DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF3g1 and Eif3g

DIOPT Version :9

Sequence 1:	NP_570011.1	Gene:	eIF3g1 / 31243	FlyBaseID:	FBgn0029629	Length:	269	Species:	Drosophila melanogaster
Sequence 2:	NP_001013113.1	Gene:	Eif3g / 298700	RGDID:	1307191	Length:	320	Species:	Rattus norvegicus

Alignment Length:	313	Identity:	130/313 - (41%)
Similarity:	170/313 - (54%)	Gaps:	52/313 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KSSWADEVE------------------------------LDYGGLPPTTETVENGQKYVTEYKYN 42
            |.||||:||                              |....|||..|.:....|.|||||..
  Rat     9 KPSWADQVEEEGEDDKCVTSELLKGIPLPTGDTSPEPELLPGDPLPPPKEVINGNIKTVTEYKVE 73

  Fly    43 KDDKKTKVVRTYKISKQVVPKTVAKRRTWTKFGDSKNDKPGPNSQTTMVSEEIIMQFLNSKED-- 105
            :|.||.|:|||::|..:...|.||:|:.|.|||:|:.|.||||..||.||:::.|.|:.||||
  Rat    74 EDGKKFKIVRTFRIETRKASKAVARRKNWKKFGNSEFDPPGPNVATTTVSDDVSMTFITSKEDLN 138

  Fly   106 -EKANDPL--LDPTKNIAKCRICNGEHWSVNCPYKGT------------AMDTNMMEKKASAAAA 155
             ::..||:  |...| |..||||.|:||:..||||.|            .:.|...||.......
  Rat   139 CQEEEDPMNKLKGQK-IVSCRICKGDHWTTRCPYKDTLGPMQKELAEQLGLSTGEKEKLPGELEP 202

  Fly   156 AAVDAPKSGKYVPPFLKD--SQKGALGMRGR--DDTAAIRISNLSESMTEADLEELVKKIGPQSK 216
            ......|:||||||.|:|  |::|......|  ||.|.||::||||...|.||:||.:..|..|:
  Rat   203 VQAAQNKTGKYVPPSLRDGASRRGESMQPNRRADDNATIRVTNLSEDTRETDLQELFRPFGSISR 267

  Fly   217 MYLARDKNTGLCKGFAYVHFKQRKDAAAAIEILNGHGYDHLILSVEWSKPQNN 269
            :|||:||.||..||||::.|.:|:|||.||..::|.|||||||:|||:||..|
  Rat   268 IYLAKDKTTGQSKGFAFISFHRREDAARAIAGVSGFGYDHLILNVEWAKPSTN 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF3g1	NP_570011.1	eIF3g	30..140	CDD:289149	55/126 (44%)
		RRM	<161..>269	CDD:223796	59/111 (53%)
		RRM_eIF3G_like	189..265	CDD:240854	42/75 (56%)
Eif3g	NP_001013113.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60		12/50 (24%)
		eIF3G	62..173	CDD:240597	53/111 (48%)
		RRM	180..>317	CDD:223796	60/136 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..233		11/27 (41%)
		RRM_eIF3G_like	240..316	CDD:240854	42/75 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347460
Domainoid	1	1.000	124	1.000	Domainoid score	I5393
eggNOG	1	0.900	-	-		E1_KOG0122
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2784
Inparanoid	1	1.050	234	1.000	Inparanoid score	I3326
OMA	1	1.010	-	-		QHG55427
OrthoDB	1	1.010	-	-		D1226059at2759
OrthoFinder	1	1.000	-	-		FOG0003558
OrthoInspector	1	1.000	-	-		otm44619
orthoMCL	1	0.900	-	-		OOG6_102687
Panther	1	1.100	-	-	LDO	PTHR10352
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2433
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810