DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment brv3 and PKD1L2

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_443124.3	Gene:	PKD1L2 / 114780	HGNCID:	21715	Length:	2459	Species:	Homo sapiens

Alignment Length:	728	Identity:	162/728 - (22%)
Similarity:	264/728 - (36%)	Gaps:	156/728 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAMFAITVGIIIGCMICIAVFA---GFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDRA 69
            |.:.|.|.|:       .|.|.   |..:........|:|:.:..:....:..|:|.:..:...|
Human  1826 WLLVAATSGV-------AAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVLGFAAFFA 1883

  Fly    70 LWPPRIYIPPRCDKDEMD--------------------EKEERRDFLKQRL---INKRANLMLTS 111
            |...|:       .||.|                    .:...||..:..|   |.|    |.|:
Human  1884 LVLKRV-------DDEEDTVAPLPGHLLGPDPYALFRARRNSSRDVYQPPLTAAIEK----MKTT 1937

  Fly   112 RYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLV-TRDQTLYHNTRIITDLFMYNHTDYTGLQEV 175
            ..:..|   .:.:|...|...|  ||.::.||.. .||.:.||..|.:      .|:...|...|
Human  1938 HLKEQK---AFALIREILAYLG--FLWMLLLVAYGQRDPSAYHLNRHL------QHSFTRGFSGV 1991

  Fly   176 YFLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRV--------SNPQV--- 229
            ....:.|.:..:|||     ::.....||:.....|.|:|..::||:||        ..||.
Human  1992 LGFREFFKWANTTLV-----SNLYGHPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYLN 2051

  Fly   230 GLGPPKFSDTYYMPD------------WQLPYRKLHYSDKYWRIYEPWIPIKMGFEFLDALLMNF 282
            |...|...|...|.|            ||      :.|....:.|..|
Human  2052 GCRAPYSLDAEDMADYGEGWNATTLSEWQ------YQSQDQRQGYPIW----------------- 2093

  Fly   283 DHVGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTL 347
               |.|..| ...|||..|.....::.:::.||.:|.||...|.|||::.|:||.:||||.|.||
Human  2094 ---GKLTVY-RGGGYVVPLGTDRQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTL 2154

  Fly   348 RVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQF----AQTLAVKLWYEPHLL 408
            .:|.:..|.......:.|.:|....|......:.|.|||.|..:.:    .:.::.:.|   ...
Human  2155 TLETSALGTFFTHAALQSLRLYPFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETW---GYF 2216

  Fly   409 KSVWNKLDLFIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLI 473
            .|.||.|:|.|.:.:...:.:.|.|..|....:::... .:.|.|.|...:.........|.||:
Human  2217 CSKWNLLELAIILASWSALAVFVKRAVLAERDLQRCRN-HREEGISFSETAAADAALGYIIAFLV 2280

  Fly   474 CITTLRLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTING----NYSSNFN 534
            .::|::||.:|:......:.|..|..||..::...|.|:..|:.:..|...|.|    :|.:.|:
Human  2281 LLSTVKLWHLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFD 2345

  Fly   535 KLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKT 599
             ..::||......|.:...:..|.:.  |.:|...|...:.||:    :|:|:|:|...|:..:.
Human  2346 -AAETMVSLQLGIFNYEEVLDYSPVL--GSFLIGSCIVFMTFVV----LNLFISVILVAFSEEQK 2403

  Fly   600 IRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVAENVSRKLDSMDRQRLMRRRL 664
            ......|..|.  :.|:::....||                      :..|.:.....|.....|
Human  2404 YYQLSEEGEIV--DLLLMKILSFLG----------------------IKSKREEPGSSREQPGSL 2444

  Fly   665 RQGRHHVSRPVSA 677
            .|.||  |||..|
Human  2445 SQTRH--SRPAQA 2455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	108/455 (24%)
PKD1L2	NP_443124.3	CLECT	28..153	CDD:214480
		Gal_Lectin	170..251	CDD:307994
		GPS	1280..1319	CDD:197639
		PLAT_polycystin	1390..1509	CDD:238850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1625..1649
		PKD_channel	1987..2400	CDD:332708	109/455 (24%)
		Channel pore-region	2340..2362		5/22 (23%)
		Interaction with GNAS and GNAI1. /evidence=ECO:0000269\|PubMed:15203210	2379..2459		22/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2431..2459		9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020