Protein Alignment brv3 and PKD1

DIOPT Version :10

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_047290164.1
• Gene: PKD1 / 5310
• HGNCID: 9008
• Length: 4348
• Species: Homo sapiens
• Alignment Length: 831
• Identity: 167/831 - (20%)
• Similarity: 292/831 - (35%)
• Gaps: 240/831 - (28%)

  Fly     8 WAMFAITVGIIIGCMIC-----IAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSID 67
            |...:...|:.:..::.     :|.|.|::    ..|.:|.::...|:.:.|..|....::.|
Human  3620 WVGASFPPGVSVAWLLSSSASFLASFLGWE----PLKVLLEALYFSLVAKRLHPDEDDTLVES-- 3678

  Fly    68 RALWP-----PRIYIPPR-----CDKDEMDEKEERRDFLKQRLINKRANLM-LTSRYRN------ 115
            .|:.|     ||:. ||.     ..|:|..:.:.....|:..|:.....|: |.:.|.:
Human  3679 PAVTPVSARVPRVR-PPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGH 3742

  Fly   116 -YKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYFLN 179
             |:|....|...|.           ...:.:||.:.|:                      .:..:
Human  3743 AYRLQSAIKQELHS-----------RAFLAITRSEELW----------------------PWMAH 3774

  Fly   180 QLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGP----PK----- 235
            .|..::..      |.:|.|.|.|              ||||:|:   |..|.|    |:
Human  3775 VLLPYVHG------NQSSPELGPP--------------RLRQVRL---QEALYPDPPGPRVHTCS 3816

  Fly   236 ----FSDTYYMPDWQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAG 296
                ||.:.|...|:.|    |.....|....|        :.|.|...     ||...| :..|
Human  3817 AAGGFSTSDYDVGWESP----HNGSGTWAYSAP--------DLLGAWSW-----GSCAVY-DSGG 3863

  Fly   297 YVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDV 361
            ||..|..|...|...:.:|..::||...:.|||::.|.|:..|.|.:..|||:| .|..|
Human  3864 YVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLE-FPAAG----- 3922

  Fly   362 QVDSAKLLENVDQMPY------TGLLALLIYVLVFIQFAQTLAV---KLWYEPHLLKSVWNKLDL 417
                 :.|..:...|:      .||...|:..:..:.||...||   :.|:.    :..|..|.|
Human  3923 -----RALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHR----EGRWRVLRL 3978

  Fly   418 FIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDF--RRPSR------MHQLTTITIGF--- 471
            ..:...:||.:........:|.:     ||:..::..|  .||.|      :.||::...|.
Human  3979 GAWARWLLVALTAATALVRLAQL-----GAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAAS 4038

  Fly   472 LICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFC-FAVVTINGNYSSNFNK 535
            |:.:..::..:.|:|...:.:|.:||..|...:....:.:|:..:.:. .|::.::....|.::
Human  4039 LLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWS- 4102

  Fly   536 LVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVI-------IVLLINVFVSLINDY 593
             |...::.:|...|.|. :.|:|.:|...   :||.|:.|..:       .|:|...:.:|..:.
Human  4103 -VAQALLVLCPGTGLST-LCPAESWHLSP---LLCVGLWALRLWGALRLGAVILRWRYHALRGEL 4162

  Fly   594 FTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWR--------RNYVR------------ 638
            :..|...:|.|           :||..     .|:|..|.        |:.||
Human  4163 YRPAWEPQDYE-----------MVELF-----LRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSS 4211

  Fly   639 NGRTVAENV---------------SRKLD--SMDRQRLMRRRLRQGRHHVSRPVSAEDALLEYKD 686
            .|..|:.:|               |.:||  |:...||..|    .....||..:..:|||...|
Human  4212 RGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTR----CEPEPSRLQAVFEALLTQFD 4272

  Fly   687 RGDKMVNVHYILNIQLTLIRMFLFDEYVEWPQEQQKQP--EAQDPDPNLGP 735
            |.::.....|.|..||..::          .:...:.|  .::.|.|.|.|
Human  4273 RLNQATEDVYQLEQQLHSLQ----------GRRSSRAPAGSSRGPSPGLRP 4313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	Polycystin_dom	171..369	CDD:466668	50/210 (24%)
		PKD_channel	370..595	CDD:462341	48/252 (19%)
PKD1	XP_047290164.1	PPP1R42	<54..127	CDD:455733
		leucine-rich repeat	70..92	CDD:275378
		leucine-rich repeat	93..116	CDD:275378
		PCC	97..2773	CDD:188093
		leucine-rich repeat	117..129	CDD:275378
		GPS	3056..3105	CDD:470616
		PLAT_polycystin	3163..3282	CDD:238850
		Polycystin_dom	3758..3936	CDD:466668	55/251 (22%)
		PKD_channel	3937..4158	CDD:462341	46/235 (20%)