Protein Alignment Klp3A and KINESIN-12B

DIOPT Version :10

• Sequence 1: NP_525053.1
• Gene: Klp3A / 31240
• FlyBaseID: FBgn0011606
• Length: 1212
• Species: Drosophila melanogaster
• Sequence 2: NP_189009.2
• Gene: KINESIN-12B / 821947
• AraportID: AT3G23670
• Length: 1313
• Species: Arabidopsis thaliana
• Alignment Length: 1291
• Identity: 314/1291 - (24%)
• Similarity: 524/1291 - (40%)
• Gaps: 320/1291 - (24%)

  Fly     7 SCVAVALRVRPLVQSELDRGCRIAVERSADGAPQVTVNRNESYTYNYVFDIDDSQKDLFETCVQA 71
            |.|.|.:|::|..:.|.:   .:.|::.::.|  :|:| .:::|::.:.|.:.:|.::|:.....
plant    95 SGVKVIVRMKPPSKGEEE---EMIVKKISNDA--LTIN-EQTFTFDSIADPESTQDEIFQLVGAP 153

  Fly    72 KVKKLLNGYNVTILAYGQTGSGKTYTMGTAFNGVLDDHV-----GVIPRAVHDIFTAIAEMQS-- 129
            .|:..|.|:|.::.|||||||||||||....||:|::|:     |:.||....:|..::|.|:
plant   154 LVENCLAGFNSSVFAYGQTGSGKTYTMWGPANGLLEEHLSGDQRGLTPRVFELLFARLSEEQAKH 218

  Fly   130 ---EFRFAVTCSFVELYQEQFYDLFSSKTRDKATVDIRE-VKNRIIMPGLTELVVTSAQQVTDHL 190
               :.::...|||:|:|.||..||.....::   :.||| ||:.:.:..|||..|.:.:.::..|
plant   219 AERQLKYQCRCSFLEIYNEQITDLLDPSLKN---LMIREDVKSGVYVENLTEEYVKNLKDLSKLL 280

  Fly   191 IRGSAGRAVAATAMNETSSRSHAIFTLTLVA---TKLDGKQSVTTSRFNLVDLAGSERCSKTLAS 252
            ::|.|.|...||::|..|||||.:||..:.:   :..||..|..|||.||||||||||...|.|:
plant   281 VKGLANRRTGATSVNAESSRSHCVFTCVVESHCKSVADGLSSFKTSRINLVDLAGSERQKLTGAA 345

  Fly   253 GDRFKEGVNINKGLLALGNVINALGSGQAAG---YIPYRQSKLTRLLQDSLGGNSITLMIACVSP 314
            |||.||..|||:.|..|||:||.|......|   :||||.|:||.|||:|||||:...|:..|||
plant   346 GDRLKEAGNINRSLSQLGNLINILAEISQTGKQRHIPYRDSRLTFLLQESLGGNAKLAMVCAVSP 410

  Fly   315 ADYNVAETLSTLRYADRALQIKNKPVVNLDPHAAEVNMLKDVIQKLRVELLS------------- 366
            :....:||.||||:|.||..|:||.:|| :....:||.|::||::||.||..
plant   411 SQSCRSETFSTLRFAQRAKAIQNKAIVN-EVMQDDVNFLREVIRQLRDELQRVKDDKGNNPTNPN 474

  Fly   367 -------GGKMSSSLISAVGAAGLGAIPCEESLAGSMANAAEIQRLKEQVRTL----------QD 414
                   ..:.|.||:.:.|.....::|     .|......|::..:|.|..|          :|
plant   475 AAYTTSWNARRSLSLLRSFGLGHPKSLP-----NGDDDGDTEMEIDEEAVERLCAQMGLSPPAED 534

  Fly   415 RNRKLQ--QELHQSLLDLTEKE---MRAHI---------AEQAHDKLRSHVSELKNKLDQREQAQ 465
            .|:::.  ::::.||..:..|:   ..:|:         .|.|..:..::.||..|.|...|...
plant   535 NNQEMSRVEKINSSLQTVVLKDESYNNSHLKSSEATDVNMEDACCQTENNGSETDNALTVAETMD 599

  Fly   466 FGN---------------ENTNGDNE---------------MRDFSLLVNRVHVELQRTQ----- 495
            .|:               .:||..|.               ..|.|.:|:.........|
plant   600 DGSSVQPDSITNSLHSCISDTNQGNSPSKAENIPSCQDLVIEADVSAIVSVADTSNNTEQVSVNP 664

  Fly   496 --------------------EELESQGHESRQRLSSRSHTEGGESGGDEVHEMLHSHSEEYTNKQ 540
                                |....:...||:.|.:.|.:...:...:..:::    :.|.....
plant   665 VSPCLSVAPVSVSPVLIPPTESASPKIRNSRKSLRTTSMSTASQKDIERANQL----TPEVVEPS 725

  Fly   541 MNFAGELRNINRQLDLK---------QELHERIMRNFSRLDSDDEDVKLRLCNQKID-------- 588
            ...:.|:.|:...|..|         ::|...:.|....|||..:...||....::.
plant   726 PAMSTEVLNLYSALSTKKSEAFPVPTRQLAASLHRGMKLLDSYRQSTALRRSTFRLSYKALECKP 790

  Fly   589 -------DLEAERRDLMDQLRNIKSKDISAKLAEERRKRLQLLEQEISDLRRKLITQANLLKIRD 646
                   |:..:.....|::....||::   |....:.|.:...|||||     .:...|:.|.:
plant   791 STVLSKADVGVQTYPQADEIAEDNSKEV---LCSRCKCRAECDAQEISD-----TSNLQLVPIDN 847

  Fly   647 KEREKIQN----------LSTEIR---------TMKESKV----KLIRAMRGESE------KFRQ 682
            .|..:..|          |:..||         |.:.|::    :|::..:.|.|      :.|:
plant   848 SEGSEKSNFQVPKAVEKVLAGSIRREMAMEEFCTKQASEISQLNRLVQQYKHERECNAIIGQTRE 912

  Fly   683 WKMVR-EKELTQLKSKDRKMQSEIVRQQTLHS-------------KQRQVLKRKCEEALAANKRL 733
            .|:|| |..:..:.|||..:..|.......|.             :.|..|||..||..:.....
plant   913 DKIVRLESLMDGVLSKDDFLDEEFASLMHEHKLLKDMYENHPEVLQTRIELKRVQEELESFKNFY 977

  Fly   734 KDALERQA------SAQAQRHKYKDNGGSAAGSSNANAKTDSWVD----RELEIILSLID--AEH 786
            .|..||:.      ..:||...|.|:..::|....:..|.....|    .:|..|...:|  .|.
plant   978 GDMGEREVLLEEIHDLKAQLQCYTDSSLTSARRRGSLLKLTYACDPNQAPQLNTIPESVDEGPEK 1042

  Fly   787 SLEQ--------------LMED-RAVINNHYHLLQQEKTSDPAEAAEQARILASLEEELEMRN-- 834
            :|||              |.|: |..::.:..|::::|    .|...:.|....|.|.::|..
plant  1043 TLEQERLRWTEAESNWISLAEELRTELDTNRLLMEKQK----RELDTEKRCAEELTEAMQMAMQG 1103

  Fly   835 -----AQISDLQQKVCPTDLDSRIRSLAEGVQSL-----------GESRTVSKQL--LKTLVQQR 881
                 .|.:||::|  ...|.:|.|.:.||:..:           .|||.::...  :..|..||
plant  1104 HARMIEQYADLEEK--HIQLLARHRRIREGIDDVKKAAARAGVKGAESRFINALAAEISALKVQR 1166

  Fly   882 RLQASSLNEQRTTLDELRAQLLDAQQQEDAASKRLRLLQSQHEEQMLAQQRAYEEKVSVLIRTAN 946
            ..:.....::..:   |::||.|..:...||.:.|...:...|....||:||.:         |.
plant  1167 EKEVRYFRDENKS---LQSQLRDTAEAVQAAGELLVRFKEAEEGLTFAQKRAMD---------AE 1219

  Fly   947 QRWAEARSPAEDQQRNQILEELLSSREALQQELDKLRAKNKSKSKAV----KSEPQDLDDSFQIV 1007
            ...:||                       .:::|||:.|.:::...|    .:|||:..:|.|..
plant  1220 YEASEA-----------------------YKKVDKLKRKYETEISTVNQQHNAEPQNPIESLQAS 1261

  Fly  1008 DGNETVVLSD---VSD-DPDWVPSTSKSKRIQSDSRNVISPPEKQDANVTSLGNSS 1059
            ..::.:...|   .|| |..|              |....|..|:|..::.|...|
plant  1262 CNDDAMAKYDEPSASDGDNQW--------------REEFQPFYKKDEELSKLAEPS 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp3A	NP_525053.1	KISc_KIF4	7..336	CDD:276823	135/345 (39%)
		Smc	<453..>985	CDD:440809	128/700 (18%)
		Metallothio	<1071..1115	CDD:395080
KINESIN-12B	NP_189009.2	PLN03188	1..1313	CDD:215621	314/1291 (24%)