DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and pik3ca

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_001119972.1 Gene:pik3ca / 100144924 XenbaseID:XB-GENE-998106 Length:1065 Species:Xenopus tropicalis


Alignment Length:969 Identity:207/969 - (21%)
Similarity:377/969 - (38%) Gaps:226/969 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1261 VLTARQDLELC-------FIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYE---GCKLVSKP-- 1313
            :|.:.:.|:||       :|.::....:...||            :||:.|:   .|.::.:.  
 Frog   232 MLLSSEQLKLCVLEYQGKYILKVCGCDEYLLEK------------YPLSQYKYIRSCIMLGRMPN 284

  Fly  1314 -ILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVG--CRFKLLQ 1375
             :|:|...::.|:..::.....|..|         :....|.:......:.:..:.  .|.|:| 
 Frog   285 LMLMAKDSLYSQIPVDVFTMPSYSRR---------ISTAAPYMNGEASAKSLWAINSTLRIKIL- 339

  Fly  1376 CGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQS-----------REQLLEDIMILL 1429
            |...:   |...:.:.:..:|..||...      .|.|.|.:           .|.||.|:.|  
 Frog   340 CATYV---NVNIRDIDKIYVRTGIYHGV------EPLCDNVNTQRVPCSNPRWNEWLLYDMFI-- 393

  Fly  1430 KFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRN----NPETASLISGGGLVNDYTRSMSA 1490
                                .||..|:.....:.:|:.    ..|...|..|...:.|||.::  
 Frog   394 --------------------PDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTL-- 436

  Fly  1491 SGNAVGMGMGVAGGGSSSGWYNTIPHSTSTL-----SKRSNRSKR---LQYQKDSYD-------- 1539
                      |:|..:.:.|  .:||....|     ...||.:|.   |:.:.|.:.        
 Frog   437 ----------VSGKMALNLW--PVPHGLEDLLNPIGVSGSNPNKETPCLELEFDCFSSPVKFPDM 489

  Fly  1540 ---KDYMKKRNLILELLAVELEFLITWYNPNSLPDLIV-------PGEEQITEWRNRPYKSTVWR 1594
               :|:..|      :|..|:.:.   |:.:.|.:.||       ..:||:....||...|.:..
 Frog   490 TAIEDHANK------VLEREMGYN---YSHSGLSNRIVRENEVRESDKEQLKAISNRDPLSEITE 545

  Fly  1595 DYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEAL-KYLCTTKNLLQESPD 1658
            ......|.:                       ||.|.      :|||.| |.|.:.|...::...
 Frog   546 QEKEFLWSH-----------------------RLYCR------NIPEILPKLLLSVKWNCRDDVS 581

  Fly  1659 LVYIL--SWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVL-PYIPQLVQALRHDTM- 1719
            .:|.|  .|..:.|.||:......||.. :...:||..|..|..:..| .|:.||||.::::.. 
 Frog   582 QMYCLLKEWPAIRPEQAMELLDFNYPDR-IVRSFAVSCLEKYLTDDKLSQYLIQLVQVMKYEQYL 645

  Fly  1720 -GYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRF 1783
             .::|.|:...:..:|.:.|...|.:::.|:            .:.:.|....::.|:..|...:
 Frog   646 DNHLVRFLLKKALVNQRIGHFFFWLLKSEMH------------NKTVSQRFGLLLESYCRACGMY 698

  Fly  1784 YE---REFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSG 1845
            .:   ::.:...|:..::..::...|...:|......:.::|         .|:.|    |...|
 Frog   699 LKHLSKQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMK---------RPDFM----DALQG 750

  Fly  1846 --TPMQSAAKAPYLARFRVYRCGITELETRAMEVS-NNPNSQEDAKMTLGVESWQAAIFKVGDDV 1907
              :|:..|.:   |...|:..|.|.....|.:.:: .||:...: .:.|..|    .|||.|||:
 Frog   751 FTSPLNPAHQ---LGNLRLEECRIMSSAKRPLWLNWENPDIMSE-MLFLNNE----IIFKNGDDL 807

  Fly  1908 RQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYF 1972
            |||||.||:|.|.:||:|..||||.:.||..::.....|:||.|..:.:..|:  |...||....
 Frog   808 RQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRCSHTIMQI--QCKGGLKGAL 870

  Fly  1973 Q------HQYGDESSK--EFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG 2029
            |      ||:..:.:|  .:.||...|.:|.|.|.:..::|.|.||||.|||:..:|.:.|||||
 Frog   871 QFNSHTLHQWLKDKNKGETYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDNGQLFHIDFG 935

  Fly  2030 FMFESSPGGNIGFE----PDMKLTDEMVMIMGGKMD---SPAFKWFCELCVQAFLAVRPYQDAIV 2087
            ...:... ...|::    |.:...|.:::|..|..:   :..|:.|.|:|.:|:||:|.:.:..:
 Frog   936 HFLDHKK-KKFGYKRERVPFVLTQDFLIVISKGIQECTKTRDFERFQEMCYKAYLAIRQHANLFI 999

  Fly  2088 SLVSLMLDTGLPCFRG-QTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMI 2145
            :|.|:||.:|:|..:. ..|..:::.....|..:||..:.:..:.:::....|...|.|
 Frog  1000 NLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWI 1058

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 36/180 (20%)
PI4Kc_III_alpha 1836..2153 CDD:270711 97/329 (29%)
pik3caNP_001119972.1 PI3K_p85B 34..107 CDD:280372
PI3K_rbd 173..292 CDD:295323 13/71 (18%)
C2_PI3K_class_I_alpha 325..484 CDD:176043 37/204 (18%)
PI3Ka_I 525..696 CDD:238444 43/212 (20%)
PI3Kc_IA_alpha 695..1064 CDD:270719 102/388 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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