Protein Alignment brv3 and PKD2L2

DIOPT Version :9

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: NP_001287850.1
• Gene: PKD2L2 / 27039
• HGNCID: 9012
• Length: 624
• Species: Homo sapiens
• Alignment Length: 646
• Identity: 146/646 - (22%)
• Similarity: 261/646 - (40%)
• Gaps: 138/646 - (21%)

  Fly   135 YFLCLMCLVLVTRDQT---LYHNTRIITDLFMYNHT---DYTGLQEVYFLNQLFDFIESTLVLAF 193
            ||:.|:.|.::|....   :|:..::::.||:....   :.|..:.:..:...:.|:|..|:...
Human    35 YFIFLINLCILTFGMVNPHMYYLNKVMSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGL 99

  Fly   194 NSNSTESGSPGWAHAEQ-------------SVLLGVMRLRQLRVSNPQVGLGPPKFSD------- 238
            ..:|       |.:.:|             ::||||.|:|||:|.|....:    :|.
Human   100 YWDS-------WYNNQQLYNLKNSSRIYYENILLGVPRVRQLKVRNNTCKV----YSSFQSLMSE 153

  Fly   239 ---TYYMPDWQLPYRKLHYSDKYWR-----IYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELA 295
               .|...:..|....|..:.: ||     ...||                  |.|.|..|.. .
Human   154 CYGKYTSANEDLSNFGLQINTE-WRYSTSNTNSPW------------------HWGFLGVYRN-G 198

  Fly   296 GYVSLLARSAANSM-KVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVP 359
            ||:..|::|.:.:. |.|| |..|.|:|..|..:||||:|||.:||||.|..|..|....|||:.
Human   199 GYIFTLSKSKSETKNKFID-LRLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILT 262

  Fly   360 DVQVDSAKLLENVDQMPY-TGLLALLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMV- 422
            ..|..|.|||..|....| .....:...:.:|:...|.:.....::....||:||.|:|.:.::
Human   263 SWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQEVKKIKEFKSAYFKSIWNWLELLLLLLC 327

  Fly   423 ------NVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLW 481
                  |....|.:.|   |:..::|..|     ::.||...:..|    |....:|.||....|
Human   328 FVAVSFNTYYNVQIFL---LLGQLLKSTE-----KYSDFYFLACWH----IYYNNIIAITIFFAW 380

  Fly   482 -RVLQFASVFKLFTRTLYLAWSAVAST---------AIAIVIFLIGFCFAVV--TINGNYSSNFN 534
             ::.:|.|    |.:|:    |.::||         ..||:.|:|.|.:|.:  .:.|:...:|:
Human   381 IKIFKFIS----FNKTM----SQLSSTLSRCVKDIVGFAIMFFIIFFAYAQLGFLVFGSQVDDFS 437

  Fly   535 KLVKSM-----VMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYF 594
            ....|:     ::...::|....|..|.        ||.:.:....|.:..:|:|:|:::|||.:
Human   438 TFQNSIFAQFRIVLGDFNFAGIQQANPI--------LGPIYFITFIFFVFFVLLNMFLAIINDTY 494

  Fly   595 TVAKTIRDSERENRITFFEFLVVEFSGVLGRFR--KLPCWRRNYVRNGRTVAENVSR------KL 651
            :..|......|.......:.:...:..||.:||  |.........:....:||...|      ::
Human   495 SEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTKGSGDLAEQARREGFDENEI 559

  Fly   652 DSMDRQRLMRRRLRQGRHHVS-----RPVSAED--ALLEYKDRGDKMVNVHYILNIQLTLI 705
            .:.::.:..:.||.:..:.:.     :||:.|:  .|..|....:|  .:||| |::|..:
Human   560 QNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYAVELEK--ELHYI-NLKLNQV 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	115/478 (24%)
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	115/480 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810