DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brv3 and Pkd2l1

DIOPT Version :10

Sequence 1:NP_001284831.1 Gene:brv3 / 31246 FlyBaseID:FBgn0040333 Length:750 Species:Drosophila melanogaster
Sequence 2:NP_852087.2 Gene:Pkd2l1 / 329064 MGIID:1352448 Length:760 Species:Mus musculus


Alignment Length:629 Identity:143/629 - (22%)
Similarity:268/629 - (42%) Gaps:94/629 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 KMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDY-TGLQEVYFLNQLFDFIE 186
            |....:|.:|..:.:.:..|.......:.|:.|:::::||::..:|. ...|.:..::..:||.:
Mouse    98 KTTLRELVVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDSGVSFQTISSMSDFWDFAQ 162

  Fly   187 STLVLA------FNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSD-----TY 240
            ..|:.:      :|:.|...||..:.:.| ::|||..|||||||.|....:......|     ..
Mouse   163 GPLLDSLYWTKWYNNQSLGRGSHSFIYYE-NLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDV 226

  Fly   241 YMPDW--QLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLAR 303
            |.||.  |||:..  .:...|..:.            ...|....|.|.|.||.. .||...|..
Mouse   227 YSPDKEDQLPFGP--QNGTAWTYHS------------QNELGGSSHWGRLTSYSG-GGYYLDLPG 276

  Fly   304 SAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKL 368
            |...|.:.:..|.|..||...|..|||||::||.::|||.|..|.||....||.:|..|:.:.||
Mouse   277 SRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKL 341

  Fly   369 LENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLWYEPHL-----LKSVWNKLDLFIFMVNVLVVV 428
            :..|:...:. ::...:...|||.:   ..|:...|.||     |.||||.|||.:.:::::.|.
Mouse   342 IRYVNNWDFF-IVGCEVVFCVFIFY---YVVEEILEIHLHRLRYLSSVWNILDLVVILLSIVAVG 402

  Fly   429 LVVLR----ESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASV 489
            ..:.|    ..|:..::::.:..:..||:.|.: ::.:.:..:.:.|    ..:::::.:.|...
Mouse   403 FHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQ-TQYNNMNAVNLFF----AWIKIFKYISFNKT 462

  Fly   490 FKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVV--TINGNYSSNFNKLVK---SMVMCMCYSFG 549
            ....:.|  ||..|......||:.|::.|.:|.:  .:.|....||:..||   :....:...|.
Mouse   463 MTQLSST--LARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFD 525

  Fly   550 FSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEF 614
            ::|      :.:..:.||.:.:....|.:..:|:|:|:::|||.::..|.....::: ::...:|
Mouse   526 YNA------IDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELAGQKD-QLQLSDF 583

  Fly   615 LVVEFSGVLGRFRKLPCWRRNYVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHVSRPVSAED 679
            |...::..|.|.|    .|:..|.:.:.|.:....::...|....: |.|....|.::.      
Mouse   584 LKQSYNKTLLRLR----LRKERVSDVQKVLKGGEPEIQFEDFTSTL-RELGHEEHEITA------ 637

  Fly   680 ALLEYKDRGDKMVNVHYILNIQLTLIRMFLFDEYVEWPQEQQKQ 723
            |...:...||.:::                     |..|||.:|
Mouse   638 AFTRFDQDGDHILD---------------------EEEQEQMRQ 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brv3NP_001284831.1 Polycystin_dom 171..369 CDD:466668 63/210 (30%)
PKD_channel 370..595 CDD:462341 49/238 (21%)
Pkd2l1NP_852087.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
Polycystin_dom 147..342 CDD:466668 63/210 (30%)
PKD_channel 343..567 CDD:462341 49/240 (20%)
EFh 616..654 CDD:415501 8/65 (12%)
Fer4_24 699..732 CDD:436280
Required for homooligomerization. /evidence=ECO:0000250 701..760
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.