DRSC/TRiP Functional Genomics Resources

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Protein Alignment brv3 and PKD1

DIOPT Version :9

Sequence 1:NP_001284831.1 Gene:brv3 / 31246 FlyBaseID:FBgn0040333 Length:750 Species:Drosophila melanogaster
Sequence 2:XP_024306066.1 Gene:PKD1 / 5310 HGNCID:9008 Length:4343 Species:Homo sapiens


Alignment Length:831 Identity:167/831 - (20%)
Similarity:292/831 - (35%) Gaps:240/831 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 WAMFAITVGIIIGCMIC-----IAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSID 67
            |...:...|:.:..::.     :|.|.|::    ..|.:|.::...|:.:.|..|....::.|  
Human  3615 WVGASFPPGVSVAWLLSSSASFLASFLGWE----PLKVLLEALYFSLVAKRLHPDEDDTLVES-- 3673

  Fly    68 RALWP-----PRIYIPPR-----CDKDEMDEKEERRDFLKQRLINKRANLM-LTSRYRN------ 115
            .|:.|     ||:. ||.     ..|:|..:.:.....|:..|:.....|: |.:.|.:      
Human  3674 PAVTPVSARVPRVR-PPHGFALFLAKEEARKVKRLHGMLRSLLVYMLFLLVTLLASYGDASCHGH 3737

  Fly   116 -YKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYFLN 179
             |:|....|...|.           ...:.:||.:.|:                      .:..:
Human  3738 AYRLQSAIKQELHS-----------RAFLAITRSEELW----------------------PWMAH 3769

  Fly   180 QLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGP----PK----- 235
            .|..::..      |.:|.|.|.|              ||||:|:   |..|.|    |:     
Human  3770 VLLPYVHG------NQSSPELGPP--------------RLRQVRL---QEALYPDPPGPRVHTCS 3811

  Fly   236 ----FSDTYYMPDWQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAG 296
                ||.:.|...|:.|    |.....|....|        :.|.|...     ||...| :..|
Human  3812 AAGGFSTSDYDVGWESP----HNGSGTWAYSAP--------DLLGAWSW-----GSCAVY-DSGG 3858

  Fly   297 YVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDV 361
            ||..|..|...|...:.:|..::||...:.|||::.|.|:..|.|.:..|||:| .|..|     
Human  3859 YVQELGLSLEESRDRLRFLQLHNWLDNRSRAVFLELTRYSPAVGLHAAVTLRLE-FPAAG----- 3917

  Fly   362 QVDSAKLLENVDQMPY------TGLLALLIYVLVFIQFAQTLAV---KLWYEPHLLKSVWNKLDL 417
                 :.|..:...|:      .||...|:..:..:.||...||   :.|:.    :..|..|.|
Human  3918 -----RALAALSVRPFALRRLSAGLSLPLLTSVCLLLFAVHFAVAEARTWHR----EGRWRVLRL 3973

  Fly   418 FIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDF--RRPSR------MHQLTTITIGF--- 471
            ..:...:||.:........:|.:     ||:..::..|  .||.|      :.||::...|.   
Human  3974 GAWARWLLVALTAATALVRLAQL-----GAADRQWTRFVRGRPRRFTSFDQVAQLSSAARGLAAS 4033

  Fly   472 LICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFC-FAVVTINGNYSSNFNK 535
            |:.:..::..:.|:|...:.:|.:||..|...:....:.:|:..:.:. .|::.::....|.:: 
Human  4034 LLFLLLVKAAQQLRFVRQWSVFGKTLCRALPELLGVTLGLVVLGVAYAQLAILLVSSCVDSLWS- 4097

  Fly   536 LVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVI-------IVLLINVFVSLINDY 593
             |...::.:|...|.|. :.|:|.:|...   :||.|:.|..:       .|:|...:.:|..:.
Human  4098 -VAQALLVLCPGTGLST-LCPAESWHLSP---LLCVGLWALRLWGALRLGAVILRWRYHALRGEL 4157

  Fly   594 FTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWR--------RNYVR------------ 638
            :..|...:|.|           :||..     .|:|..|.        |:.||            
Human  4158 YRPAWEPQDYE-----------MVELF-----LRRLRLWMGLSKVKEFRHKVRFEGMEPLPSRSS 4206

  Fly   639 NGRTVAENV---------------SRKLD--SMDRQRLMRRRLRQGRHHVSRPVSAEDALLEYKD 686
            .|..|:.:|               |.:||  |:...||..|    .....||..:..:|||...|
Human  4207 RGSKVSPDVPPPSAGSDASHPSTSSSQLDGLSVSLGRLGTR----CEPEPSRLQAVFEALLTQFD 4267

  Fly   687 RGDKMVNVHYILNIQLTLIRMFLFDEYVEWPQEQQKQP--EAQDPDPNLGP 735
            |.::.....|.|..||..::          .:...:.|  .::.|.|.|.|
Human  4268 RLNQATEDVYQLEQQLHSLQ----------GRRSSRAPAGSSRGPSPGLRP 4308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv3NP_001284831.1 PKD_channel 170..595 CDD:285288 99/465 (21%)
PKD1XP_024306066.1 LRR <50..>126 CDD:227223
leucine-rich repeat 70..92 CDD:275378
leucine-rich repeat 93..116 CDD:275378
PCC 97..2768 CDD:188093
leucine-rich repeat 117..129 CDD:275378
GPS 3051..3100 CDD:197639
PLAT_polycystin 3158..3277 CDD:238850
PKD_channel 3751..4153 CDD:332708 101/501 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3599
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1276906at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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