DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and pkd1l2a

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_017212723.2	Gene:	pkd1l2a / 497373	ZFINID:	ZDB-GENE-050208-89	Length:	2484	Species:	Danio rerio

Alignment Length:	661	Identity:	145/661 - (21%)
Similarity:	258/661 - (39%)	Gaps:	95/661 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAMFAITVGIIIGCMICIAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDRALWP 72
            |.:...|.|:    .....:..|..:...:..:.|:|:|:.......|..|:|.:..::..||
Zfish  1854 WFLVLATSGV----SAYFTMLYGLTYGKERSISWLISMVVSFFESLFITQPVKVLGFAVFFAL-- 1912

  Fly    73 PRIYIPPRCDKDEMDE----------------KEERRD----FLK---QRLINKRANLMLTSRYR 114
                :....|:||..:                :..|||    |.|   ...|.|..|.|:
Zfish  1913 ----VLKTVDQDEYGDVSIDGTLSNTDDPDAVRIARRDSTCSFYKPPPPTDIEKMRNNMI----- 1968

  Fly   115 NYKLNDQYKMIA--HDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYF 177
                 .:.|:.|  .::.||..:...|:.:....||...|:.|..|...|.      ||:.|...
Zfish  1969 -----KEQKVFALIREILIYVGFLWMLLLVAYGQRDPNAYYLTHHIRQSFS------TGISETLN 2022

  Fly   178 LNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYM 242
            ...:|.:..|:|:     .:.....||:.....|.|:|..|:||:||......:..|.   .|.:
Zfish  2023 HKDIFIWANSSLL-----RNLYGQYPGFITDGNSKLVGNARIRQVRVRRDTCKIANPM---QYSV 2079

  Fly   243 PDWQLPY-----------------RKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNS 290
            .|...||                 |.::.|.   .:.:||      :....|.|......|.|..
Zfish  2080 RDCHAPYSWESEDMGSYSPGWNQTRNVNGSK---TVLKPW------YYQTQAKLRANPVWGGLAL 2135

  Fly   291 YPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFG 355
            | :..|:|..|.....|:.:::.||.:|.||.:.|.|||::||:||.:||||.|.||..|.|..|
Zfish  2136 Y-KGGGFVVDLGPDQKNASRLLQYLFDNTWLDVYTRAVFVEFTVYNANVNLFCIVTLIFETTGVG 2199

  Fly   356 GIVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEPH--LLKSVWNKLDLF 418
            ......:|.:..|.::........:.:..|| .:||.:...:..||..:..  ..||.||.|:|.
Zfish  2200 TFQYRSEVQAVHLYQSTGGFHVFVMASEAIY-YIFILYYMVVQGKLMKQQKWAYFKSKWNLLELA 2263

  Fly   419 IFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRV 483
            |.:::...:.:.|.|..|....::..:....| |:.|...:....:....|.||:.:.|::||.:
Zfish  2264 IIILSWSALSVFVKRTILGNRDIEFYQNNKDM-FVSFNETATADAVLGYLIAFLVLLATIKLWHL 2327

  Fly   484 LQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSF 548
            |:......:.|.||..||:.::...:.:.|..:.:..|...:.|...:::..|:::....:|...
Zfish  2328 LRLNPKLHMITSTLQRAWTDISGFIVVMTIMFLAYSIACNLMYGWRLNSYRTLLEAAQTIICLQL 2392

  Fly   549 GFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFE 613
            |.   ....|:......||....|.....:..:::|:|:|:|...|...:.......|..|.  |
Zfish  2393 GI---FNYDEVLDYNPVLGAFLIGSCIIFMTFVVLNLFISVILVAFNEEQLHPTPSEEEEIV--E 2452

  Fly   614 FLVVEFSGVLG 624
            .::::...:||
Zfish  2453 LMLMKVCSLLG 2463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	104/443 (23%)
pkd1l2a	XP_017212723.2	CLECT	40..159	CDD:153057
		Gal_Lectin	174..258	CDD:307994
		PKD	275..346	CDD:214510
		GPS	1298..1343	CDD:321989
		PLAT_polycystin	1406..1525	CDD:238850
		PKD_channel	2025..2437	CDD:332708	102/434 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020