DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brv3 and Pkd1l3

DIOPT Version :9

Sequence 1:	NP_001284831.1	Gene:	brv3 / 31246	FlyBaseID:	FBgn0040333	Length:	750	Species:	Drosophila melanogaster
Sequence 2:	XP_038954217.1	Gene:	Pkd1l3 / 100362565	RGDID:	2324490	Length:	2183	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	151/686 - (22%)
Similarity:	269/686 - (39%)	Gaps:	148/686 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LVSIVIVLIFQFLIGDPIKFVILSIDRALWPPRIYIPPRCDKDEMDEKEERRDFLKQRLI----- 101
            ::|:::.::....|..|||.:.|::..:|....:   |...||    ||..    .:|::
  Rat  1556 VISMMLSVLQDIFICQPIKVIFLTLLFSLMANHM---PWLTKD----KEHH----ARRIVALWAK 1609

  Fly   102 --------NKRANLMLTSRYRNYKLNDQYKMIAHDLFIYGP-------YFLCLMCLVLVTRDQTL 151
                    ..:.|.:.|:...|:......|:....||:...       :...||..|...:|.:.
  Rat  1610 CPSSAPGLRDKNNPIYTAPAMNHLDRRTKKVWRKRLFLLTAGSLVQILFLTLLMTTVYSAKDSSR 1674

  Fly   152 YHNTRIITDLFMYNHTDYTGLQEVYFLNQLFDFIESTLVLAFNSNSTESGSPGWAHAEQSVLLGV 216
            :...|.:...|.:      |..|:..:...:.:...||:     .:......|:.....|.|||.
  Rat  1675 FFLHRAVWKRFSH------GFSEIKAVEDFYPWANRTLL-----PNLYGDYRGFITDGNSFLLGN 1728

  Fly   217 MRLRQLRVSNPQVGLGPPKFSDTY---------------------YMPDWQLPYRKLHYSDKYWR 260
            :.|||:|:.|           ||:                     |...|..|...:..:|..|.
  Rat  1729 VLLRQIRIPN-----------DTHSPVSLHEHMNSYPQHQEDRENYGAGWVPPDTNITKADSIWH 1782

  Fly   261 IYEPWIPIKMGFEFLDALLMNFDHVGSLNSYP---EL-----AGYVSLLARSAANSMKVIDYLSE 317
            ...|                     .||..||   |:     .|||..|.|:.:.:.:|:.:|.:
  Rat  1783 YQSP---------------------ESLGGYPIQGEVTTYSGGGYVVRLGRNHSAATRVLQHLEQ 1826

  Fly   318 NHWLTLNTSAVFIDFTLYNVDVNLFSICTLRVEKTPFGGIVPDVQVDSAKLLEN--------VDQ 374
            .|||...|.|:|::||::|.:|||..:.||.:|.:..|.....:::||...|::        :.|
  Rat  1827 RHWLDHYTKALFVEFTVFNANVNLLCMVTLILESSGVGTFFTSLRLDSLTSLQSSERGFAWIISQ 1891

  Fly   375 MPYTGLLALLIYVLVFIQFA----QTLAVKLWYEPHLLKSVWNKLDLFIFMVNVLVVVLVVLRES 435
            :.|    .||:....|:|..    |.||        ......|.||..|.:.:..::.|.:...|
  Rat  1892 VAY----YLLVCYYAFVQGCRLKRQGLA--------FFTRRRNILDTSIILTSFSILGLNMQSLS 1944

  Fly   436 LVASMMKKV----EGASKMEFIDFRRPSRMHQLTTITIGFLICITTLRLWRVLQFASVFKLFTRT 496
            |:.:.|::.    :|     ||.|....|::.:.|..:|||:...|:|:|.:|:..:..::..:|
  Rat  1945 LLHTNMQQYRRDPDG-----FISFSEALRVNSVATHLMGFLLLFATVRVWDLLRHHARLQVINKT 2004

  Fly   497 LYLAWSAVASTAIAIVIFLIGFCFAVVTINGNYSSNFNKLVKSMVMCMCYSFGFSAQVKPSELFH 561
            |..||..|....:.|:|.|..:......:.|...|::.....|:|..:....|..   |..|:..
  Rat  2005 LTKAWDEVLGFIMIIMILLSSYAMTFNLLFGWSISDYQSFFSSVVTVVGLLVGIP---KHKEVVA 2066

  Fly   562 GGKWLGILCYGVLAFVII--VLLINVFVSLINDYFTVAKTIRDSERENRITFFEFLVVEFSGVLG 624
            ....||  .:.||:.:|:  :::||:|||.|...|  .|..:..|:|..:|  :.|:.:.|.:||
  Rat  2067 LSPVLG--SFLVLSNIILMGLVIINLFVSAILIVF--GKERKACEKEATLT--DMLLQKLSSLLG 2125

  Fly   625 -RFRKLPCWRRNYVRNGRTVAENVSRKLDSMDRQRL 659
             |..:.|...::....|.:.....|.|..|.|.:.|
  Rat  2126 IRQHQKPASEKHADSTGSSNLRERSSKSMSSDAEVL 2161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brv3	NP_001284831.1	PKD_channel	170..595	CDD:285288	109/471 (23%)
Pkd1l3	XP_038954217.1	CLECT	37..144	CDD:153057
		Herpes_BLLF1	<215..601	CDD:282904
		GPS	1002..1040	CDD:396408
		PLAT_polycystin	1111..1230	CDD:238850
		PKD_channel	1688..2096	CDD:400395	108/466 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1276906at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020