Protein Alignment Tsp3A and TSPAN12

DIOPT Version :10

• Sequence 1: NP_525054.2
• Gene: Tsp3A / 31244
• FlyBaseID: FBgn0040334
• Length: 304
• Species: Drosophila melanogaster
• Sequence 2: NP_036470.1
• Gene: TSPAN12 / 23554
• HGNCID: 21641
• Length: 305
• Species: Homo sapiens
• Alignment Length: 266
• Identity: 62/266 - (23%)
• Similarity: 106/266 - (39%)
• Gaps: 44/266 - (16%)

  Fly    41 QCVKYMIFLLNFVFWLFGGLLLGIGVYAFRDKWEDA---NGSVRLEN--FYDVFLNISLVMILAG 100
            :|::.:::.||.:|||....:|.:..: .||...:.   ....|:|.  ....|..:..|||...
Human     8 KCLRCLLYALNLLFWLMSISVLAVSAW-MRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVC 71

  Fly   101 TVIFLVSFSGCVGALRENTFLLKFYSMCLLLFFLLEMAIAIVCF-----VCPQYMN-TFLEKQFT 159
            ..:.:|...|..|.::.|..||.:|...||:.|.:|:|..:..:     |..|:.: ..|:.:.|
Human    72 CFLIIVGMLGYCGTVKRNLLLLAWYFGSLLVIFCVELACGVWTYEQELMVPVQWSDMVTLKARMT 136

  Fly   160 HKIIHSYRDDPDLQNFIDFAQQEFKCCGLSNSGYQDWSKNEYFNCSSPSVEKCGVPYSCCINATD 224
            :..:..||   .|.:..:|.|:||||||:..  :.||.:         ..|....|.|||:....
Human   137 NYGLPRYR---WLTHAWNFFQREFKCCGVVY--FTDWLE---------MTEMDWPPDSCCVREFP 187

  Fly   225 ISSGLVNIMCGYGVQNAPVPEATKLIWTSGC----IEIVRVWAEHNLYVIAGNALGIALIQLLVI 285
                        |.......|....::..||    ...:|  ....|.|:....:.|.:.|:|.:
Human   188 ------------GCSKQAHQEDLSDLYQEGCGKKMYSFLR--GTKQLQVLRFLGISIGVTQILAM 238

  Fly   286 YLAKTL 291
            .|..||
Human   239 ILTITL 244

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp3A	NP_525054.2	Tetraspanin	43..>187	CDD:459767	39/154 (25%)
		penumbra_like_LEL	144..267	CDD:239411	27/132 (20%)
TSPAN12	NP_036470.1	Tetraspanin	10..246	CDD:459767	61/264 (23%)
		TM4SF12_like_LEL	116..218	CDD:239410	27/129 (21%)