DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv3 and pkd1b

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_021335980.1	Gene:	pkd1b / 565697	ZFINID:	ZDB-GENE-100707-2	Length:	4007	Species:	Danio rerio

Alignment Length:	812	Identity:	149/812 - (18%)
Similarity:	273/812 - (33%)	Gaps:	228/812 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WA--MFAITVGIIIGCMICIAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDRAL 70
            |.  |..:.|.:::|..:.:....|...........|||.:..::...|:.:|:...|    :||
Zfish  3160 WVLRMVHLLVAVLLGTCLAVVGLYGSSFTSSVVLMWLVSTLSAVLTSALLLEPLAICI----QAL 3220

  Fly    71 WPPRIYIP--PRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYG 133
            :...:..|  |..::....|.|.||.                        .:.::...|.|..||
Zfish  3221 YLATVVRPVDPEVEERLAQETEVRRS------------------------EEDFRDKVHPLCGYG 3261

  Fly   134 PY-------------FLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYFLNQLFDFI 185
            ..             .|...|||.:.          .:..:.|.|:.::..:.:   ..:|...|
Zfish  3262 LLQAKEEARKLRTLRALMRSCLVYML----------FLLVVLMVNYQEHVQMAD---SRRLHSAI 3313

  Fly   186 ESTLVLAFNSNSTESGSP------GWAHAEQSVLLGVMRLRQLRVSNPQVGL-GPPKFSDTYYMP 243
            :.||:      |..:|.|      ||.:|||.:   ..:|......||.:.| ||.:....|:..
Zfish  3314 KHTLI------SASAGKPGLMKLSGWMNAEQWI---NEKLTSHLYENPSLLLTGPARLQKVYFQD 3369

  Fly   244 DWQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGS------------LNSYPELAG 296
            ......|....|.:                   ..||...||.|            ..:.|.|:.
Zfish  3370 FCSQGIRDQFQSGR-------------------LSLMPTAHVSSHANPGQQTSTAHSKNTPALST 3415

  Fly   297 YVS------------LLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRV 349
            :..            :|..:...:.:::..|.:..|:|..|.||.|:||.|:...::.:..::.:
Zfish  3416 WQKRALCAFSQTEELVLGNNTEYTRQILSDLQKEKWMTTGTKAVLIEFTQYHKQTSILAPVSILL 3480

  Fly   350 EKTPFGGIVPDVQVDSAKL--LENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEP-HLLKSV 411
            ::|..|.|:..:.:....:  |...| :..|..:.||::.|.|:   .|....|..:| ..|:..
Zfish  3481 DQTQTGRILAFISIQPFHISPLSGPD-LHVTLTVVLLLFALCFL---STEVRALIRKPSQYLRQA 3541

  Fly   412 WNKLDLFIFMVNVLVVVLVVLR------ESLVASMMKKVEGASKMEFIDFRRPS----RMHQLTT 466
            |   ..|..::.:|.:...|||      .::..|..:.:..:    |.||...:    :.:||:.
Zfish  3542 W---CWFQTLLALLALAAAVLRLYFLYTTTVCISRYRSIPSS----FADFHSAATVARKSNQLSA 3599

  Fly   467 ITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSS 531
            |    |:.:..|::..:|||...:.:..|.::..:..:......:::.|:.|....:.:......
Zfish  3600 I----LLTLLALKMVGILQFVRRWLVMGRVIWQVFPQICGVVFLLLLLLLLFSHIGMMLFSGSVE 3660

  Fly   532 NFNKLVKSMVMCMCYSFGFSAQVKPSELFHG-------------GKW-LGILCYGVLAFVIIVLL 582
            .|..|.::....:|...|.:...:..| .|.             |.| ||.||..|
Zfish  3661 GFRTLGQASSSLLCLLRGRTGLQRLCE-HHPVVGPLYCLSAVGIGFWVLGRLCAAV--------- 3715

  Fly   583 INVFVSLINDYFTV-AKTIRDSERENRITFFEFLV------------------VEFSGVLGRFRK 628
                  ||..|..| |...|.|.........:||:                  |:|.|:    |.
Zfish  3716 ------LIRTYQMVQADIYRPSMEPQDYEMVQFLIKRLKLWMGLSKTKEFRHRVKFEGM----RP 3770

  Fly   629 LP-----------CW--------RRNYVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHVSRP 674
            .|           ||        |:..:.:..::|.:.|...||.|           ...:|.|.
Zfish  3771 PPSRSSQVSASSNCWTPLSPIGSRQTLLSSASSLASDTSVISDSCD-----------VHPYVERL 3824

  Fly   675 VSAEDALLEYKDRGDKMVNVHYILNIQLTLIR 706
            |...|:||...:|.:::....|...:||..|:
Zfish  3825 VPCVDSLLAGFERVNQVTEEVYNFELQLQQIQ 3856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	90/482 (19%)
pkd1b	XP_021335980.1	PCC	25..2314	CDD:188093
		GPS	2590..2636	CDD:321989
		PLAT_polycystin	2697..2815	CDD:238850
		PKD_channel	3302..3720	CDD:332708	89/479 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820