Protein Alignment Klp3A and KIP2

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_015170.1
• Gene: KIP2 / 855948
• SGDID: S000006076
• Length: 706
• Species: Saccharomyces cerevisiae
• Alignment Length: 780
• Identity: 186/780 - (23%)
• Similarity: 284/780 - (36%)
• Gaps: 313/780 - (40%)

  Fly    49 YTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVI 113
            :.:::||....:..:::|...:..:.|||.|:|.||.|||.||||||:||...     :..:|:|
Yeast   163 FKFDHVFASHCTNLEVYERTSKPMIDKLLMGFNATIFAYGMTGSGKTFTMSGN-----EQELGLI 222

  Fly   114 PRAVHDIFTAIAE--MQSEFRFAVTCSFVELYQEQFYDLFSS----------------------- 153
            |.:|..:||.|.|  |..:.:|.|..|::|:|.|:.|||..|
Yeast   223 PLSVSYLFTNIMEQSMNGDKKFDVIISYLEIYNERIYDLLESGLEESGSRISTPSRLYMSKSNSN 287

  Fly   154 ------KTRDKATVDIREVKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSH 212
                  |.||.:...::.:       ||||....|::::...:..|...|.:..|..|..|||||
Yeast   288 GLGVELKIRDDSQYGVKVI-------GLTERRCESSEELLRWIAVGDKSRKIGETDYNARSSRSH 345

  Fly   213 AIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASG--DRFKEGVNINKGLLALGNVINA 275
            ||..:.|.:|.:....| .:|..:|.|||||||     |:|  :|.|||..|||.|||||.||:.
Yeast   346 AIVLIRLTSTNVKNGTS-RSSTLSLCDLAGSER-----ATGQQERRKEGSFINKSLLALGTVISK 404

  Fly   276 L------------------GSGQAAG-----------YIPYRQSKLTRLLQDSLGGNSITLMIAC 311
            |                  ||..::|           :||||.||||||||.:|.|:||...|..
Yeast   405 LSADKMNSVGSNIPSPSASGSSSSSGNATNNGTSPSNHIPYRDSKLTRLLQPALSGDSIVTTICT 469

  Fly   312 VSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLSGGKMSSSLIS 376
            |...:...|||::|||:|.||
Yeast   470 VDTRNDAAAETMNTLRFASRA-------------------------------------------- 490

  Fly   377 AVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAE 441
                                                                    |.:..|:::
Yeast   491 --------------------------------------------------------KNVALHVSK 499

  Fly   442 QAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEELESQGHESR 506
                  :|.:|               |.|.:||.:                ||.|.|..|..|.|
Yeast   500 ------KSIIS---------------NGNNDGDKD----------------RTIELLRRQLEEQR 527

  Fly   507 QRLS---SRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNF 568
            :.:|   :||:          :.|.|...|.|.|.|.:...|
Yeast   528 RMISELKNRSN----------IGEPLTKSSNESTYKDIKATG----------------------- 559

  Fly   569 SRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRR 633
                 :|.|..|.|       :.||.|.|..:|.|.:                :||::::.||
Yeast   560 -----NDGDPNLAL-------MRAENRVLKYKLENCE----------------KLLDKDVVDL-- 594

  Fly   634 KLITQANLLKIRDKE-REKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSK 697
                       :|.| .|.::.|..|:.|:.|:|   .:.:..:..::|::....|.::..|:..
Yeast   595 -----------QDSEIMEIVEMLPFEVGTLLETK---FQGLESQIRQYRKYTQKLEDKIMALEKS 645

  Fly   698 DRKMQS-------EIVR-QQTLHSKQRQVLKRKCEEALAANKRLKD-ALERQASAQAQRHKYKDN 753
            .....|       |::. |:.|..|.:.:      |||.:.|||:| ||:...:.|...|...||
Yeast   646 GHTAMSLTGCDGTEVIELQKMLERKDKMI------EALQSAKRLRDRALKPLINTQQSPHPVVDN 704

  Fly   754  753
            Yeast   705  704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	118/348 (34%)
		Smc	<453..>985	CDD:440809	64/314 (20%)
		Metallothio	<1071..1115	CDD:395080
KIP2	NP_015170.1	KISc_CENP_E	102..493	CDD:276825	119/447 (27%)
		SMC_prok_B	<445..>698	CDD:274008	90/472 (19%)