DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp3A and FRA1

DIOPT Version :9

Sequence 1:	NP_001284830.1	Gene:	Klp3A / 31240	FlyBaseID:	FBgn0011606	Length:	1212	Species:	Drosophila melanogaster
Sequence 2:	NP_199593.2	Gene:	FRA1 / 834833	AraportID:	AT5G47820	Length:	1035	Species:	Arabidopsis thaliana

Alignment Length:	998	Identity:	320/998 - (32%)
Similarity:	505/998 - (50%)	Gaps:	169/998 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DPSCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDS-QKDLFETC 68
            |...|.||:.:|||:..|..:||:..| ....|.|||.:. :.|:|:::|:....| ..:::|.|
plant     8 DDCSVKVAVHIRPLIGDERIQGCQDCV-TVVTGKPQVQIG-SHSFTFDHVYGSSGSPSTEMYEEC 70

  Fly    69 VQAKVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHVGVIPRAVHDIFTAIAEMQSEFRF 133
            ....|..|..|||.|:||||||||||||||||....  ....|:||:.::.:||.|..::.:..|
plant    71 AAPLVDGLFQGYNATVLAYGQTGSGKTYTMGTGCGD--SSQTGIIPQVMNALFTKIETLKQQIEF 133

  Fly   134 AVTCSFVELYQEQFYDLFSSKTRDKA------------------TVDIREVKNRII-MPGLTELV 179
            .:..||:|:::|:..||....|.:|:                  .:.|||..|.:| :.|.||:.
plant   134 QIHVSFIEIHKEEVQDLLDPCTVNKSDTNNTGHVGKVAHVPGKPPIQIRETSNGVITLAGSTEVS 198

  Fly   180 VTSAQQVTDHLIRGSAGRAVAATAMNETSSRSHAIFTLTLVATK-----------LDG--KQSVT 231
            |::.:::...|.:||..||..:|.||..|||||||||:|:...:           .:|  |:...
plant   199 VSTLKEMAACLDQGSVSRATGSTNMNNQSSRSHAIFTITVEQMRKINTDSPENGAYNGSLKEEYL 263

  Fly   232 TSRFNLVDLAGSERCSKTLASGDRFKEGVNINKGLLALGNVINALGSGQA---AGYIPYRQSKLT 293
            .::.:|||||||||..:|.:.|.||||||:||||||||||||:|||..:.   ..::|||.||||
plant   264 CAKLHLVDLAGSERAKRTGSDGLRFKEGVHINKGLLALGNVISALGDEKKRKDGAHVPYRDSKLT 328

  Fly   294 RLLQDSLGGNSITLMIACVSPADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQ 358
            |||||||||||.|:||||:||||.|..|||:||:||:||..|:||||||.||.::|:..::..::
plant   329 RLLQDSLGGNSRTVMIACISPADINAEETLNTLKYANRARNIRNKPVVNRDPVSSEMLKMRQQVE 393

  Fly   359 KLRVELLSGGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTLQDRNRKLQQEL 423
            .|:.||                          ||....::.||:|.|||::..|:..|.:|.:||
plant   394 YLQAEL--------------------------SLRTGGSSCAEVQALKERIVWLETANEELCREL 432

  Fly   424 HQSLLDLTEKEMRAHIAEQAHDKLRSHVSELKNKLDQREQAQFGNENTNGDNEMRDFSLLVNRVH 488
            |         |.|:......|.:        |:..|.|.....|:...:|
plant   433 H---------EYRSRCPGVEHSE--------KDFKDIRADDIVGSVRPDG--------------- 465

  Fly   489 VELQRTQEELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQMNFAGELRNINRQ 553
              |:|:...:||..:...:..:..|. |..|...:..|::|.:..::          ||..:||:
plant   466 --LKRSLHSIESSNYPMVEATTGDSR-EIDEEAKEWEHKLLQNSMDK----------ELYELNRR 517

  Fly   554 LDLKQELHERIMRNFSRLDSDDEDVKLRLCNQKIDDLEAERRD-------LMDQLRNIKSKDISA 611
            |:.|    |..|:.|   |..|.....:...:||.::|.|:|.       |:.::.|:.|...:.
plant   518 LEEK----ESEMKLF---DGYDPAALKQHFGKKIAEVEDEKRSVQEERNRLLAEIENLASDGQAQ 575

  Fly   612 KLAEERRKRLQLLEQEISDLRRKLITQANLLKIRDKEREKIQNLSTEIRTMKESKVKLIRAMRGE 676
            ||.:...:.|:.||.:|.||::|..:|..|||.:.|..:..:.|..||:::|..||:|...|:.|
plant   576 KLQDVHAQNLKALEAQILDLKKKQESQVQLLKQKQKSDDAARRLQDEIQSIKAQKVQLQHRMKQE 640

  Fly   677 SEKFRQWKMVREKELTQLKSKDRKMQSEIVRQQTLHSKQRQVLKRKCEEALAANKRLKDALERQA 741
            :|:|||||..|||||.||:.:.||.:.|..:.|.|:.:|:.||:||.|||..|.||||:.||.:.
plant   641 AEQFRQWKASREKELLQLRKEGRKSEYERHKLQALNQRQKMVLQRKTEEAAMATKRLKELLEARK 705

  Fly   742 SAQAQRHKYKDNGGSAAGSSNANAKTDSWVDRELEIILSLIDAEHSLEQLMEDRAVINNHYHLLQ 806
            |: .:.|....||....|.:|..: ...|:|.|||:::::.:..|..|:....||.:.....:|:
plant   706 SS-PREHSAGTNGFGTNGQTNEKS-LQRWLDHELEVMVNVHEVRHEYEKQSHVRAALAEELAVLR 768

  Fly   807 Q------------------EKTSDPAEAAEQARILASLEEELEMRNAQISDLQQKVCPTDLDSRI 853
            |                  .:.|..:..|..||| :|||..|.:.:..:..:..::  ::.:.|.
plant   769 QVDEFAVKGLSPPRGKNGFARASSLSPNARMARI-SSLENMLVISSNSLVAMASQL--SEAEERE 830

  Fly   854 RSLA-----EGVQSLGESRTVSKQLLKTLVQQRRLQASSLNEQRTTLDELRAQ-------LLDAQ 906
            |:..     ..::|:||::.:.:.:..:|.:.|    ..|.|:...:.|::.|       |..::
plant   831 RAFTNRGRWNQLRSMGEAKNLLQYMFNSLAETR----CQLWEKDVEIKEMKDQFKEIVGLLRQSE 891

  Fly   907 QQEDAASKRLRLLQSQHEEQMLA 929
            .:...|.|.|:|     .||.:|
plant   892 LRRKEAEKELKL-----REQAIA 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_001284830.1	KISc_KIF4	7..336	CDD:276823	155/364 (43%)
		Kinesin	14..335	CDD:278646	152/356 (43%)
		Smc	<396..>994	CDD:224117	149/571 (26%)
		FlaC	522..633	CDD:225888	29/117 (25%)
		TCR	1075..1110	CDD:281618
FRA1	NP_199593.2	KISc_KIF4	10..371	CDD:276823	155/364 (43%)
FRA1	NP_199593.2	SbcC	<490..>912	CDD:223496	124/451 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0244
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	449	1.000	Inparanoid score	I388
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D369179at2759
OrthoFinder	1	1.000	-	-		FOG0003140
OrthoInspector	1	1.000	-	-		otm3559
orthoMCL	1	0.900	-	-		OOG6_100464
Panther	1	1.100	-	-	LDO	PTHR47969
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2108
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.870