DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv3 and PKD2L1

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_057196.2	Gene:	PKD2L1 / 9033	HGNCID:	9011	Length:	805	Species:	Homo sapiens

Alignment Length:	740	Identity:	162/740 - (21%)
Similarity:	300/740 - (40%)	Gaps:	163/740 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 KMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGL--QEVYFLNQLFDFI 185
            |....:|.:|..:.:.:..|.......:.|:.|:::::||::..:| ||:  |.:..:...:||.
Human    98 KTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSD-TGVSFQAISSMADFWDFA 161

  Fly   186 ESTLVLA------FNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSD-----T 239
            :..|:.:      :|:.|...||..:.:.| ::||||.|||||:|.|....:......|     .
Human   162 QGPLLDSLYWTKWYNNQSLGHGSHSFIYYE-NMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYD 225

  Fly   240 YYMPD--WQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLA 302
            .|.||  .|||:..  ::...|..:.            ...|..|.|.|.|.||.. .||...|.
Human   226 VYSPDKEEQLPFGP--FNGTAWTYHS------------QDELGGFSHWGRLTSYSG-GGYYLDLP 275

  Fly   303 RSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAK 367
            .|...|.:.:..|.|..||...|..|||||::||.::|||.:..|.||....||.:|..|:.:.|
Human   276 GSRQGSAEALRALQEGLWLDRGTRVVFIDFSVYNANINLFCVLRLVVEFPATGGAIPSWQIRTVK 340

  Fly   368 LLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEPHL-----LKSVWNKLDLFIFMVNVLVV 427
            |:..|....:. ::...:...|||.:   ..|:...|.|:     |.|:||.|||.:.:::::.|
Human   341 LIRYVSNWDFF-IVGCEVIFCVFIFY---YVVEEILELHIHRLRYLSSIWNILDLVVILLSIVAV 401

  Fly   428 VLVVLR----ESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFAS 488
            ...:.|    ..|:..::::....:..||:.|.: ::.:.:..:.:.|    ..:::::.:.|..
Human   402 GFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQ-TQYNNMNAVNLFF----AWIKIFKYISFNK 461

  Fly   489 VFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVV--TINGNYSSNFNKLVK---SMVMCMCYSF 548
            .....:.|  ||..|......|::.|::.|.:|.:  .:.|....||:..:|   :....:...|
Human   462 TMTQLSST--LARCAKDILGFAVMFFIVFFAYAQLGYLLFGTQVENFSTFIKCIFTQFRIILGDF 524

  Fly   549 GFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFT------------------ 595
            .::|      :.:..:.||...:....|.:..:|:|:|:::|||.::
Human   525 DYNA------IDNANRILGPAYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKDELQLSDL 583

  Fly   596 ---------------------VAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRN 639
                                 |.|.::..|:|.:...|...:.|.........:|......:.|:
Human   584 LKQGYNKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTLRELGHAEHEITELTATFTKFDRD 648

  Fly   640 GRTVAENVSRKLDSMDRQRLMRRRLRQ------------GRHHVSRP--------------VSAE 678
            |       :|.||..:::: ||:.|.:            ||..||.|              ||.|
Human   649 G-------NRILDEKEQEK-MRQDLEEERVALNTEIEKLGRSIVSSPQGKSGPEAARAGGWVSGE 705

  Fly   679 D------ALLEYKDRGDKMVNVHYILNIQLTLIRMFLFDEYVEW------PQEQQ--KQPE---A 726
            :      .:|:.:...:.:|:....:..:|.::      |...|      .:||.  |.|:   |
Human   706 EFYMLTRRVLQLETVLEGVVSQIDAVGSKLKML------ERKGWLAPSPGVKEQAIWKHPQPAPA 764

  Fly   727 QDPDPNLGPDGSPPQD---KRQDEA 748
            ..||| .|..|....:   ||::||
Human   765 VTPDP-WGVQGGQESEVPYKREEEA 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	111/453 (25%)
PKD2L1	NP_057196.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59
		PKD_channel	147..567	CDD:400395	109/452 (24%)
		Fer4_24	702..735	CDD:407943	5/32 (16%)
		Required for homooligomerization	704..763		10/64 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..805		11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820