Protein Alignment brv3 and Pkd2l1

DIOPT Version :9

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_038964804.1
• Gene: Pkd2l1 / 293937
• RGDID: 1306261
• Length: 763
• Species: Rattus norvegicus
• Alignment Length: 656
• Identity: 152/656 - (23%)
• Similarity: 279/656 - (42%)
• Gaps: 86/656 - (13%)

  Fly   123 KMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTD-YTGLQEVYFLNQLFDFIE 186
            |....:|.:|..:.:.:..|.......:.|:.|:::::||::..:: ....|.:..::..:||.:
  Rat    98 KTTLRELVVYIVFLVDVCLLTYGMTSSSAYYYTKVMSELFLHTPSESAVSFQTISSMSDFWDFAQ 162

  Fly   187 STLVLA------FNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSD-----TY 240
            ..|:.:      :|:.|..|.|..:.:.| ::||||.|||||||.|....:......|     ..
  Rat   163 GPLLDSLYWTKWYNNQSLGSSSHSFIYYE-NLLLGVPRLRQLRVRNDSCVVHEDFREDILNCYDV 226

  Fly   241 YMPDW--QLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAGYVSLLAR 303
            |.||.  |||:..|  :...|..:.            ...|....|.|.|.||.. .||...|..
  Rat   227 YSPDKEDQLPFGPL--NGTAWTYHS------------QNELGGSSHWGRLTSYSG-GGYYLDLPG 276

  Fly   304 SAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKL 368
            |...|.:.:..|.|..||...|..|||||::||.::|||.|..|.||....||.:|..|:.:.||
  Rat   277 SRQASAEALQGLQEGLWLDRGTRVVFIDFSVYNANINLFCILRLVVEFPATGGAIPSWQIRTVKL 341

  Fly   369 LENVDQMPY--TGLLALLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVV 431
            :..|:...:  .|...:....:.:....:.|.::: :....|.||||.|||.:.:::::.|...|
  Rat   342 IRYVNNWDFFIVGCEVIFCIFIFYYVVEEILEIRV-HRFRYLSSVWNILDLVVILLSIVAVGFHV 405

  Fly   432 LR----ESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKL 492
            .|    ..|:..::::.:.....||:.|.: ::.:.:..:.:.|    ..:::::.:.|......
  Rat   406 FRTLEVNRLMGELLQQPDTYPDFEFLAFWQ-TQYNNMNAVNLFF----AWIKIFKYISFNKTMTQ 465

  Fly   493 FTRTLYLAWSAVASTAIAIVIFLIGFCFAVV--TINGNYSSNFNKLVK---SMVMCMCYSFGFSA 552
            .:.|  ||..|......||:.|::.|.:|.:  .:.|....:|:..||   :....:...|.::|
  Rat   466 LSST--LARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVESFSTFVKCIFTQFRIILGDFDYNA 528

  Fly   553 QVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVV 617
                  :.:..:.||.:.:....|.:..:|:|:|:::|||.::..|.....:|: ::...:.|..
  Rat   529 ------IDNANRILGPVYFITYVFFVFFVLLNMFLAIINDTYSEVKEELAGQRD-QLQLSDLLKQ 586

  Fly   618 EFSGVLGRFRKLPCWRRNYVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHVSRPVSAEDALL 682
            .:|..|.|.|    .|:..|.:.:.|.:....::...|....:|.     ..|..|.:|...|..
  Rat   587 SYSKTLQRLR----LRKERVSDVQKVLKGGEPEIQFEDFTNTLRE-----LGHAEREISEVSAAF 642

  Fly   683 EYKDR-GDKMVNVHYILNIQLTLIRMFLFDEYVEWPQEQQKQPEAQDPDPNLGPD--GSPPQDKR 744
            ...|| ||     |.:.......:|..|.:|.:....|.:          |||..  .|||.:.
  Rat   643 TRFDRDGD-----HILDEEDQAQMRQGLEEERMTLSAETE----------NLGRSVGHSPPGEL- 691

  Fly   745 QDEAEA 750
              :|||
  Rat   692 --DAEA 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	110/448 (25%)
Pkd2l1	XP_038964804.1	PKD_channel	147..567	CDD:400395	110/449 (24%)
		Smc	<557..>743	CDD:224117	37/167 (22%)
		Fer4_24	702..735	CDD:407943

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46093
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820