DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tsp3A and TSPAN10

DIOPT Version :9

Sequence 1:	NP_001245504.1	Gene:	Tsp3A / 31244	FlyBaseID:	FBgn0040334	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_001277141.2	Gene:	TSPAN10 / 83882	HGNCID:	29942	Length:	355	Species:	Homo sapiens

Alignment Length:	266	Identity:	99/266 - (37%)
Similarity:	139/266 - (52%)	Gaps:	21/266 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SQCVKYMIFLLNFVFWLFGGLLLGIGVYAFRDK---WEDANGSVRLENFYDVFLNISLVMILAGT 101
            |.||||:|||.||.|.|.|.|.|.||::....|   ..|..|.:..:..        |.:.|.|.
Human    73 SSCVKYLIFLSNFPFSLLGLLALAIGLWGLAVKGSLGSDLGGPLPADPM--------LGLALGGL 129

  Fly   102 VIFLVSFSGCVGALRENTFLLKFYSMCLLLFFLLEMAIA---IVCFVCPQYMNTFLEKQFTHKII 163
            |:..||.:|.:|||.|||.||:.:|..:|.|.:|| |:|   :|....|  :...||......|.
Human   130 VVSAVSLAGYLGALCENTCLLRGFSGGILAFLVLE-AVAGALVVALWGP--LQDSLEHTLRVAIA 191

  Fly   164 HSYRDDPDLQNFIDFAQQEFKCCGLSNSGYQDWSKNEYFNCSSPSVEKCGVPYSCCINATDISSG 228
            | |:|||||:..:|..|...:|||.::  ||||.:|.|||||||.|:.|.:|.||||:..: ...
Human   192 H-YQDDPDLRFLLDQVQLGLRCCGAAS--YQDWQQNLYFNCSSPGVQACSLPASCCIDPRE-DGA 252

  Fly   229 LVNIMCGYGVQNAPVPEATKLIWTSGCIEIVRVWAEHNLYVIAGNALGIALIQLLVIYLAKTLEG 293
            .||..||:||.......|.::::..||...:|.|...||....|.|:.:.|:|...:.||..|.|
Human   253 SVNDQCGFGVLRLDADAAQRVVYLEGCGPPLRRWLRANLAASGGYAIAVVLLQGAELLLAARLLG 317

  Fly   294 QIELQK 299
            .:..::
Human   318 ALAARR 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tsp3A	NP_001245504.1	Tetraspannin	42..295	CDD:278750	98/258 (38%)
Tsp3A	NP_001245504.1	penumbra_like_LEL	144..267	CDD:239411	46/122 (38%)
TSPAN10	NP_001277141.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		oculospanin_like_LEL	172..291	CDD:239420	47/124 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1416189at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19282
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020