||.|..:|       .||.|::::........|:|  .|.:..|.. 
Mouse  2062 QEVKRFRAAT----GAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRV--ACQVNDNTN- 2119

  Fly  1836 MVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAI 1900
                   ::|:|.:..::          ||      ...::.:..|:....:::.|   .|...:
Mouse  2120 -------TAGSPGEVLSR----------RC------VNLLKTALRPDMWCKSELKL---QWFDKL 2158

  Fly  1901 FKVGDDVRQ-----DMLALQVITIFKNIFQQVG-LDLFLFPYRVVATAPGCG---VIECVPNAKS 1956
            ....:...|     ....|:|:.....:.|... |..|....|.:|....||   |:..|.:..|
Mouse  2159 LMTVEQPNQVNYGNICTGLEVLNFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVHSLLS 2223

  Fly  1957 R----DQLGRQTDSGLSEYFQHQ--YGDESSKEFQAARANFVKSMAA--YSLIGYLLQIKDR-HN 2012
            |    ......|.|..|:|.:.:  |. ...|.......|:.|:.:|  ..|.|.|:.:|.. .|
Mouse  2224 RLMSIFPTEPSTSSVASKYEELECLYA-AVGKVIYEGLTNYEKATSANPSQLFGTLMILKSACCN 2287

  Fly  2013 GNIMIDKDGHIIHIDFGFMF------------ESSPGGNIGFEPDMKLTDEMVM----------- 2054
            ....||:   :|.:   ||.            :::.|..   |.....|.|:||           
Mouse  2288 NPSYIDR---LISV---FMRSLQKMVREHLNPQTASGST---EATAAGTSELVMLSLDLVKTRLA 2343

  Fly  2055 IMGGKMDSPAFKWFCELCVQAFLAVRP---YQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVAT 2116
            :|..:|.    |.|.:..:.:.:...|   ...|:|.:|...:....|....||..|.::..:..
Mouse  2344 VMSMEMR----KNFIQTILTSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLV 2404

  Fly  2117 KNNKEAAAHMLAVIRNSYQ---NFRTRTYDMIQY-YQNQ 2151
            |        |:..|...:.   ....:..|::.| |:::
Mouse  2405 K--------MMTYIEKRFPEDLELNAQFLDLVNYVYRDE 2435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 53/353 (15%)
PI4Kc_III_alpha 1836..2153 CDD:270711 64/364 (18%)
TrrapXP_006504844.1 TEL1 <2552..3911 CDD:227365
FAT 2868..3211 CDD:367004
PIKK_TRRAP 3522..3835 CDD:270707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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