Protein Alignment brv3 and pkd2l1

DIOPT Version :10

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_695404.4
• Gene: pkd2l1 / 567026
• ZFINID: ZDB-GENE-030616-558
• Length: 862
• Species: Danio rerio
• Alignment Length: 715
• Identity: 155/715 - (21%)
• Similarity: 296/715 - (41%)
• Gaps: 170/715 - (23%)

  Fly    92 RRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVL--VTRDQTLYHN 154
            |:|..:...:|.:|||                   .:|.|| ..||..:||:.  :|...|.|:
Zfish   150 RKDTKENPELNVKANL-------------------KELLIY-IVFLVDLCLLTYGMTSSATYYY- 193

  Fly   155 TRIITDLFMYNHTDYTGL--QEVYFLNQLFDFIESTLV------LAFNSNSTESGSPGWAHAEQS 211
            |:.:||||: |.....|:  ..:..:|.::.::|..|:      ..:|....|:|:..:.:.| :
Zfish   194 TKAMTDLFV-NLPGSNGMSFSSIGCMNDVWTYMEGPLLDNLYWTKWYNDEPLENGNQSFIYYE-N 256

  Fly   212 VLLGVMRLRQLRVSNPQVGLGPPKFS-------DTYYMPD-------------WQLPYRKLHYSD 256
            :||||.|:|||:|......: |..|.       |.|.:..             ||      ::|:
Zfish   257 LLLGVPRVRQLKVKQNSCKV-PTDFKKEISDCFDVYNIKKEDDGAFGLINGTAWQ------YHSE 314

  Fly   257 KYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWL 321
            |.                    :....|.|.|.:|.. ||:...|..:...|..:::.|.||.||
Zfish   315 KE--------------------IKGSSHWGLLTTYSG-AGFYQDLTTTRDESAALLEDLRENLWL 358

  Fly   322 TLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGL---LAL 383
            ...|..:|||||.||.::|||.:..|.||....||.:|..|:.:.||:..|....|..:   :..
Zfish   359 DRGTRVLFIDFTAYNANINLFCVIRLVVEFPATGGAIPSYQIRTVKLIRYVTTWDYFIIGCEIVF 423

  Fly   384 LIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLR----ESLVASMMKKV 444
            .:::|.:| ..:.|..::....| ..|:||.||:.:.::.|:.:|....|    :.|:.:::|:.
Zfish   424 CVFILYYI-VEEILEFRIHKLSH-FTSIWNILDIVVILLAVVAIVFSAFRTIKVDGLLGNLLKQP 486

  Fly   445 EGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAI 509
            :..:..||:.|.: ::.:.:..:.:.|    ..:::::.:.|.......|.|  ||..|:.....
Zfish   487 DIYADFEFLAFWQ-TQYNNMNAVNLFF----AWIKIFKYISFNKTMTQLTST--LARCALDIFGF 544

  Fly   510 AIVIFLIGFCFA----------VVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGK 564
            ||:.|::.|.:|          |.|.     |.|||.:.:....:...|.:.|      :....:
Zfish   545 AIMFFIVFFAYAQLGYLLFGTEVETF-----STFNKCIFTQFRIILGDFDYDA------IDRANR 598

  Fly   565 WLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEF--SGVLGRFR 627
            .||.:.:....|.:..:|:|:|:::|||.::..|:...|:::      ||.:.:.  ......|.
Zfish   599 VLGPIYFFSYVFFVFFVLLNMFLAIINDTYSEVKSELASQKD------EFQIADLIKQSYAKTFM 657

  Fly   628 KLPCWRRNYVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHVSRPVSAEDALLEYKDRGDKMV 692
            ||.. ::..:.:.:...::.:.:|:..|    .|..|:: ..|..|.:||  |..::...|::.:
Zfish   658 KLKL-KKEKISDVQKALDSGASELEFKD----FRNALKE-MGHSDREISA--AFSKFDQDGNQTL 714

  Fly   693 NVHYILNIQLTLIRMFLFDEYVEWPQEQQKQ----------PEAQDPDPNLGP-----DGSPPQD 742
            :                     :..||..||          .|.:|.:.::.|     :..||:|
Zfish   715 D---------------------KQEQENMKQELEEKRDALSAELRDLENSVEPAEEHRNTVPPED 758

  Fly   743  742
            Zfish   759  758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	Polycystin_dom	171..369	CDD:466668	57/225 (25%)
		PKD_channel	370..595	CDD:462341	48/241 (20%)
pkd2l1	XP_695404.4	None