DRSC/TRiP Functional Genomics Resources

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Protein Alignment brv3 and PKD2

DIOPT Version :9

Sequence 1:NP_001284831.1 Gene:brv3 / 31246 FlyBaseID:FBgn0040333 Length:750 Species:Drosophila melanogaster
Sequence 2:NP_000288.1 Gene:PKD2 / 5311 HGNCID:9009 Length:968 Species:Homo sapiens


Alignment Length:723 Identity:154/723 - (21%)
Similarity:289/723 - (39%) Gaps:143/723 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 RALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIY 132
            |.||..|:          |:|....|:                 :|        .|.:..:|..|
Human   198 RGLWGTRL----------MEESSTNRE-----------------KY--------LKSVLRELVTY 227

  Fly   133 GPYFLCLMCLVLVTRDQTLYHNTRIITDLFM---YNHTDYTGLQEVYFLNQLFDFIESTLVLAF- 193
            ..:.:.|..|........:|:.||:::.||:   .:.|:.|..:.:..:...:.|.|.:|:... 
Human   228 LLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLY 292

  Fly   194 ----NSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLHY 254
                .||.||:.:..:...| ::||||.|:|||||.|....: |....|..          |..|
Human   293 WKMQPSNQTEADNRSFIFYE-NLLLGVPRIRQLRVRNGSCSI-PQDLRDEI----------KECY 345

  Fly   255 SDKYWRIYEPWIPI--KMGFEFL---DALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVIDY 314
             |.|....|...|.  :.|..::   :..|....|.|.:.:|.. |||...|:|:...:...:..
Human   346 -DVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG-AGYYLDLSRTREETAAQVAS 408

  Fly   315 LSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTG 379
            |.:|.||...|.|.||||::||.::|||.:..|.||....||::|..|....||:..|....:  
Human   409 LKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDF-- 471

  Fly   380 LLALLIYVLVFIQF----AQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASM 440
            .||....:..|..|    .:.|.::: ::.|..:|.||.||:.|.:::|:.:.:.:.|.|.|..:
Human   472 FLAACEIIFCFFIFYYVVEEILEIRI-HKLHYFRSFWNCLDVVIVVLSVVAIGINIYRTSNVEVL 535

  Fly   441 MKKVEGASKMEFIDFRRPS----RMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAW 501
            ::.:|  .:..|.:|...:    :.:.:..:|:.|:    .::|::.:.|.......:.|:....
Human   536 LQFLE--DQNTFPNFEHLAYWQIQFNNIAAVTVFFV----WIKLFKFINFNRTMSQLSTTMSRCA 594

  Fly   502 SAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFG-FSAQVKPSELFHGGKW 565
            ..:...||...|..:.:......:.|....:|:...:    |:...|. ....:..:|:....:.
Human   595 KDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQE----CIFTQFRIILGDINFAEIEEANRV 655

  Fly   566 LGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLP 630
            ||.:.:....|.:..:|:|:|:::|||.::..|:....::..         :|.|.::       
Human   656 LGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQKAE---------MELSDLI------- 704

  Fly   631 CWRRNY------VRNGRTVAENVSRKLDSMDRQ---RLMRRRLRQ---GRHHVSRPVSAEDALLE 683
              |:.|      ::..:...:::|..|    ||   :|....|||   |:.|....:.|  ...:
Human   705 --RKGYHKALVKLKLKKNTVDDISESL----RQGGGKLNFDELRQDLKGKGHTDAEIEA--IFTK 761

  Fly   684 YKDRGDKMVNVHYILNIQLTLIRMFLFDEYVEWPQEQQKQPEAQDPD----PNLGPDGSPPQ--- 741
            |...||:.:..|                |:.:...:.:|:.|..|.|    |......|.|:   
Human   762 YDQDGDQELTEH----------------EHQQMRDDLEKEREDLDLDHSSLPRPMSSRSFPRSLD 810

  Fly   742 DKRQDEAE 749
            |..:|:.|
Human   811 DSEEDDDE 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv3NP_001284831.1 PKD_channel 170..595 CDD:285288 104/443 (23%)
PKD2NP_000288.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 58..181
PKD_channel 269..687 CDD:400395 103/444 (23%)
Selectivity filter. /evidence=ECO:0000305|PubMed:28092368 641..643 0/1 (0%)
EFh_HEF <724..792 CDD:355006 19/89 (21%)
EF-hand motif 754..782 CDD:320075 6/45 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..831 14/71 (20%)
Linker. /evidence=ECO:0000305|PubMed:18694932 803..822 5/16 (31%)
Important for interaction with PACS1 and PACS2. /evidence=ECO:0000269|PubMed:15692563 810..821 3/9 (33%)
Fer4_24 834..868 CDD:407943
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 917..968
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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