Protein Alignment Tsp3A and TSPAN5

DIOPT Version :10

• Sequence 1: NP_525054.2
• Gene: Tsp3A / 31244
• FlyBaseID: FBgn0040334
• Length: 304
• Species: Drosophila melanogaster
• Sequence 2: NP_005714.2
• Gene: TSPAN5 / 10098
• HGNCID: 17753
• Length: 268
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 115/288 - (39%)
• Similarity: 165/288 - (57%)
• Gaps: 26/288 - (9%)

  Fly    19 GRGYSGIEVHEVMHPHHFTYVSQCVKYMIFLLNFVFWLFGGLLLGIGVYAFRDKWEDANGS--VR 81
            |:.|.|.|            ||.|:||.||..|.:||..|...||||::|:.:|...:|.|  ..
Human     3 GKHYKGPE------------VSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITD 55

  Fly    82 LENFYDVFLNISLVMILAGTVIFLVSFSGCVGALRENTFLLKFYSMCLLLFFLLEMAIAIVCFVC 146
            |..|..|:|     .::.|.|:|::.|:||:||||||||||||:|:.|.:.|.||:...::.||.
Human    56 LGGFDPVWL-----FLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVF 115

  Fly   147 PQYMNTFLEKQFTHKIIHSYRDDPDLQNFIDFAQQEFKCCGLSNSGYQDWSKNEYFNC--SSPSV 209
            ..::...| ..|.:..|.:||||.||||.|||.|:.::|||.  .|..||:.|.||||  |:.|.
Human   116 KDWIKDQL-YFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGA--FGADDWNLNIYFNCTDSNASR 177

  Fly   210 EKCGVPYSCCINATDISSGLVNIMCGYGVQNAPVPEATKLIWTSGCIEIVRVWAEHNLYVIAGNA 274
            |:||||:|||  ..|.:..::|..|||..:..|..:...:|:|.||:.....|.:.||.::||..
Human   178 ERCGVPFSCC--TKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIF 240

  Fly   275 LGIALIQLLVIYLAKTLEGQIELQKSRW 302
            :||||:|:..|.||:.|...||..::.|
Human   241 IGIALLQIFGICLAQNLVSDIEAVRASW 268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tsp3A	NP_525054.2	Tetraspanin	43..>187	CDD:459767	61/145 (42%)
		penumbra_like_LEL	144..267	CDD:239411	49/124 (40%)
TSPAN5	NP_005714.2	Tetraspanin	15..258	CDD:459767	104/252 (41%)
		TM4SF9_like_LEL	113..233	CDD:239412	49/124 (40%)