Protein Alignment Tsp3A and Prph2

DIOPT Version :10

• Sequence 1: NP_525054.2
• Gene: Tsp3A / 31244
• FlyBaseID: FBgn0040334
• Length: 304
• Species: Drosophila melanogaster
• Sequence 2: NP_037153.1
• Gene: Prph2 / 25534
• RGDID: 3549
• Length: 346
• Species: Rattus norvegicus
• Alignment Length: 307
• Identity: 77/307 - (25%)
• Similarity: 126/307 - (41%)
• Gaps: 69/307 - (22%)

  Fly    47 IFLLNFVFWLFGGLLLGIGVYAFRDKWEDANGSVRLENFYDVFLNISLVMILAGTVIFLVSFSG- 110
            ::|:|::..|.|.:|..:|::.   |.|....|..::|....|:..||:.:...:.:| .|.:|
  Rat    20 LWLMNWLSVLAGIVLFSLGLFL---KIELRKRSDVMDNSESHFVPNSLIGVGVLSCVF-NSLAGK 80

  Fly   111 -CVGALRENTFL-----LKFYSMCLLLFFLLEMAIAIVCFVCPQYMNTFLEKQFTHKI---IHSY 166
             |..||....:.     ||.|....:.|.::...:|:.||:    :...||....:.:   :..|
  Rat    81 ICYDALDPAKYAKWKPWLKLYLAVCVFFNVILFLVALCCFL----LRGSLESTLAYGLKNGMKYY 141

  Fly   167 RDDPD-----LQNFIDFAQQEFKCCGLSNSGYQDWSK-----NEYFNCSSPSVEK---------- 211
            ||...     ::..||..|.||||||  |:|::||.:     |.|.:.||..|:.
  Rat   142 RDTDTPGRCFMKKTIDMLQIEFKCCG--NNGFRDWFEIQWISNRYLDFSSKEVKDRIKSNVDGRY 204

  Fly   212 --CGVPYSCCINATD---ISSGLVNIMCGYGVQNAPVPEATKL-IWTSGCIEIVRVWAEHNLYVI 270
              .|||:|||..::.   |...|.|....|...:    :..:| :|..||..     |..|.|..
  Rat   205 LVDGVPFSCCNPSSPRPCIQYQLTNNSAHYSYDH----QTEELNLWLRGCRA-----ALLNYYSS 260

  Fly   271 AGNALGIA--LIQLLVI-------YLAKTLEG-----QIELQKSRWL 303
            ..|::|:.  ||.|..:       :|...||.     ..|.:...||
  Rat   261 LMNSMGVVTLLIWLFEVSITAGLRFLHTALESVSNPEDPECESEGWL 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp3A	NP_525054.2	Tetraspanin	43..>187	CDD:459767	38/154 (25%)
		penumbra_like_LEL	144..267	CDD:239411	39/151 (26%)
Prph2	NP_037153.1	Tetraspanin	16..181	CDD:459767	44/170 (26%)
		peripherin_like_LEL	120..262	CDD:239415	41/156 (26%)
		Interaction with MREG. /evidence=ECO:0000250	341..346