DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and PKDREJ

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	NP_006062.1	Gene:	PKDREJ / 10343	HGNCID:	9015	Length:	2253	Species:	Homo sapiens

Alignment Length:	648	Identity:	143/648 - (22%)
Similarity:	256/648 - (39%)	Gaps:	149/648 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LIGDPIKFVILSIDRA---------LWPPRI-YIPPRCD-----KDEMDE--------------- 88
            |:..|.|.::||..|.         .|..:. |...|.|     .:||..
Human  1623 LLVQPSKIILLSGFRTNKPKYCKNLSWSTKYKYTEIRLDGMRMHPEEMQRIHDQIVRIRGTRMYQ 1687

  Fly    89 ---KEERRDFLKQRLINKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQT 150
               ::|.|.|.:::.|.:||.|.|:            .::.|.:|:    .|.|:.:||:.....
Human  1688 PLTEDEIRIFKRKKRIKRRALLFLS------------YILTHFIFL----ALLLILIVLLRHTDC 1736

  Fly   151 LYHNTRIITDLFMYNHTDYTGLQEVY-FLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLL 214
            .|:| :.|.|.|..:....|.|:::| :||.:.      |.|..|..     :|.:.....|.:|
Human  1737 FYYN-QFIRDRFSMDLATVTKLEDIYRWLNSVL------LPLLHNDL-----NPTFLPESSSKIL 1789

  Fly   215 GVMRLRQLRV-SNPQVGLGPPKFSDTYYMPDWQLPYRKLHYSDKY-------------WR----- 260
            |:..:||:|. |:.::.|...||......       |::|...||             |.
Human  1790 GLPLMRQVRAKSSEKMCLPAEKFVQNSIR-------REIHCHPKYGIDPEDTKNYSGFWNEVDKQ 1847

  Fly   261 ---------IYEP----WIPIKMGFEFLDALLMNFDHVG-SLNSYPELAGYVSLLARSAANSMKV 311
                     .|:|    |:....|      ||..:...| :|..:||         :...||...
Human  1848 AIDESTNGFTYKPQGTQWLYYSYG------LLHTYGSGGYALYFFPE---------QQRFNSTLR 1897

  Fly   312 IDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMP 376
            :..|.|::||...|.||.::.|.:|.|:|||...::..|.:..|.:...:.:.|..|.: .|:..
Human  1898 LKELQESNWLDEKTWAVVLELTTFNPDINLFCSISVIFEVSQLGVVNTSISLHSFSLAD-FDRKA 1961

  Fly   377 YTGL---LALLIYVLVFIQFAQTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVV--LRESL 436
            ...:   :|:||:.|.::  .....:.:......::||:|.|:   |.:..:..||:|  ||:..
Human  1962 SAEIYLYVAILIFFLAYV--VDEGCIIMQERASYVRSVYNLLN---FALKCIFTVLIVLFLRKHF 2021

  Fly   437 VASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRTLYLAW 501
            :|:.:.:...::..:||.|...|::..:..|.:|||:.:|.|:..|..:|....:|..|.:..|.
Human  2022 LATGIIRFYLSNPEDFIPFHAVSQVDHIMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAAL 2086

  Fly   502 SAVASTAIAI-VIFLIGFCFAVVTINGNYSSNFNKLVKS--MVMCMCYSFGFSAQVKPSELFHGG 563
            ..:...|..: |.|.:...|..: :.|.:..|::.|:.|  .|...|.|...:.:      |...
Human  2087 PGICHMAFVVSVYFFVYMAFGYL-VFGQHEWNYSNLIHSTQTVFSYCVSAFQNTE------FSNN 2144

  Fly   564 KWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRI-----------TFFEFL 615
            :.||:|.......|:|.:|||:|.::|...:...|.....|..:.:           |.|.||
Human  2145 RILGVLFLSSFMLVMICVLINLFQAVILSAYEEMKQPVYEEPSDEVEAMTYLCRKLRTMFSFL 2207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	106/466 (23%)
PKDREJ	NP_006062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..177
		REJ	243..711	CDD:280229
		GPS	1100..1166	CDD:295363
		PLAT_polycystin	1231..1346	CDD:238850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1494..1562
		PKD_channel	1748..2178	CDD:285288	106/475 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920