DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and Pkd2

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_032887.3	Gene:	Pkd2 / 18764	MGIID:	1099818	Length:	966	Species:	Mus musculus

Alignment Length:	668	Identity:	147/668 - (22%)
Similarity:	270/668 - (40%)	Gaps:	123/668 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIY 132
            |.||..|:          |:|....|:                 :|        .|.:..:|..|
Mouse   196 RGLWGTRL----------MEESNANRE-----------------KY--------LKSVLRELVTY 225

  Fly   133 GPYFLCLMCLVLV-TRDQTLYHNTRIITDLFM---YNHTDYTGLQEVYFLNQLFDFIESTLV--- 190
             .:||.::|::.. .....:|:.||.::.||:   .:.|:.|..:.:..:...:.|.|.:.:
Mouse   226 -LFFLVVLCILTYGMMSSNVYYYTRTLSQLFIDTPVSKTEKTNFKTLSSMEDFWKFTEGSFLDGL 289

  Fly   191 --LAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSDTYYMPDWQLPYRKLH 253
              .|..||.|::.:..:...| ::||||.|||||||.|....: |....|..          |..
Mouse   290 YWKAQTSNHTQADNRSFIFYE-NLLLGVPRLRQLRVRNGSCSI-PQDLRDEI----------KEC 342

  Fly   254 YSDKYWRIYEPWIPI--KMGFEFL---DALLMNFDHVGSLNSYPELAGYVSLLARSAANSMKVID 313
            | |.|....|...|.  :.|..::   :..|....|.|.:.||.. |||...|:|:...:...:.
Mouse   343 Y-DVYSVSSEDRAPFGPRNGTAWMYTSEKELNGSSHWGIIASYSG-AGYYLDLSRTREETAAQLA 405

  Fly   314 YLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYT 378
            .|..|.||...|.|.||||::||.::|||.:..|..|....||:||..|....||:..|....:
Mouse   406 GLRRNFWLDRGTRAAFIDFSVYNANINLFCVVRLLAEFPATGGVVPSWQFQPVKLIRYVTAFDF- 469

  Fly   379 GLLA----LLIYVLVFIQFAQTLAVKLWYEPHLL---KSVWNKLDLFIFMVNVLVVVLVVLRESL 436
             .||    :..:.:::....:.|.:::    |.|   :|.||.||:.|.:::|:.:|:.:.|.|.
Mouse   470 -FLAACEIIFCFFIIYYVVEEILEIRI----HRLSYFRSFWNCLDVVIVVLSVVAMVINIYRMSN 529

  Fly   437 VASMMKKVEGASKMEFIDFRRPS----RMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTL 497
            ...:::.:|  .:..|.:|...:    :.:.::.:.: ||:.|   :|::.:.|.......:.|:
Mouse   530 AEGLLQFLE--DQNSFPNFEHVAYWQIQFNNISAVMV-FLVWI---KLFKFINFNRTMSQLSTTM 588

  Fly   498 YLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFG-FSAQVKPSELFH 561
            ......:....|...|..:.:......:.|....:|:...:    |:...|. ....:..:|:..
Mouse   589 SRCAKDLFGFTIMFSIIFLAYAQLAYLVFGTQVDDFSTFQE----CIFTQFRIILGDINFAEIEE 649

  Fly   562 GGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKT-----------------------IRDS 603
            ..:.||.|.:....|.:..:|:|:|:::|||.::..|:                       ::..
Mouse   650 ANRVLGPLYFTTFVFFMFFILLNMFLAIINDSYSEVKSDLAQQKAEMELSDLIRKGCQKALVKLK 714

  Fly   604 ERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVA--ENVSRKLDSMDRQRLMRRRLRQ 666
            .:.|.:......:.:..|.| .|.:|   |::....|.|.|  |.:..|.|....|.|..|..:|
Mouse   715 LKRNTVDAISESLRQGGGKL-NFDEL---RQDLKGKGHTDAEIEAIFTKYDQDGDQELTEREHQQ 775

  Fly   667 GRHHVSRPVSAEDALLEY 684
            .|..:.:  ..||..||:
Mouse   776 MRDDLEK--EREDLDLEH 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	105/446 (24%)
Pkd2	NP_032887.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..179
		PKD_channel	265..685	CDD:285288	105/449 (23%)
		Selectivity filter. /evidence=ECO:0000250\|UniProtKB:Q13563	639..641		0/1 (0%)
		EFh	730..776	CDD:298682	14/49 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..828		9/30 (30%)
		Linker. /evidence=ECO:0000250\|UniProtKB:Q13563	801..820
		Important for interaction with PACS1 and PACS2. /evidence=ECO:0000250\|UniProtKB:Q13563	808..819
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	914..966
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810