DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and EIF3G

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_003746.2	Gene:	EIF3G / 8666	HGNCID:	3274	Length:	320	Species:	Homo sapiens

Alignment Length:	313	Identity:	130/313 - (41%)
Similarity:	171/313 - (54%)	Gaps:	52/313 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSSWADEVE------------------------------LDYGGLPPTTETVENGQKYVTEYKYN 42
            |.||||:||                              |....|||..|.:....|.|||||.:
Human     9 KPSWADQVEEEGEDDKCVTSELLKGIPLATGDTSPEPELLPGAPLPPPKEVINGNIKTVTEYKID 73

  Fly    43 KDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGDSKNDKPGPNSQTTMVSEEIIMQFLNSKED-- 105
            :|.||.|:|||::|..:...|.||:|:.|.|||:|:.|.||||..||.||:::.|.|:.||||
Human    74 EDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLN 138

  Fly   106 -EKANDPL--LDPTKNIAKCRICNGEHWSVNCPYKGT------------AMDTNMMEKKASAAAA 155
             ::..||:  |...| |..||||.|:||:..||||.|            .:.|...||.......
Human   139 CQEEEDPMNKLKGQK-IVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEP 202

  Fly   156 AAVDAPKSGKYVPPFLKD--SQKGALGMRGR--DDTAAIRISNLSESMTEADLEELVKKIGPQSK 216
            ......|:||||||.|:|  |::|......|  ||.|.||::||||...|.||:||.:..|..|:
Human   203 VQATQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISR 267

  Fly   217 MYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN 269
            :|||:||.||..||||::.|.:|:|||.||..::|.|||||||:|||:||..|
Human   268 IYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	55/126 (44%)
		RRM	<161..>269	CDD:223796	59/111 (53%)
		RRM_eIF3G_like	189..265	CDD:240854	42/75 (56%)
EIF3G	NP_003746.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..59		11/49 (22%)
		eIF3G	62..173	CDD:240597	53/111 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..234		11/24 (46%)
		RRM_eIF3G_like	240..315	CDD:409842	41/74 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153871
Domainoid	1	1.000	125	1.000	Domainoid score	I5488
eggNOG	1	0.900	-	-		E1_KOG0122
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2784
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3411
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55427
OrthoDB	1	1.010	-	-		D1226059at2759
OrthoFinder	1	1.000	-	-		FOG0003558
OrthoInspector	1	1.000	-	-		otm40478
orthoMCL	1	0.900	-	-		OOG6_102687
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R382
SonicParanoid	1	1.000	-	-		X2433
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840