Protein Alignment Klp3A and KIP3

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_011299.1
• Gene: KIP3 / 852655
• SGDID: S000003184
• Length: 805
• Species: Saccharomyces cerevisiae
• Alignment Length: 681
• Identity: 191/681 - (28%)
• Similarity: 308/681 - (45%)
• Gaps: 120/681 - (17%)

  Fly    49 YTYNYVFDIDDSQKDLFETCVQAKVKKLLNGYNVTILAYGQTGSGKTYTM-GTAFNGVLDDHVGV 112
            :.::.:||...||..:::......:..:|:|:|.|:.|||.||.|||||: ||      ....|:
Yeast   153 FVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSGT------PSQPGI 211

  Fly   113 IPRAVHDIFTAIAEMQSEFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIREVKNRIIMPGLTE 177
            |..|:.::|..|.:::.|..|.::.|::|:|.|:..||...:|..|..|...:.:|.|.:..|:.
Yeast   212 IFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIREDTQNHIKVANLSY 276

  Fly   178 LVVTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK--LDGKQSVTTSRFNLVDL 240
            ....:.:.|.|.:::|:..|..:.|..||.||||||:..:.::.|.  :|.....|.:..:::||
Yeast   277 HHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVDLTSQHTFATLSIIDL 341

  Fly   241 AGSERCSKTLASGDRFKEGVNINKGLLALGNVINA--LGSGQAAGYIPYRQSKLTRLLQDSLGGN 303
            |||||.:.|...|.|..||.|||:.||||||.|||  |..|..:.:||||.|||||||:.|||||
Yeast   342 AGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSRSCHIPYRDSKLTRLLKFSLGGN 406

  Fly   304 SITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVN---LDPHAA-----------EVNMLK 354
            ..|:||.|:||:..:..|||:||:||:||.:||.|.:.|   |..|..           ::..|:
Yeast   407 CKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTKIIRNQQSLSRHVGSYLKMITEQKRQIEELR 471

  Fly   355 DVIQKLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKL 419
            :..:|:....|:..|::...|.      |....|...:..:.|.....|..|.....:..:.|.|
Yeast   472 EREEKMISLKLTKYKLNKEKIQ------LAINECVNRVQQTYAGVETYQVAKTLKSLILCKRRFL 530

  Fly   420 QQ---ELHQSLL-----DLTEKEMRAHIA--EQAHDKLRSHVSELKNKLDQREQA-----QFGNE 469
            |.   |:...:|     :.|..||:..|:  .....:|.:.:.||:.|.|:.:..     |..:.
Yeast   531 QMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMKFDETDTLSSVIHQVHSI 595

  Fly   470 NTNGDNEMRDFSLLVNRVHV--------ELQR----------TQEELESQGHESRQRLSSR---S 513
            :.|...||.|:....:.|::        ||||          |::.:...|..||.:..|:   :
Yeast   596 DLNKLREMEDWDETYDLVYLESCLNQISELQRNEILVNSSIMTEKLMSDPGLNSRFKFLSKWLMN 660

  Fly   514 HTEGGESGGDEVHEMLHSHSEEY--------TNKQMNFAGELRNIN------RQLDLKQELHERI 564
            .|...||   .:.:::|. .||:        .|...||..  .|||      ..|.:..|..:|
Yeast   661 RTPNIES---IIQDLVHI-DEEFESFARTFIANPDSNFTN--TNINIINTTAADLAVPAETLQR- 718

  Fly   565 MRNFS--RLDSDDEDVKLRLCNQKIDDLEAERRDLMDQLRNIKSKDISAK--------------- 612
             :|||  ::.....|:......:...:||.|.....|.:.:  ..|:|.:
Yeast   719 -QNFSQKKVKWTSPDLSPSPMIEPQPELEPELHQDQDAIAS--EVDVSMQDTTFNEQGPSTPSAP 780

  Fly   613 -LAEERRKRLQLLEQEISDLRRKLITQANLL 642
             .|..|||           :|..|:|..:||
Yeast   781 TTAVPRRK-----------MRSSLLTHQSLL 800

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	112/291 (38%)
		Smc	<453..>985	CDD:440809	53/248 (21%)
		Metallothio	<1071..1115	CDD:395080
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	112/290 (39%)