DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and GBP2

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_009916.1	Gene:	GBP2 / 850346	SGDID:	S000000517	Length:	427	Species:	Saccharomyces cerevisiae

Alignment Length:	254	Identity:	54/254 - (21%)
Similarity:	85/254 - (33%)	Gaps:	79/254 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 EVELDYGGLPPTTETVENGQKYVTEYKYNKDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGDSK 78
            :||||:.|......:|          .|..:|:..:.:.|:. ..:|..:.:..|.  .:|...|
Yeast   249 DVELDFNGFSRGFGSV----------IYPTEDEMIRAIDTFN-GMEVEGRVLEVRE--GRFNKRK 300

  Fly    79 NDKPGPNSQTTMVSEEIIMQFLNSKEDEKANDPLLDPTKNIAKCRICNGEHWSVNCPYKGTAMDT 143
            |     |.:.....|::        ||.:..:|                          |.|.|
Yeast   301 N-----NDRYNQRREDL--------EDTRGTEP--------------------------GLAQD- 325

  Fly   144 NMMEKKASAAAAAAVD--APKSGKYVPPFLKDSQKGALGMRGRDDTAAIRISNLSESMTEADLEE 206
                      ||..:|  |.|..:.|.|             |.|....|..|||..|...:||.:
Yeast   326 ----------AAVHIDETAAKFTEGVNP-------------GGDRNCFIYCSNLPFSTARSDLFD 367

  Fly   207 LVKKIGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSK 265
            |...||..:...|...:| |...|.|.|.::...||...|:.||.:.|....|.:.:::
Yeast   368 LFGPIGKINNAELKPQEN-GQPTGVAVVEYENLVDADFCIQKLNNYNYGGCSLQISYAR 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	14/109 (13%)
		RRM	<161..>269	CDD:223796	28/105 (27%)
		RRM_eIF3G_like	189..265	CDD:240854	23/75 (31%)
GBP2	NP_009916.1	RRM1_HRB1_GBP2	121..197	CDD:410184
		RRM2_HRB1_GBP2	218..292	CDD:410185	10/53 (19%)
		RRM3_HRB1_GBP2	347..425	CDD:410186	23/78 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910