DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and Pkd1l2

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_036010263.1	Gene:	Pkd1l2 / 76645	MGIID:	2664668	Length:	2466	Species:	Mus musculus

Alignment Length:	696	Identity:	154/696 - (22%)
Similarity:	249/696 - (35%)	Gaps:	151/696 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAMFAITVGIIIGCMICIAVFA---GFQHEDVKFKTMLVSIVIVLIFQFLIGDPIK------FVI 63
            |.:.|.|.|:       .|.|.   |..:..|.....|:|:.:..:....|..|:|      |..
Mouse  1827 WLLVATTSGV-------AAFFTMLYGLHYGRVSSLKWLISMAVSFVESVFITQPLKVLGFAAFFA 1884

  Fly    64 LSIDR-------ALWP-------------------PRIYIPPRCDKDEMDEKEERRDFLKQRLIN 102
            |.:.|       .|:|                   .|.|.||                 ....|.
Mouse  1885 LVLKREDDEETLPLFPGHLSSPGPGVLFRSRRHSSERAYQPP-----------------PMAAIE 1932

  Fly   103 KRANLMLTSRYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHT 167
            |    |.|:|.:..|   .:.:| .::..|..:...|:.:....||...||..|.:...|.
Mouse  1933 K----MKTTRLKEQK---AFALI-REILAYLAFLWMLLLVAYGQRDPNAYHFHRHLERSFS---- 1985

  Fly   168 DYTGLQEVYFLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQ---- 228
              .|...|......|::..:|||     .:.....||:.....|.|:|...:||:||....
Mouse  1986 --QGFSPVLGFRGFFEWANTTLV-----KNLYGHHPGFVTDGNSKLVGSAHIRQVRVRESSCAVA 2043

  Fly   229 -------------VGLGPPKFSDTYYMPDWQL-PYRKLHYSDKYWRI--------YEPWIPIKMG 271
                         ..||.....|  |...|.. .|...:...:.||.        |..|
Mouse  2044 QQLQDSLDGCHGPYSLGIEDLVD--YGEGWNASAYNNSNGFPQAWRYQSQSQRRGYPMW------ 2100

  Fly   272 FEFLDALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYN 336
                          |.|..|.. .|||..|.....::.:::.||.:|.||...|.|||::||:||
Mouse  2101 --------------GKLTLYGG-GGYVVPLGTDHQSASRILQYLFDNSWLDALTRAVFVEFTVYN 2150

  Fly   337 VDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKL 401
            .:||||...||.:|.:..|.....|.:.|.:|....|......:.|.|.|.| |:.:...:..||
Mouse  2151 ANVNLFCTVTLTLETSGLGTFFSHVTLQSLRLYPFTDGWHPFVVAAELTYFL-FLFYYMVVQGKL 2214

  Fly   402 -----WYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRM 461
                 |   ....|.||.|::.|.:.:...:|:.|.|..|....:::.. ..:.|.|.|...:..
Mouse  2215 MRKQKW---GYFCSKWNLLEVAIILASWSALVVFVKRTILADRDLQRYR-EHRDEGISFSETAAA 2275

  Fly   462 HQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTIN 526
            .......|.||:.::|::||.:|:......:.|..|..||..::.....|:|.|:.:.||...:.
Mouse  2276 DAALGYIIAFLVLLSTVKLWHLLRLNPKMNMITSALRRAWGDISGFVAVILIMLLAYSFASNLVF 2340

  Fly   527 G----NYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFV 587
            |    :|.:.|: ..::||......|.:...:..|.:      ||.|..|.....:..:::|:|:
Mouse  2341 GWKLRSYKTLFD-AAETMVSLQLGIFNYEEVLDYSPI------LGSLLIGSCIVFMTFVVLNLFI 2398

  Fly   588 SLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLG-RFRKLPCW 632
            |:|...|:..:.......|..|.  :.|:|:....|| |.::...|
Mouse  2399 SVILVAFSEEQKSDQLWEEGEIA--DLLLVKILSFLGIRCKREETW 2442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	108/459 (24%)
Pkd1l2	XP_036010263.1	CLECT	28..154	CDD:214480
		Gal_Lectin	170..252	CDD:396628
		REJ	493..866	CDD:366875
		GPS	1282..1321	CDD:396408
		PLAT_polycystin	1392..1511	CDD:238850
		PKD_channel	1987..2407	CDD:400395	109/459 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020