DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Seipin and bscl2

DIOPT Version :9

Sequence 1:	NP_570012.1	Gene:	Seipin / 31245	FlyBaseID:	FBgn0040336	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001032473.1	Gene:	bscl2 / 567403	ZFINID:	ZDB-GENE-051113-140	Length:	350	Species:	Danio rerio

Alignment Length:	327	Identity:	117/327 - (35%)
Similarity:	186/327 - (56%)	Gaps:	27/327 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RELVLRLGLIAFAVVLIIWLAVFMYAAFYYVYMPAISHTRPVHMQFKTCLETSTP--CTFPHAHV 111
            |..:||..::...:||::|:::|:|.:|||.|||::|.:.|||..::|..|.|..  |:||.|:|
Zfish    24 RRTLLRAAILLCVLVLLLWVSIFLYGSFYYSYMPSVSFSTPVHYYYRTDCEASDAVLCSFPMANV 88

  Fly   112 SLTK--KQQLLMVGQAYKVIVNIDMPESPQNLELGMFMVCAEMRDYDSMLRGHSCRSAMMRYRSP 174
            ||.|  :.|::|.||||::.:.::|||||.|.:|||.||.......|..:.....||.|:.|||.
Zfish    89 SLLKNGRDQVMMSGQAYRISLELEMPESPVNEQLGMLMVKMSCYSNDGTVVHSVARSTMLHYRSN 153

  Fly   175 LIRMISTWVLSPLYVLGWKEEFQQVPVEIFSRYLEERQHPITDVYVEIQSQKIQFYTVTLHIVAD 239
            |::.:||.:.|||.:.|..|:.|.|.||:|.....:..||.....:||||:::|.|:..|.|.|.
Zfish   154 LLQTLSTLLFSPLLLSGVSEQKQLVEVELFPDLKLDIYHPAVGAVIEIQSRRVQIYSAQLRIHAY 218

  Fly   240 FTGLRYIMFNWPVLSAIVAISTNLFFILVVFLLSW--YHWSDAKWLHSVQIKY-----ARLTKSL 297
            |||:|::::|:||:||||.:::|..|:.|:.|.|:  :.|........|::|.     .||.:..
Zfish   219 FTGVRFLLYNFPVMSAIVGVASNFTFLSVIVLFSYLQFIWGGLYPPEQVRVKVMIGDSTRLQQRR 283

  Fly   298 EPG--VIHSKASSL-----RDDDDDLVAYSD-----KSDIADVGG-DTLSDVDADDLVLVKKSRS 349
            |..  .:||.||:.     ||..:.|   ||     |..:.:.|. ||.|.:..:||...::..:
Zfish   284 EEARKRMHSSASTPVMTYGRDGSELL---SDPLQHPKQTVRNKGDLDTPSVIGTEDLNNQQEDET 345

  Fly   350 GK 351
            ||
Zfish   346 GK 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Seipin	NP_570012.1	Seipin	63..262	CDD:284243	85/202 (42%)
bscl2	NP_001032473.1	Seipin	44..241	CDD:284243	82/196 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575175
Domainoid	1	1.000	171	1.000	Domainoid score	I3694
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	188	1.000	Inparanoid score	I3895
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1390748at2759
OrthoFinder	1	1.000	-	-		FOG0004864
OrthoInspector	1	1.000	-	-		otm25774
orthoMCL	1	0.900	-	-		OOG6_104060
Panther	1	1.100	-	-	LDO	PTHR21212
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R150
SonicParanoid	1	1.000	-	-		X4543
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.930