Protein Alignment brv3 and Pkd1l1

DIOPT Version :10

• Sequence 1: NP_001284831.1
• Gene: brv3 / 31246
• FlyBaseID: FBgn0040333
• Length: 750
• Species: Drosophila melanogaster
• Sequence 2: XP_036013024.1
• Gene: Pkd1l1 / 171395
• MGIID: 2156538
• Length: 2551
• Species: Mus musculus
• Alignment Length: 678
• Identity: 150/678 - (22%)
• Similarity: 246/678 - (36%)
• Gaps: 151/678 - (22%)

  Fly     8 WAMFAITVGIIIGC-------MICIA--VFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVI 63
            |.::.:.:.::. |       |||:|  |||..:..|.||            |...:.|..|.:.
Mouse  1862 WWLYLLLLSLVC-CAFITQPLMICLAALVFAWKRKHDSKF------------FTESLQDATKGLD 1913

  Fly    64 LSID-----RALWPPRIYIPPRCDKDEMDEKE------ERRDFLKQRLINKRANLMLT-SRYRNY 116
            |.::     |....|..|.|     |..:|.|      :|...|:......:|.|.:| .|.|..
Mouse  1914 LELEEHSRTRVPLSPISYSP-----DTAEEAERVLATRQRERHLRWAQTPSKAKLRVTGERLRRE 1973

  Fly   117 K-----LNDQYKMIAHDLFIYGPYFLCLMCLVLVTR----DQTLYHNTRIITDLF--MYNHTDYT 170
            .     |.|   |..|.:      .|.|:..:...|    :.:|.|   .|...|  ..||:
Mouse  1974 SIMQAALRD---MTTHSI------MLLLLLFIAYGRFCPGEISLNH---AIRKAFTRKANHS--- 2023

  Fly   171 GLQEVYFLNQLFDFIESTLVLAFNSNSTES----GSPGWAHAEQSVLLGVMRLRQLRVSNPQVGL 231
             |.::......:|:..|||:.......|.:    ..|| |...|..|:|...::.|::|......
Mouse  2024 -LGDLSSTEDWWDWTLSTLLDELYPERTSARAWGAQPG-ALGGQCHLIGPPVVKLLKISAGTACT 2086

  Fly   232 GPPKFSDTYYMPDWQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNFDHVGSLNSYPELAG 296
            .|..||:   :.:..||   :|.:|                  ||....|....|     ||..|
Mouse  2087 PPRPFSE---LVEDVLP---MHSND------------------LDLENQNVSPGG-----PETCG 2122

  Fly   297 -----YVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGG 356
                 |:..|.::...:...:..|..:.|:..:|.|:.:.|||||....||:...|..|..|.||
Mouse  2123 VKKESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGG 2187

  Fly   357 IVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQFAQTLAVKLW-YEPHLLKSVWNK----LD 416
            :||...|:|.::..:...:.|..:|:.|:::::.:..   |..:|| .....:.|.|.|    |:
Mouse  2188 LVPSFLVESFRIFYSDSALKYLLMLSELLFLVLNVIH---LCFQLWGMTTKGILSYWRKPRHWLE 2249

  Fly   417 LFIFMVNVLVVVLVVLRE--SLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLR 479
            |  .||.|.:........  :|..::..:.........:|.......||......|.|:.:..|:
Mouse  2250 L--SMVGVAIAYYAASGHLTTLAVNITDQFHKGLYQRLVDIGLMVSWHQRARCLQGILLFLWMLK 2312

  Fly   480 LWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCM 544
            ...:|...|....|        |||....:..|: |:|    .:.:..:|.|.:..|....:
Mouse  2313 YVHLLSSLSTMTPF--------SAVTCFPLFRVL-LVG----ALLLAAHYHSRWFLLFTGTL--- 2361

  Fly   545 CYSFGFSAQVKPSEL--FHG----GKWLGIL--------CYGVLAFVIIVLLINVFVSLINDYFT 595
              |.|.||:..|..|  |.|    ..|...|        ||....|:::..|  .|..|...:.|
Mouse  2362 --SHGTSAEAFPGLLLQFPGRSKKDSWHNCLKSDHGVMRCYYGTLFLLLATL--GFRMLRATFLT 2422

  Fly   596 VAKTIRDSERENRITFFEFLVVEFSGVL 623
            |.:..:.|.|:..:|..:..|..:..||
Mouse  2423 VFQNRKSSHRKPLVTLKDIAVYTWHKVL 2450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	Polycystin_dom	171..369	CDD:466668	50/206 (24%)
		PKD_channel	370..595	CDD:462341	49/245 (20%)
Pkd1l1	XP_036013024.1	PCC	<167..622	CDD:188093
		REJ	<835..976	CDD:366875
		GPS	1387..1425	CDD:470616
		PLAT	1493..1611	CDD:412108
		Polycystin_dom	2023..2198	CDD:466668	50/208 (24%)