DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and AT5G60930

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_001332385.1	Gene:	AT5G60930 / 836214	AraportID:	AT5G60930	Length:	1335	Species:	Arabidopsis thaliana

Alignment Length:	1301	Identity:	390/1301 - (29%)
Similarity:	610/1301 - (46%)	Gaps:	271/1301 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EDPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQ-KDLFET 67
            |...||.||:.:|||:..||..||...: ..|...|||.:. :.::||::|:...... .:::..
plant     2 ESTECVRVAVNIRPLITPELLNGCTDCI-TVAPKEPQVHIG-SHTFTYDFVYGNGGYPCSEIYNH 64

  Fly    68 CVQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAIAEMQSEFR 132
            ||...|..|..|||.|:||||||||||||||||.::|...:. ||||..:.|||..:...:....
plant    65 CVAPLVDALFKGYNATVLAYGQTGSGKTYTMGTNYSGDCTNG-GVIPNVMEDIFRRVETTKDSSE 128

  Fly   133 FAVTCSFVELYQEQFYDLFSSKTR----------------DKATVDIRE-VKNRIIMPGLTELVV 180
            ..:..||:|:::|:.:||..|.:.                .:|.:.||| ....|.:.|:||..|
plant   129 LLIRVSFIEIFKEEVFDLLDSNSSALLKNDSGVQAKHTALSRAPIQIRETASGGITLAGVTEAEV 193

  Fly   181 TSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATKL---------DGKQSVTTSRFN 236
            .:.:::...|.|||..||..:|.||..|||||||||:||...|:         ||.:.:..::.:
plant   194 KTKEEMGSFLARGSLSRATGSTNMNSQSSRSHAIFTITLEQKKIAGGSCTTTEDGGEDILCAKLH 258

  Fly   237 LVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALG---SGQAAGYIPYRQSKLTRLLQD 298
            |||||||||..:|.|.|.|.|||::||||||||||||:|||   ..:..|::|||.|||||||||
plant   259 LVDLAGSERAKRTGADGMRLKEGIHINKGLLALGNVISALGDEKKRKEGGHVPYRDSKLTRLLQD 323

  Fly   299 SLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVE 363
            ||||||.|:|||||||||.|..|||:||:||:||..|:||.|:|.||..|::..::..|::|:.|
plant   324 SLGGNSKTVMIACVSPADTNAEETLNTLKYANRARNIQNKAVINRDPATAQMQRMRSQIEQLQTE 388

  Fly   364 LLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQELHQSLL 428
            ||                         ...|......|:|.||.::..|:..||:|..||.:..:
plant   389 LL-------------------------FYRGDSGAFDELQILKHKISLLEASNRELHNELQERRV 428

  Fly   429 DLTEKEMRAHIAEQAHDKLRSHVSELKN--KLDQREQAQFGNENTNGDNEMRDFSLLVNRVHVEL 491
            .......||:.|:...|||...:..::|  .||:.|..|  ||:..          |||:...::
plant   429 ASEHFSKRAYDAQVEKDKLIMIIESVRNGKSLDEIESCQ--NEDVG----------LVNKYVSKI 481

  Fly   492 QRTQEELESQGH-ESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYT---NKQMNFAGELR---- 548
            |..:.||.   | ::.::.|:..:::.....|...:.:|...|.|.:   :|.|:...||.
plant   482 QELEGELL---HIKNLKKTSNHQYSDDSYDVGPRSNNVLFPSSNESSDCEDKVMDVTDELEFQEK 543

  Fly   549 -----NINRQLDLK-QELHERI------MRNFSRLDSDDEDVKLRLCNQKIDDLEAERRDLMDQL 601
                 ::..:||:: :||.:|:      |:.||   |....|..:...:|:.|||.|:|.|..::
plant   544 EIEHCSLQEKLDMELKELDKRLEEKEAEMKRFS---SGGTSVLKQHYEKKVYDLEQEKRALQREI 605

  Fly   602 RNIKSK---------DISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLST 657
            ..::..         |.:.||.||..::|..||.::|.|::|...||.|::.:.|..:....|..
plant   606 EGLRHNLASIPSGPGDGAQKLKEEYVQKLNTLETQVSVLKKKQDAQAQLMRQKQKSDDAAIKLQD 670

  Fly   658 EIRTMKESKVKLIRAMRGESEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRK 722
            ||..:|..||:|.:.::.|||:||.||..||||:.|||.:.|:.:.|:.:...|:.||:.||:||
plant   671 EIHRIKSQKVQLQQKIKQESEQFRAWKASREKEVMQLKKEGRRNEYEMHKLMALNQKQKLVLQRK 735

  Fly   723 CEEALAANKRLKDALE-RQASAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDA-E 785
            .|||....||||:.|: |:||::...     :|.:..|:.                  :|:.| |
plant   736 TEEASQVTKRLKELLDNRKASSRETL-----SGANGPGTQ------------------ALMQAIE 777

  Fly   786 HSLEQLMEDRAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELE-MRNAQISDLQQKVCPTDL 849
            |.:|        :....|.::.|......|.|..|:.:|.|.||.| ::||:||.....:.|...
plant   778 HEIE--------VTVRVHEVRSEYERQTEERARMAKEVARLREENELLKNAKISVHGDTMSPGAR 834

  Fly   850 DSRIRSLAEGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQLLDAQQQE----- 909
            :|||.:|                       :..|..||     :||..:.:||.:|:::|
plant   835 NSRIFAL-----------------------ENMLATSS-----STLVSMASQLSEAEERERVFGG 871

  Fly   910 -----------DAASKRLRLLQSQHEEQMLAQQRAYE--EKVSVLIRTANQRWAEARSPAE--DQ 959
                       ||.|....|.......:.||:.:..:  || .||||...::..:..|...  :.
plant   872 RGRWNQVRTLGDAKSIMNYLFNLASTARCLARDKEADCREK-DVLIRDLKEKIVKFSSYVRYMEI 935

  Fly   960 QRNQILEELLSSREALQQELDKLRAKNKSKSKAVKSEPQDLDDSFQIVDGNETVVLSDVS----- 1019
            |:..::.::.:...|:::.......||:...|  |.|.:           |.|:||.|:.
plant   936 QKADLVHQVKAQTSAMKKLSADENLKNEHSMK--KQETR-----------NSTIVLEDMDTSDSE 987

  Fly  1020 ------DDPD----WVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSSIQ----SLNSTSATE 1070
                  :|||    |.|. .:|:| :|:..:||....|::..|....:|.:.    ..||.:.::
plant   988 ASDHEREDPDLDDEWKPE-HESER-ESEQESVIKLNRKRNFKVGRRRSSVVMRRSYEENSETPSD 1050

  Fly  1071 DGKR----CKGCKCRTKCTTKRCGCLSGNNACSETCVCKS-NCRNPLNL---------KDHASQC 1121
            |..:    |..|...:.|.|.:|.|.:...:|..:|.|.| .|.| .|.         :..|.:.
plant  1051 DAVKSDVCCCTCSKSSSCKTMKCQCRATKGSCGPSCGCSSVKCSN-RNADGKENNSISESEALEN 1114

  Fly  1122 GDGDGQKDETED-------------------ADK----SDDDG---------DDEPQTSKENAVK 1154
            |:...:.||.:.                   |||    ::|||         .|...|:.:|::|
plant  1115 GENSQESDEKDKGQQQQVLASRGAMLLQNALADKPEEETNDDGGTRRRRKPLSDIGNTTVKNSLK 1179

  Fly  1155 F 1155
            |
plant  1180 F 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	159/358 (44%)
		Kinesin	14..335	CDD:278646	155/350 (44%)
		Smc	<396..>994	CDD:224117	165/651 (25%)
		FlaC	522..633	CDD:225888	35/138 (25%)
		TCR	1075..1110	CDD:281618	11/35 (31%)
AT5G60930	NP_001332385.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1060
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69022
Inparanoid	1	1.050	449	1.000	Inparanoid score	I388
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	1	1.000	-	-		FOG0003140
OrthoInspector	1	1.000	-	-		otm3559
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	1	1.100	-	-	O	PTHR47969
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.870