DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and CELF6

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_443072.3	Gene:	CELF6 / 60677	HGNCID:	14059	Length:	481	Species:	Homo sapiens

Alignment Length:	177	Identity:	44/177 - (24%)
Similarity:	66/177 - (37%)	Gaps:	21/177 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 PGPNSQTTMVSEEIIMQFLNSKE---DEKANDPLLDPTKNIAKCRI----CNGEHWSVNCPYKGT 139
            |||  ...|...:.|..|:....   ||:...||.:....|.:..:    ..|.|       ||.
Human    34 PGP--AVPMKDHDAIKLFVGQIPRGLDEQDLKPLFEEFGRIYELTVLKDRLTGLH-------KGC 89

  Fly   140 AMDTNMMEKKASAAAAAAVDAPKSGKYVPPFLKDSQKGALGMRGRDDTAAIRISNLSESMTEADL 204
            |..|..    |..:|..|..|....|.:|...:..|.......||.:...:.:..|.:...|.|:
Human    90 AFLTYC----ARDSALKAQSALHEQKTLPGMNRPIQVKPAASEGRGEDRKLFVGMLGKQQGEEDV 150

  Fly   205 EELVKKIGPQSKMYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNG 251
            ..|.:..|...:..:.|..: |..||.|:|.|..:.:|.|||..|:|
Human   151 RRLFQPFGHIEECTVLRSPD-GTSKGCAFVKFGSQGEAQAAIRGLHG 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	15/64 (23%)
		RRM	<161..>269	CDD:223796	23/91 (25%)
		RRM_eIF3G_like	189..265	CDD:240854	18/63 (29%)
CELF6	NP_443072.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34		44/177 (25%)
		RRM1_CELF3_4_5_6	41..127	CDD:241076	20/96 (21%)
		ELAV_HUD_SF	48..477	CDD:273741	39/161 (24%)
		RRM2_CELF3_4_5_6	133..213	CDD:241079	18/65 (28%)
		RRM3_CELF3_4_5_6	392..470	CDD:241083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910