Protein Alignment Tsp3A and CD81

DIOPT Version :10

• Sequence 1: NP_525054.2
• Gene: Tsp3A / 31244
• FlyBaseID: FBgn0040334
• Length: 304
• Species: Drosophila melanogaster
• Sequence 2: XP_054226604.1
• Gene: CD81 / 975
• HGNCID: 1701
• Length: 335
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 58/245 - (23%)
• Similarity: 96/245 - (39%)
• Gaps: 50/245 - (20%)

  Fly    56 LFGGLLLGIGVYAFRDKWEDAN------GSVRLENFYDVFLNISLVMILAGTVIFLVSFSGCVGA 114
            |.||::||:.::...|. :..|      |.....|.:.|.:   .::|..|.|:..|.|.||.||
Human   122 LAGGVILGVALWLRHDP-QTTNLLYLELGDKPAPNTFYVGI---YILIAVGAVMMFVGFLGCYGA 182

  Fly   115 LRENTFLLKFYSMCLLLFFLLEMAIAIVCFVCPQYMNTFLEKQFTHKIIHSYRDDPDLQN---FI 176
            ::|:..||..:..||::.|..|:|..|..||....:...: |||..:.:.....|.|..|   .:
Human   183 IQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDV-KQFYDQALQQAVVDDDANNAKAVV 246

  Fly   177 DFAQQEFKCCGLSNSGYQDWSKNEYFNCSSPSVEKCGVPYSCCINATDISSGLVNIMCGYGVQNA 241
            ....:...|||.|.           ....:.||.|    .:.|.:.::|.|.|....|...:.:.
Human   247 KTFHETLDCCGSST-----------LTALTTSVLK----NNLCPSGSNIISNLFKEDCHQKIDDL 296

  Fly   242 PVPEATKLIWTSGCIEIVRVWAEHNLYVIAGNALGIALIQLLVIYLAKTL 291
                      .||           .||:|...|:.:|:|.:..:.|:..|
Human   297 ----------FSG-----------KLYLIGIAAIVVAVIMIFEMILSMVL 325

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp3A	NP_525054.2	Tetraspanin	43..>187	CDD:459767	37/139 (27%)
		penumbra_like_LEL	144..267	CDD:239411	22/125 (18%)
CD81	XP_054226604.1	Tetraspanin	122..327	CDD:459767	58/245 (24%)