DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and TIA1

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_071505.2	Gene:	TIA1 / 7072	HGNCID:	11802	Length:	386	Species:	Homo sapiens

Alignment Length:	188	Identity:	46/188 - (24%)
Similarity:	75/188 - (39%)	Gaps:	31/188 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 VSEEIIMQFLNSKEDEKANDPLLDPTKNIAKCRICNGEHWSVNCPYKGTAMDTNMMEKKASAAAA 155
            |:|.:|:|..:.          :.|.||   |::....  :.|.||    ......|.:.:|||.
Human    18 VTEALILQLFSQ----------IGPCKN---CKMIMDT--AGNDPY----CFVEFHEHRHAAAAL 63

  Fly   156 AAVDAPK-SGKYV-------PPFLK--DSQKGALGMRGRDDTAAIRISNLSESMTEADLEELVKK 210
            ||::..| .||.|       |...|  .|....:..:...|...:.:.:||..:|..|::.....
Human    64 AAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAP 128

  Fly   211 IGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWS--KP 266
            .|..|...:.:|..||..||:.:|.|..:.||..||:.:.|.......:...|:  ||
Human   129 FGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKP 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	11/48 (23%)
		RRM	<161..>269	CDD:223796	29/118 (25%)
		RRM_eIF3G_like	189..265	CDD:240854	19/77 (25%)
TIA1	NP_071505.2	RRM1_TIA1	8..81	CDD:410027	21/81 (26%)
		RRM2_TIA1	104..181	CDD:410030	19/76 (25%)
		RRM3_TIAR	214..286	CDD:241064
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910