DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and pkd1l2

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_031756633.1	Gene:	pkd1l2 / 100486136	XenbaseID:	XB-GENE-968335	Length:	2458	Species:	Xenopus tropicalis

Alignment Length:	695	Identity:	150/695 - (21%)
Similarity:	263/695 - (37%)	Gaps:	125/695 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAMFAITVGIIIGCMICIAVFAGFQHEDVKFKTMLVSIVIVLIFQFLIGDPIKFVILSIDRALWP 72
            |.:.|.|.|:.....:...:..|   :|...| .|:|:.|.......|..|:|.:..:...||..
Frog  1828 WLLVAATSGVSAFFTMLYGLHYG---KDSSIK-WLISMAISFFESLFITQPLKVLGFAAFFALVL 1888

  Fly    73 PRIYIPPRCDKDEMDEKEE-------------------RRDFLKQRLINKRANLM-------LTS 111
            .::         |.:::||                   |||          :|:.       :|.
Frog  1889 KKV---------EPEDEEETTINGNLSTPGDPNPLLGSRRD----------SNIYQPPPPTDITK 1934

  Fly   112 RYRNYKLNDQYKMIAHDLFIYGPYFLCLMCLVLVTRDQTLYHNTRIITDLFMYNHTDYTGLQEVY 176
            ...||....:...:..::..|..:...|:.:....||...|:..:.|...|    ||  |.:::.
Frog  1935 MKNNYMKEQKVFALIREILAYLGFLWMLLLVAYGQRDPNSYYLNKHIESSF----TD--GFEDLC 1993

  Fly   177 FLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGVMRLRQLRVSNPQVGLGPPKFS--DT 239
            ...:.|.:..:||:     |:.....||:.....|.|:|..|:||:|:......:.....|  |.
Frog  1994 SYQEFFTWANTTLI-----NNLYGSHPGFITDGNSKLVGGARMRQIRIKKDSCPVASVLQSTIDN 2053

  Fly   240 YYMPDWQLPYRKLHYSDKYWR---------IYEPWIPIKMGFEFLDALLMNFDHVGSLNSYP--- 292
            ...| :.|...::.:.|..|.         :..||.               :.:...|..:|
Frog  2054 CRAP-YSLDAEEMGHYDGSWNFSAITNATDVNSPWY---------------YQNHSKLRGHPTWG 2102

  Fly   293 ELA-----GYVSLLARSAANSMKVIDYLSENHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKT 352
            :||     |||:.|......:.:|:..|..|.||...|.|||::||:||.:||||.|..|..|..
Frog  2103 KLATYRGGGYVADLGNERKYAHRVLQDLFSNIWLDSYTRAVFVEFTVYNANVNLFCIVKLMFETN 2167

  Fly   353 PFGGIVPDVQVDSAKLLENVDQMPYTGLLALLIYVLVFIQF----AQTLAVKLWYEPHLLKSVWN 413
            ..|.......:.|.:|....|.:....:.|.:||.|..|.:    .:.:..:.|   ...:|.||
Frog  2168 ALGTFFTRANLQSVRLYPFTDGLHIFVVAAEVIYFLFVIYYMVVQGKRMKAEKW---GYFRSKWN 2229

  Fly   414 KLDLFIFMVNVLVVVLVVLRESLVASMMKKVEGASKMEFIDFRRPSRMHQLTTITIGFLICITTL 478
            .|:|.:.:::...:.:.|.|..|....::..: ..|.||:.|...:.........|.||:.::|:
Frog  2230 LLELALIIISWSALSVYVKRTILGTRDLRYYQ-EHKNEFVSFNETAAADAALGYLIAFLVLLSTI 2293

  Fly   479 RLWRVLQFASVFKLFTRTLYLAWSAVASTAIAIVIFLIGFCFAVVTING----NYSSNFNKLVKS 539
            :||.:|:......:.|.||..||..::.....|||..:.:..|...|.|    :|.:.|:. .|:
Frog  2294 KLWHLLRLNPKLNMITATLRRAWGDISGFITVIVIMFLAYSIACNLIFGWKLNSYKTVFDS-AKT 2357

  Fly   540 MVMCMCYSFGFSAQVKPSELFHGGKWLGILCYGVLAFVIIVLLINVFVSLINDYFTVAKTIRDSE 604
            ||......|.:      .|:......||....|.....:..:::|:|:|:|...|:..:....:.
Frog  2358 MVSLQLGIFNY------EEVLDYNPVLGSFLVGSCIIFMTFVVLNLFISVILVAFSEEQKHHQAS 2416

  Fly   605 RENRITFFEFLVVEFSGVLGRFRKLPCWRRNYVRNGRTVAENVSR 649
            .|..|.  |.|:.:....||...|         :...:..||||:
Frog  2417 DEEEIV--ELLLWKICSFLGLRHK---------KEEASAMENVSK 2450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	104/451 (23%)
pkd1l2	XP_031756633.1	CLECT	22..147	CDD:214480
		Gal_Lectin	163..243	CDD:396628
		REJ	<615..890	CDD:366875
		GPS	1276..1314	CDD:396408
		PLAT_polycystin	1385..1504	CDD:238850
		PKD_channel	1988..2408	CDD:400395	105/451 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020