Protein Alignment brv3 and PKD1L3

DIOPT Version :10

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: NP_853514.1
• Gene: PKD1L3 / 342372
• HGNCID: 21716
• Length: 1732
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 120/638 - (18%)
• Similarity: 224/638 - (35%)
• Gaps: 176/638 - (27%)

  Fly    42 LVSIVIVLIFQFLIGDPIKFVILSIDRALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRAN 106
            ::||::.::....|..|:|.|..:...:|...|:   ||.:|:  :|::.:|..   .|:.|.::
Human  1188 MISIILSVLQNIFISQPVKVVFFTFLYSLMMSRM---PRLNKE--NEQQTKRIL---ALLAKCSS 1244

  Fly   107 LMLTSRYRN-------------------YKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLY 152
            .:..||.:|                   .|....:|:.. |:.:...:...||..:...::...:
Human  1245 SVPGSRDKNNPVYVAPAINSPTKHPERTLKKKKLFKLTG-DILVQILFLTLLMTAIYSAKNSNRF 1308

  Fly   153 HNTRIITDLFMYNHTDYTGLQEVY------FLNQLF-DFIESTLV-------------------- 190
            :..:.|...|.:..::...||:.|      .|..|: |:.....|
Human  1309 YLHQAIWKTFSHQFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTK 1373

  Fly   191 ---------LAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQ 246
                     |||..|....|.|      :|:..|:...|...:.:|:              |...
Human  1374 TYEKVDEGQLAFCDNGHTCGRP------KSLFPGLHLRRFSYICSPR--------------PMVL 1418

  Fly   247 LPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKV 311
            :|..:||                             :.:.|.|
Human  1419 IPTDELH-----------------------------ERLTSKN---------------------- 1432

  Fly   312 IDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMP 376
                 ||.:..:...|.|       ..:.|.|..:|::.|.   |.|..:          :.|:.
Human  1433 -----ENGFSYIMRGAFF-------TSLRLESFTSLQMSKK---GCVWSI----------ISQVI 1472

  Fly   377 YTGLLALLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRESLVASMM 441
            |    .||:....|||..| |..:.|   .......|.||..|.:::.:::.|.:...||....|
Human  1473 Y----YLLVCYYAFIQGCQ-LKQQKW---RFFTGKRNILDTSIILISFILLGLDMKSISLHKKNM 1529

  Fly   442 KKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAWSAVAS 506
            .:... .:..||.|....:::...|..:||.:.:.|::||.:|:.:...::.:|||..||..|..
Human  1530 ARYRD-DQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVG 1593

  Fly   507 TAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCY 571
            ..:.|:|.|.|:..|...:.|...|::.....|.|..:....|.|.|   .|:|.....||....
Human  1594 FLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQ---EEVFALDPVLGTFLI 1655

  Fly   572 GVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLG 624
            .....::::::||:|||.|  .....|..:..::|  ....:.|:.:.|.:||
Human  1656 LTSVILMVLVVINLFVSAI--LMAFGKERKSLKKE--AALIDTLLQKLSNLLG 1704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	Polycystin_dom	171..369	CDD:466668	33/233 (14%)
		PKD_channel	370..595	CDD:462341	56/224 (25%)
PKD1L3	NP_853514.1	CLECT	33..138	CDD:153057
		GPS	633..672	CDD:470616
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	635..685
		PLAT_polycystin	743..859	CDD:238850
		PKD_channel	1467..1678	CDD:462341	56/234 (24%)
		Channel pore-region	1613..1651		9/40 (23%)