DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and pkd1l1

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_021325910.1	Gene:	pkd1l1 / 101887130	-ID:	-	Length:	2572	Species:	Danio rerio

Alignment Length:	902	Identity:	159/902 - (17%)
Similarity:	278/902 - (30%)	Gaps:	328/902 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 THWAMFAITVGIIIGCMICIAVFAGFQH------------------------EDVKFKTMLVSIV 46
            |:|:.:..:..:::..|..:.:|..|.|                        |..|.|...|..|
Zfish  1705 TYWSYWMHSFRLLVYVMYDLGLFCSFLHNIGTIGKYEQEGGDKNTKSSSVSGEQYKLKVSDVCSV 1769

  Fly    47 IVLIFQFLIGDPIKFVILSIDRALWPPRIYIPPRCDKDEMD----------EKEERRDFLKQRL- 100
            ......||:.:......||     |..   :...|.|:..|          :.::..|.:.:.:
Zfish  1770 EEHHNAFLMNNRASESCLS-----WNS---VSCSCKKEYKDCITSDSVSASKLQDNTDTILEIVD 1826

  Fly   101 -----INKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGP------------YFLCL-MCLVLVTR 147
                 :|||::.....:..|.|.:...:::.:..|..|.            :.||: :||..||.
Zfish  1827 DSISDVNKRSHGKRKWKKSNCKSHFSAEVLKNQQFCDGTIQSLGAWCRYLGWTLCVSLCLTCVTI 1891

  Fly   148 DQTLYHN------TRIITDLF------------------MYNHTDYTGLQEVYFLNQLFDFIEST 188
            ..:|..|      .:..|.|:                  |.||.|.:....||           .
Zfish  1892 TGSLGLNFIHSRFNKTETQLWAHSVFFSLICGGFVLHPAMVNHLDPSLRIAVY-----------G 1945

  Fly   189 LVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFSD--------------- 238
            .:|.|:..|         |....||....|.|.||:      :.||...|
Zfish  1946 FILIFDQQS---------HHWSFVLADRQRARFLRL------VRPPNSKDLKLVRGQIKKQTLLY 1995

  Fly   239 -------------------TYYMPDWQLPYR-----KLHYS-------------DKYWRIYEPWI 266
                               .|...|....||     |.|::             |.:|.    |.
Zfish  1996 KTTRDLMLHLIMLWMIIFVAYGKSDSDSKYRLNQAIKTHFTKSLQNSFHSIQKHDDWWN----WT 2056

  Fly   267 PIKM---------------------GFEFLDA------------------LLMN-----FDH--- 284
            ...:                     .|..:.:                  ||.|     ||:
Zfish  2057 TTSLLEKLYNNADNQDERQEHDTGAAFSLIGSPVITKIKSTHNSSCQILNLLSNDKNNCFDNQSA 2121

  Fly   285 -------VGSLNSYPELAGYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLF 342
                   .|.|..|.....||| |.::..|:...:..|.|..|:|..|..|.:.|.|||...|||
Zfish  2122 TKKLAPFCGKLGCYKGERVYVS-LGKTRLNAFTSVKRLLETGWMTPFTQIVILQFVLYNGPSNLF 2185

  Fly   343 SICTLRVEKTPFGGIVPDVQVDSAKLLENVDQMPYTGLL--------ALLIYVLVFIQFAQTLAV 399
            :..|:.||||..|.::|...|.|.:|......:.|:.::        :||:|:...
Zfish  2186 TSVTILVEKTSTGALLPSASVQSTRLYYFPTALDYSVMICEVTVIICSLLLYICSM--------- 2241

  Fly   400 KLWYEPHLLKSV--WNKLDLFIFMVNVLVVV----LVVLRE----------SLVASMMKKVEGAS 448
               |:..|...|  :.|.:.|..:|::..:.    |..|:.          .::.::.||.. ..
Zfish  2242 ---YKLQLKTEVIDFLKKEDFKLLVDLSSIFFCEQLYFLKHQTTYNNFFSPKIITNITKKAV-TK 2302

  Fly   449 KMEFIDFRRPSRMHQLTTITIGFLI------CITTLRLWRVLQFASV-FKL-FTRTLYLAWSAVA 505
            |:.....  |....||:...:|.::      |:..|||.:.:..|.| :|| |:..::|     .
Zfish  2303 KLPICQL--PIYHLQLSQSLLGIVVNLLLLKCLHLLRLNKTVAAAVVTWKLIFSNLIWL-----L 2360

  Fly   506 STAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFHGGKWLGILC 570
            :..:.|.:.|...|..::     :|..|..|.:.:.....|......|......|.||
Zfish  2361 APGVIIALALSNLCNLIL-----HSVPFTSLTRLLFTRFLYIIDIHLQSHVPPTFFGG------- 2413

  Fly   571 YGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLGRFRKLPCWRRN 635
               |.|..::.:..|.::.:..:...||. :..:|::.::.||.                   .:
Zfish  2414 ---LVFFTMIPVKAVLIATLAIFVKQAKN-KSKKRKDLLSVFEL-------------------TS 2455

  Fly   636 YVRNGRTVAENVSRKLDSMDRQRLMRRRLRQGRHHVSRPVSAEDALLEYKDRGDKMV 692
            ||:...|:.:...:..|..|.....                   .|.|::|..|:::
Zfish  2456 YVKALFTIKKASHKSTDHQDHANSF-------------------YLAEFEDLMDELI 2493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	104/562 (19%)
pkd1l1	XP_021325910.1	PCC	<150..>300	CDD:188093
		PCC	<228..540	CDD:188093
		PLAT	1465..1579	CDD:320707
		PKD_channel	2042..>2237	CDD:332708	43/199 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010