DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and HNRNPA1

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens

Alignment Length:	151	Identity:	35/151 - (23%)
Similarity:	57/151 - (37%)	Gaps:	38/151 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 EHWSVNCPYKGTAMDTNMME----KKA------SAAAAAAVDAPKS-------GKYVPP----FL 171
            |.|       ||..|..:|.    |::      :.|....|||..:       |:.|.|    ..
Human    35 EQW-------GTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSR 92

  Fly   172 KDSQKGALGMRGRDDTAAIRISNLSESMTEADLEELVKKIGPQSKMYLARDKNTGLCKGFAYVHF 236
            :|||:....:    ....|.:..:.|...|..|.:..::.|....:.:..|:.:|..:|||:|.|
Human    93 EDSQRPGAHL----TVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTF 153

  Fly   237 KQRKDAAAAIEI-----LNGH 252
            ... |:...|.|     :|||
Human   154 DDH-DSVDKIVIQKYHTVNGH 173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	3/11 (27%)
		RRM	<161..>269	CDD:223796	24/108 (22%)
		RRM_eIF3G_like	189..265	CDD:240854	18/69 (26%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		14/65 (22%)
		RRM1_hnRNPA1	12..92	CDD:410154	14/63 (22%)
		Globular B domain	95..185		20/84 (24%)
		RRM2_hnRNPA3	105..184	CDD:409996	18/70 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216
		RNA-binding RGG-box	218..240
		HnRNPA1	307..344	CDD:402981
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372
		Nuclear targeting sequence (M9)	320..357
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910