Protein Alignment brv3 and Pkd2

DIOPT Version :9

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: NP_001178863.1
• Gene: Pkd2 / 498328
• RGDID: 1559992
• Length: 966
• Species: Rattus norvegicus
• Alignment Length: 665
• Identity: 145/665 - (21%)
• Similarity: 271/665 - (40%)
• Gaps: 117/665 - (17%)

  Fly    68 RALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIY 132
            |.||..|:          |:|....|:                 :|        .:.:..:|..|
  Rat   196 RGLWGTRL----------MEESNANRE-----------------KY--------LRSVLRELVTY 225

  Fly   133 GPYFLCLMCLVLV-TRDQTLYHNTRIITDLFM---YNHTDYTGLQEVYFLNQLFDFIESTLV--- 190
             .:||.|:|::.. .....:|:.||.::.||:   .:.|:.|..:.:..:...:.|.|.:.:
  Rat   226 -LFFLILLCILTYGMMSSNVYYYTRTLSQLFIDTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGL 289

  Fly   191 --LAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLH 253
              .|.:||.|::.:..:...| ::||||.|||||||.|....: |....|..          |..
  Rat   290 YWKAQSSNHTQADNRSFIFYE-NLLLGVPRLRQLRVRNGSCSI-PQDLRDEI----------KEC 342

  Fly   254 YSDKYWRIYEPWIPI--KMGFEFL---DALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVID 313
            | |.|....|...|.  :.|..::   :..|....|.|.:.:|.. |||...|:|:...:...:.
  Rat   343 Y-DVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSG-AGYYLDLSRTREETAAQLA 405

  Fly   314 YLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYT 378
            .|..|.||...|.|.||||::||.::|||.:..|.||....||:||..|....||:..|....:
  Rat   406 GLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLVEFPATGGVVPSWQFQPVKLIRYVTAFDF- 469

  Fly   379 GLLA----LLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVAS 439
             .||    :..:.:::....:.|.::: :..:..:|.||.||:.|.:::|:.:::.:.|.|....
  Rat   470 -FLAACEIIFCFFILYYVVEEILEIRI-HRLNYFRSFWNCLDVVIVVLSVVAMMINIYRMSNAEG 532

  Fly   440 MMKKVEGASKMEFIDFRRPS----RMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLA 500
            :::.:|  .:..|.:|...:    :.:.:..:.: ||:.|   :|::.:.|.......:.|:...
  Rat   533 LLQFLE--DQNSFPNFEHVAYWQIQFNNIAAVMV-FLVWI---KLFKFINFNRTMSQLSTTMSRC 591

  Fly   501 WSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFG-FSAQVKPSELFHGGK 564
            ...:....|...|..:.:......:.|....:|:...:    |:...|. ....:..:|:....:
  Rat   592 AKDLFGFTIMFFIIFLAYAQLAYLVFGTQVDDFSTFQE----CIFTQFRIILGDINFAEIEEANR 652

  Fly   565 WLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKT-----------------------IRDSERE 606
            .||.|.:....|.:..:|:|:|:::|||.::..|:                       ::...:.
  Rat   653 VLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQKALVKLKLKR 717

  Fly   607 NRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVA--ENVSRKLDSMDRQRLMRRRLRQGRH 669
            |.:......:.:..|.| .|.:|   |::....|.|.|  |.:..|.|....|.|..|..:|.|.
  Rat   718 NTVDAISESLRQGGGKL-NFDEL---RQDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQMRD 778

  Fly   670 HVSRPVSAEDALLEY 684
            .:.|  ..||..||:
  Rat   779 DLER--EREDLDLEH 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	102/443 (23%)
Pkd2	NP_001178863.1	PKD_channel	265..685	CDD:285288	102/446 (23%)
		EFh	730..776	CDD:298682	14/49 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810