Protein Alignment brv3 and brv1

DIOPT Version :10

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: NP_649116.1
• Gene: brv1 / 40116
• FlyBaseID: FBgn0036874
• Length: 728
• Species: Drosophila melanogaster
• Alignment Length: 736
• Identity: 280/736 - (38%)
• Similarity: 445/736 - (60%)
• Gaps: 22/736 - (2%)

  Fly     4 KKTHWAMFAITVGIIIGCMICIAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDR 68
            ||....:|.:|:.||..|:.||.:|:||:||..||..:||:.:.|.:.|.||..||||.|:|:|.
  Fly     3 KKFSNIIFYLTLIIIAICVACIWMFSGFRHEYGKFNMILVAFLAVTLLQILIFTPIKFTIMSLDA 67

  Fly    69 ALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYG 133
            |.||  .:..|. ..||....:...|.|:.||...|:.||:|.|:||.::|.:|::|..:|::.|
  Fly    68 AFWP--AHQAPE-TPDENANVDTFMDNLRLRLRTLRSELMITERHRNERVNLKYRLITEELWLTG 129

  Fly   134 PYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVYFLNQLFDFIESTLVLAFNSNST 198
            ..||....:.|...|:.||.||.....||..||.|..||..|..:..::.|:.|:|||||.....
  Fly   130 KLFLVYFFMALAFFDELLYFNTEATELLFQCNHGDAFGLLSVGDVPDIYFFVVSSLVLAFTDGKN 194

  Fly   199 ESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLHYSDKYWRIYE 263
            .||...|.|||.:.||||:||||||..:.::||..|.|::..:...|.|||.::.|:||||.||.
  Fly   195 TSGGAPWIHAEGTRLLGVVRLRQLRTESNRLGLSLPVFTERDFSESWTLPYERVPYTDKYWPIYT 259

  Fly   264 PWIP-IKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSA 327
            ||:| :.:.   .|.|||..:|||.:.:|||..||..||:.:...|:|:||||.:.:||..||:|
  Fly   260 PWLPSVSVA---RDNLLMGINHVGHMFNYPESKGYKVLLSDTRHKSLKIIDYLMKKNWLDANTTA 321

  Fly   328 VFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPD--VQVDSAKLLENVDQMPYTGLLALLIYVLVF 390
            :|:||:|||.|.|.|::|||.|||.|:.  .||  .:::|...:|.:.:....|:|.:.::|:.:
  Fly   322 LFMDFSLYNADANTFTVCTLWVEKFPYQ--YPDGHTRIESHTFVEQLREFTKFGMLMVFVFVVTW 384

  Fly   391 IQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDF 455
            :||.:...:|:||:|..||::|.::|..|..::::|.:::.:|::||..|:|.||.|..::|:||
  Fly   385 LQFTKAFFLKVWYDPRQLKTLWVQVDAMIVALSLVVGMIMSVRDNLVQKMIKSVEIAVVVDFLDF 449

  Fly   456 RRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCF 520
            |.|:::..|..:..|..:.:.|:|||:||||::.|:|||:|:.:||.|:..|.:..|||:|....
  Fly   450 REPAQLAYLEDVVTGLAVALVTMRLWKVLQFSATFQLFTKTIAMAWDALLCTFVITVIFIIAIGI 514

  Fly   521 AVVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINV 585
            |.|||||||:|||....|.:|...|::||::..|.|.::|:||:|||||.|.::.||:..:|||:
  Fly   515 ATVTINGNYTSNFRDFPKGIVTVTCFAFGYTNLVYPPDIFYGGEWLGILLYTIMGFVVKYMLINL 579

  Fly   586 FVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVAENVSRK 650
            .||::.|.....|..||.:...||||::||.||::..:....|:...::.|.|..||||:|:.||
  Fly   580 IVSMMRDQMASVKADRDKKVRQRITFWQFLRVEYAHFINYIVKVFHCQKGYQRKNRTVAQNIQRK 644

  Fly   651 LDSMDRQRLMRRRLRQGRHHVS----RPVSAEDALLEYKDRGDKMVNVHYILNIQLTLIRMFLF- 710
            |:|   ..|.||:.:....:..    .|:..:...::|::|.::...:..||:.|:.|:...:|
  Fly   645 LNS---NELKRRKTKISSIYSETIYVMPIDKDLEQMKYRERIERTFTLAAILHTQMELMERLMFG 706

  Fly   711 DEYVEWP---QEQQKQPEAQD 728
            ||....|   ||.::.||.::
  Fly   707 DEEGNLPSLDQEDEQVPETEE 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	Polycystin_dom	171..369	CDD:466668	88/200 (44%)
		PKD_channel	370..595	CDD:462341	87/224 (39%)
brv1	NP_649116.1	Polycystin_dom	167..363	CDD:466668	88/200 (44%)
		PKD_channel	364..591	CDD:462341	87/226 (38%)