DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and eif3g

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_957293.1	Gene:	eif3g / 393974	ZFINID:	ZDB-GENE-040426-1076	Length:	293	Species:	Danio rerio

Alignment Length:	294	Identity:	138/294 - (46%)
Similarity:	179/294 - (60%)	Gaps:	26/294 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPGVE--TIKSSWADEVEL--DYGGLPPTTETVENGQKYVTEYKYNKDDKKTKVVRTYKISKQVV 61
            ||.:|  ..|.||||:||.  |.|.||...|||:...|.|||||.:.|.:|.|::||:||..:..
Zfish     1 MPSIEFDDSKPSWADQVEEEGDEGSLPSPKETVKGNIKTVTEYKIDDDGQKFKIIRTFKIETRKA 65

  Fly    62 PKTVAKRRTWTKFGDSKNDKPGPNSQTTMVSEEIIMQFLNSKEDEKANDPLLDPT-----KNIAK 121
            .|.||:|:.|.|||:|:.|.||||..||.||:::.|.|::||||..|.|...||.     :.|..
Zfish    66 SKAVARRKNWKKFGNSEYDAPGPNVATTTVSDDVFMTFISSKEDLNAQDQDEDPMNKLEGQKIVS 130

  Fly   122 CRICNGEHWSVNCPYKGT------------AMDTNMMEKKASAAAAAAVDAPKSGKYVPPFLKD- 173
            ||||.|:||:..||||.|            .:.|...||.|....|..|. .|:||||||.|:|
Zfish   131 CRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKAAEPEPAQPVQ-NKTGKYVPPSLRDG 194

  Fly   174 -SQKGALGMRGR--DDTAAIRISNLSESMTEADLEELVKKIGPQSKMYLARDKNTGLCKGFAYVH 235
             :::|......|  ||.|.||::||||...|.||:||.:..|..|::|||:|||||..||||.:.
Zfish   195 GTRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISRIYLAKDKNTGQSKGFALIS 259

  Fly   236 FKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN 269
            |.:|:|||.||..::|.|||||||:|||:||.||
Zfish   260 FHRREDAARAIAGVSGFGYDHLILNVEWAKPSNN 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	54/126 (43%)
		RRM	<161..>269	CDD:223796	59/111 (53%)
		RRM_eIF3G_like	189..265	CDD:240854	43/75 (57%)
eif3g	NP_957293.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		14/30 (47%)
		eIF3G	35..147	CDD:240597	52/111 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..206		16/43 (37%)
		RRM	<172..>293	CDD:223796	61/121 (50%)
		RRM_eIF3G_like	213..289	CDD:240854	43/75 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589063
Domainoid	1	1.000	130	1.000	Domainoid score	I5169
eggNOG	1	0.900	-	-		E1_KOG0122
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2784
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3194
OMA	1	1.010	-	-		QHG55427
OrthoDB	1	1.010	-	-		D1226059at2759
OrthoFinder	1	1.000	-	-		FOG0003558
OrthoInspector	1	1.000	-	-		otm25678
orthoMCL	1	0.900	-	-		OOG6_102687
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R382
SonicParanoid	1	1.000	-	-		X2433
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	16	15.840