Protein Alignment Klp3A and Kif4a

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_001387859.1
• Gene: Kif4a / 84393
• RGDID: 620526
• Length: 1231
• Species: Rattus norvegicus
• Alignment Length: 1312
• Identity: 430/1312 - (32%)
• Similarity: 684/1312 - (52%)
• Gaps: 209/1312 - (15%)

  Fly     9 VAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQAKV 73
            |.||||.||||..|::.||:..:. ...|.|||.|..::|:||::|||....|:::|.|.|...:
  Rat    10 VRVALRCRPLVSKEINEGCQTCLS-FVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVFNTAVAPLI 73

  Fly    74 KKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVL--DDHVGVIPRAVHDIFTAIAEMQSEFRFAVT 136
            |.:..|||.|:||||||||||||:||.|:....  |..:|||||.:..:|..| ..:::|.|.:.
  Rat    74 KGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQEHDSAIGVIPRVIQLLFKEI-NKKTDFEFTLK 137

  Fly   137 CSFVELYQEQFYDLFSSKTRDKAT-VDIRE-VKNRIIMPGLTELVVTSAQQVTDHLIRGSAGRAV 199
            .|::|:|.|:..||..| :|:||: ::||| .|..|.:.||||..|..|......|.:|:..|.|
  Rat   138 VSYLEIYNEEILDLLCS-SREKASQINIREDPKEGIKIVGLTEKTVLVASDTVSCLEQGNNCRTV 201

  Fly   200 AATAMNETSSRSHAIFTLTLVATKLDGKQSVTTSRFNLVDLAGSERCSKTLASGDRFKEGVNINK 264
            |:||||..|||||||||:::...|.:.|.|...|:.:|||||||||..||.|.|||.|||:|||:
  Rat   202 ASTAMNSQSSRSHAIFTISIEQRKKNDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININR 266

  Fly   265 GLLALGNVINALGSGQAAGYIPYRQSKLTRLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYA 329
            |||.|||||:|||..:...::|||.|||||||||||||||.|||||||||||.|:.|||:|||||
  Rat   267 GLLCLGNVISALGDDKKGNFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYA 331

  Fly   330 DRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS--GGKMSSSLISAVGAAGLGAIPCEESL 392
            |||.:|||||::|:||.|||:|.||..:|:|:|.||.  ||.:..::
  Rat   332 DRARKIKNKPIINIDPQAAELNHLKQQVQQLQVLLLQAHGGTLPGNI------------------ 378

  Fly   393 AGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKN- 456
              ::..:..:|.|.|:.::|.:.|.||.:.|.::.....:...|..:.|||::|:.:.:.||:.
  Rat   379 --NVKPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQH 441

  Fly   457 ---KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVELQRTQEE--------LESQGHESRQRLS 510
               |:|.::.|:     |..|.|:::...::..:...:.|..:|        :::.|....|..|
  Rat   442 AACKVDLQKLAE-----TLEDQEVKENIEIICNLQQAIARLSDEAVACMTATIDTAGEVDTQEQS 501

  Fly   511 SRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQLDLKQELHERIMRNFSRLDSDD 575
            |...:...:           ..|.::..:|...:.||..:|::|.||:.|.:::.:|.::|....
  Rat   502 SPDTSRSSD-----------VFSTQHALRQAQMSKELIELNKELALKEALAKKMTQNDNQLQPIQ 555

  Fly   576 EDVKLRLCNQKID--DLEAERRDLMDQLRNIKSKDIS-AKLAEERRKRLQLLEQEISDLRRKLIT 637
            ...:..:.|.:::  .|:.|:.:|:.:|:..| ||:: |||:|.||||||.||.:|::|::||..
  Rat   556 FQYQDNIKNLELEVLSLQKEKEELVLELQTAK-KDVNQAKLSERRRKRLQELEGQIAELKKKLHE 619

  Fly   638 QANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQ 702
            |:.|||:::.....:..|:.|||.||..:|:|:|.|:.::|||||||..::||:.|||.:|||.|
  Rat   620 QSKLLKLKETTELTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQQKDKEVIQLKERDRKRQ 684

  Fly   703 SEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQASAQAQRHKYKDNG--GSAAGSSNANA 765
            .|:::.:....||..||:||.|||.||||||||||::|.....:|.:.:..|  |:|       |
  Rat   685 YELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQKEVAEKRKETQSRGMEGTA-------A 742

  Fly   766 KTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQQEKTS------------------- 811
            :..||:..|:|:::|..:|:..|..|:|:|.::......|::::.|
  Rat   743 RMKSWLGNEIEVMVSTEEAKRHLNDLLEERKILAQDVAQLKEKRESGENPPPKLRRRTFSRDEVH 807

  Fly   812 --DPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRIRSLAEGVQSLGESRTVSK--- 871
              |.......::.:.|||.|||:|:|||:|||||:...:.:.:.:...|.:.::.|::...|
  Rat   808 GQDSGAEDSISKQIESLESELELRSAQIADLQQKLLDAESEDQPKQRWENIATILEAKCAIKYLV 872

  Fly   872 -QLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQ----EDAASKRLRLLQSQHEEQML--- 928
             :|:.:.:|..:|: |.|::.:.:..|::..|.:.|..    |....:.|..::.||:|::|
  Rat   873 GELVSSKIQVSKLE-SGLSQSKASCIEVQKMLFEEQNHFAKIETELKEELVRVEQQHQEKVLYLL 936

  Fly   929 -------AQQRAYEEKVS----VLIRTANQRWAEARSPAEDQQRNQILEELLSSREALQQELDKL 982
                   ..::..||.||    .|:.|...:..|.|...|..::||   :||....|::|:|:.|
  Rat   937 SQLQQCQVTEKQLEESVSEKEQQLLSTLKCQEEELRKMQEVCEQNQ---QLLQENSAIKQKLNLL 998

  Fly   983 RAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVSDDPDWVPSTSKSKRIQSDSRNVISPPEK 1047
            :..:|.|...|::..|..|.||                  :::|...|..||:...      |||
  Rat   999 QVVSKEKPHLVRNILQSPDSSF------------------EYIPPKPKPFRIKEKC------PEK 1039

  Fly  1048 QDANVTSLGNSSIQSLNSTSATED----------------------GKRCKGCKCRTKCTTKRCG 1090
                  |.....:|..:.||..|:                      .|..:||.|:..|..|:||
  Rat  1040 ------SFAIEDLQYYSETSVAEEENEDSDDHADEEWIPTKLVKVSKKNIQGCSCKGWCGNKQCG 1098

  Fly  1091 CLSGNNACSETCVC-KSNCRNPLNLKDHASQCGDGDGQKDETEDADKSDDDGDDEPQTSKENAVK 1154
            |....:.|:..|.| .:.|||    :.|:....|......::|::.|.:|      .|...:.:.
  Rat  1099 CRKQKSDCNGACSCDPTKCRN----RHHSQDNSDVIELNQDSENSFKLED------PTEVTSGLS 1153

  Fly  1155 FVTPEAPGKVVASPKQ------------TLQEPKAAAT-------PLMNSNVVEDINGPKLAKMS 1200
            |..|     |..:|..            .|::|..|::       |:.:........|.|  |..
  Rat  1154 FFNP-----VCTTPSSKILKEMCDADQVLLRQPDFASSSDHLELKPIASETQENKAMGKK--KKR 1211

  Fly  1201 GLAFDTPKRKFF 1212
            .||.:|   .||
  Rat  1212 ALASNT---SFF 1220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	173/330 (52%)
		Smc	<453..>985	CDD:440809	167/591 (28%)
		Metallothio	<1071..1115	CDD:395080	15/66 (23%)
Kif4a	NP_001387859.1	KISc_KIF4	8..338	CDD:276823	173/330 (52%)
		PTZ00121	<397..1039	CDD:173412	188/693 (27%)
		SMC_prok_B	550..>865	CDD:274008	111/322 (34%)
		SET	1084..>1121	CDD:394802	14/40 (35%)